US5214135A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,N-diisopropyl phosphoramidite ribonucleosides
Assignee: ChemGenes Corp
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Filing: 1991-08-30
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Granted: 1993-05-25
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Expires: 2011-08-30
Abstract
Abstract This invention is directed to N (amino)-protected-2'-O-methyl (methoxy)-5'-dimethoxytrityl (dimethoxytrityl) ribonucleosides (Group I compounds) and to N-protected-2'-O-methyl-5'-dimethoxytrityl-3'-ribonucleoside cyanoethyl N,N-diisopropyl phosphoramidites (Group II compounds). This invention is further directed to the processes involved in producing these compounds. The purification processes produce products in Group I with purity in excess of 99.50% and up to 99.8%. The purity of the products in Group II ranges in excess of 99.8% and up to 99.9%.
Inventors
- 👤 Suresh C. Srivastava
- 👤 Saroj K. Roy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 14:05
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H21/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
5 words
N 2 -isobutyryl-O 6 -methyl-2'-O-methyl-5'-dimethoxytritylguanosine.
Claim 2
Dependent Claim
5 words
N 2 -isobutyryl-O 6 -methyl-2'-O-methyl-5'-dimethoxytritylguanosine.
Claim 3
Dependent Claim
4 words
N 6 -benzoyl-2'-O-methyl-5'-dimethoxytrityl-adenosine-3'-cyanoethyl-N,N-diisopropyl phosphoramidite.
Claim 4
Dependent Claim
4 words
N 6 -benzoyl-2'-O-methyl-5'-dimethoxytrityl-adenosine-3'-cyanoethyl-N,N-diisopropyl phosphoramidite.
Claim 5
Dependent Claim
4 words
N 2 -isobutyryl-2'-O-methyl-5'-dimethoxytrityl-3'-guanosine-3'-cyanoethyl-N,N-diisopropyl phosphoramidite.
Claim 6
Dependent Claim
4 words
N 2 -isobutyryl-2'-O-methyl-5'-dimethoxytrityl-3'-guanosine-3'-cyanoethyl-N,N-diisopropyl phosphoramidite.
References Cited (Backward Citations)
US4500707A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-05-24 | 1996-11-23 | 1997-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-05-24 | 2000-11-23 | 2001-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-05-24 | 2004-11-23 | 2005-05-25 | $7700.00 | Window Closed / Lapsed |