US4500707A
Expired / Lapsed
US
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Nucleosides useful in the preparation of polynucleotides
Assignee: University Patents Inc
•
Filing: 1982-03-16
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Granted: 1985-02-19
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Expires: 2002-03-16
Abstract
Abstract New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).
Inventors
- 👤 Marvin H. Caruthers
- 👤 Mark D. Matteucci
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:33
CPC Classifications
C; C07; C07H; C07H21/00; B; B01; B01J; B01J19/00; B01J19/0046; C07H19/00; C07H19/02; C07H19/04; B01J2219/00; B01J2219/00274; B01J2219/00277; B01J2219/00279; B01J2219/00281; B01J2219/00286; B01J2219/00351; B01J2219/00389; B01J2219/00497; B01J2219/005; B01J2219/00583; B01J2219/0059; B01J2219/00596; B01J2219/0068; B01J2219/00686; B01J2219/00718; B01J2219/0072; B01J2219/00722; C40; C40B; C40B40/00; C40B40/04; C40B40/06; C40B60/00; C40B60/14; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/582
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
66 words
A compound of the formula: ##STR12## wherein B is a nucleoside or deoxynucleoside base; R is H or a blocking group, A is H or OR; R' is a hydrocarbyl radical containing up to 10 carbon atoms and X is a amino group formed by removal of the hydrogen atom from a ring nitrogen of a nitrogen heterocyclic compound which contains unsaturation in the ring structure.
Claim 2
Dependent Claim
66 words
A compound of the formula: ##STR12## wherein B is a nucleoside or deoxynucleoside base; R is H or a blocking group, A is H or OR; R' is a hydrocarbyl radical containing up to 10 carbon atoms and X is a amino group formed by removal of the hydrogen atom from a ring nitrogen of a nitrogen heterocyclic compound which contains unsaturation in the ring structure.
Claim 3
Dependent Claim
52 words
A compound of the formula: ##STR13## wherein B is a nucleoside or deoxynucleoside base; R is H or a blocking group; A is H or OR: R' is lower alkyl and X is a amino group formed by removal of the H atom of the amino nitrogen of a nitrogen heterocyclic compound.
Claim 4
Dependent Claim
52 words
A compound of the formula: ##STR13## wherein B is a nucleoside or deoxynucleoside base; R is H or a blocking group; A is H or OR: R' is lower alkyl and X is a amino group formed by removal of the H atom of the amino nitrogen of a nitrogen heterocyclic compound.
Claim 5
Dependent Claim
17 words
The compound according to claim 1 or 2 wherein the amino group is tetrazolyl, nitroimidazolyl or triazolyl.
Claim 6
Dependent Claim
17 words
The compound according to claim 1 or 2 wherein B is thymine, cytosine, adenosine, uracil and guanine.
Claim 7
Dependent Claim
14 words
The compound according to claim 1 or 2 wherein R is a trityl group.
Claim 8
Dependent Claim
14 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl or p-anisylphenylmethyl.
Claim 9
Dependent Claim
10 words
The compound according to claim 2 wherein A is H.
Claim 10
Dependent Claim
25 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl, B is 9-(N-6-benzoyladeninyl), R' is methyl, A is H and X is tetrazolyl.
Claim 11
Dependent Claim
25 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl, B is thyminyl, R' is methyl, A is H and X is tetrazolyl.
Claim 12
Dependent Claim
25 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl, B is 1-cytosinyl, R' is methyl, A is H and X is tetrazolyl.
Claim 13
Dependent Claim
25 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl, B is 9-(N-6-benzoyladeninyl), R' is methyl, A is H and X is tetrazolyl.
Claim 14
Dependent Claim
25 words
The compound according to claim 1 or 2 wherein R is di-p-anisylphenylmethyl, B is 9-guaninyl, R' is methyl, A is H and X is tetrazolyl.
Claim 15
Dependent Claim
13 words
The compound according to claim 10 wherein B is 1-(N-4-acetylcytosine), 1-(N-benzoylcytosine, or 1-(N-isobutyrylcytosine).
Claim 16
Dependent Claim
13 words
The compound according to claim 12 wherein B is 9-(N-6-benzoylguaninyl), 9-(N-6-acetylguaninyl), or 9-(N-6-isobutyrylguaninyl).
Claim 17
Dependent Claim
12 words
The compound according to claim 8 wherein B is 9-(N-6-acetyladeninyl) or 9-(N-6-isobutyryladeninyl).
Claim 18
Dependent Claim
12 words
The compound according to claim 11 wherein B is 9-(N-6-acetyladeninyl) or 9-(N-6-isobutyryladeninyl).
References Cited (Backward Citations)
US4373071A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-19 | 1988-08-20 | 1989-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-19 | 1992-08-20 | 1993-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-19 | 1996-08-20 | 1997-02-19 | $7700.00 | Window Closed / Lapsed |