Patent US5964804A successfully refreshed from Google Patents.
US5964804A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Close vascularization implant material
Assignee: Baxalta GmbH
•
Filing: 1995-06-07
•
Granted: 1999-10-12
•
Expires: 2015-06-07
Abstract
Abstract A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.
Inventors
- 👤 James H. Brauker
- 👤 Robert C. Johnson
- 👤 Laura A. Martinson
- 👤 Ronald S. Hill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:46
CPC Classifications
A; A61; A61F; A61F2/00; A61L; A61L29/00; A61L29/08; A61L29/085; A61F2/02; A61F2/022; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/50; A61L27/56; A61L29/005; A61L29/14; A61L29/146; A61B; A61B5/00; A61B5/145; A61B5/14532; A61B5/41; A61B5/413; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/924; Y10S623/925
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
168 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a first zone of a first porous material proximate the chamber wherein the first porous material is permeable to the flow of nutrients from the host to living cells and products from the living cells to host and impermeable to host immune cells and maintains immunoisolation of the chamber; and (b) a second zone of a second porous material outside of the first zone comprising the porous structure as shown in FIG. 4(a) or 4(b), wherein the second porous material comprises frame of elongated strands of material that are less than 5 mm in all but the longest dimension, said frames define apertures which interconnect to form a three dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology and which promote host vascularization adjacent to but not substantially into the second zone upon implantation into a host.
Claim 2
Independent Claim
168 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a first zone of a first porous material proximate the chamber wherein the first porous material is permeable to the flow of nutrients from the host to living cells and products from the living cells to host and impermeable to host immune cells and maintains immunoisolation of the chamber; and (b) a second zone of a second porous material outside of the first zone comprising the porous structure as shown in FIG. 4(a) or 4(b), wherein the second porous material comprises frame of elongated strands of material that are less than 5 mm in all but the longest dimension, said frames define apertures which interconnect to form a three dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology and which promote host vascularization adjacent to but not substantially into the second zone upon implantation into a host.
Claim 3
Dependent Claim
22 words
The device of claim 1, wherein the second porous material has a nominal pore size ranging from about 0.6 to 20 μm.
Claim 4
Dependent Claim
16 words
The device of claim 1, wherein the first porous material is impermeable to host immune factors.
Claim 5
Dependent Claim
57 words
The device of claim 1, wherein the second porous material is selected from the group consisting of mixed esters cellulose having a nominal pore size ranging from 1.2 to 8.0 μm; cellulose acetate having a nominal pore size ranging from 0.8 to 8.0 μm; and PTFE/polyester having a nominal pore size ranging from 1.0 to 15 μm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-10-11 | 2003-04-12 | 2003-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-10-11 | 2007-04-12 | 2007-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-10-11 | 2011-04-12 | 2011-10-12 | $7700.00 | Window Closed / Lapsed |