US5964804A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Close vascularization implant material
Assignee: Baxalta GmbH
•
Filing: 1995-06-07
•
Granted: 1999-10-12
•
Expires: 2015-06-07
Abstract
Abstract A device for implantation in a host having a material at an interface between the host and the device, said material having a conformation which results in growth of vascular structures by the host close to the interface.
Inventors
- 👤 James H. Brauker
- 👤 Robert C. Johnson
- 👤 Laura A. Martinson
- 👤 Ronald S. Hill
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:46
CPC Classifications
A; A61; A61F; A61F2/00; A61L; A61L29/00; A61L29/08; A61L29/085; A61F2/02; A61F2/022; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/50; A61L27/56; A61L29/005; A61L29/14; A61L29/146; A61B; A61B5/00; A61B5/145; A61B5/14532; A61B5/41; A61B5/413; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/924; Y10S623/925
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
168 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a first zone of a first porous material proximate the chamber wherein the first porous material is permeable to the flow of nutrients from the host to living cells and products from the living cells to host and impermeable to host immune cells and maintains immunoisolation of the chamber; and (b) a second zone of a second porous material outside of the first zone comprising the porous structure as shown in FIG. 4(a) or 4(b), wherein the second porous material comprises frame of elongated strands of material that are less than 5 mm in all but the longest dimension, said frames define apertures which interconnect to form a three dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology and which promote host vascularization adjacent to but not substantially into the second zone upon implantation into a host.
Claim 2
Independent Claim
168 words
A device having a wall defining a chamber for holding living cells for implanting into a mammalian host wherein the wall comprises: (a) a first zone of a first porous material proximate the chamber wherein the first porous material is permeable to the flow of nutrients from the host to living cells and products from the living cells to host and impermeable to host immune cells and maintains immunoisolation of the chamber; and (b) a second zone of a second porous material outside of the first zone comprising the porous structure as shown in FIG. 4(a) or 4(b), wherein the second porous material comprises frame of elongated strands of material that are less than 5 mm in all but the longest dimension, said frames define apertures which interconnect to form a three dimensional cavities which permit substantially all inflammatory cells migrating into the cavities to maintain a rounded morphology and which promote host vascularization adjacent to but not substantially into the second zone upon implantation into a host.
Claim 3
Dependent Claim
22 words
The device of claim 1, wherein the second porous material has a nominal pore size ranging from about 0.6 to 20 μm.
Claim 4
Dependent Claim
16 words
The device of claim 1, wherein the first porous material is impermeable to host immune factors.
Claim 5
Dependent Claim
57 words
The device of claim 1, wherein the second porous material is selected from the group consisting of mixed esters cellulose having a nominal pore size ranging from 1.2 to 8.0 μm; cellulose acetate having a nominal pore size ranging from 0.8 to 8.0 μm; and PTFE/polyester having a nominal pore size ranging from 1.0 to 15 μm.
References Cited (Backward Citations)
US3093831A
Cited
US3313289A
Cited
US3967618A
Cited
US3646616A
Cited
US3699956A
Cited
US4069307A
Cited
US4011861A
Cited
US3993072A
Cited
US4374669A
Cited
US4936317A
Cited
US4180560A
Cited
US4229838A
Cited
US4192308A
Cited
US4306318A
Cited
US4321711A
Cited
US4207390A
Cited
US4217664A
Cited
US4391909A
Cited
US4352883A
Cited
US4266999A
Cited
US4298002A
Cited
US4309996A
Cited
US4309776A
Cited
US4368737A
Cited
US4576608A
Cited
US4353888A
Cited
GB2095257A
Cited
US4557724A
Cited
US4553272A
Cited
US4413359A
Cited
US4378016A
Cited
US4542539A
Cited
US4475916A
Cited
US4505277A
Cited
US4664669A
Cited
US4673566A
Cited
EP0127989A2
Cited
CA1196862A
Cited
US4689293A
Cited
US4806355A
Cited
US4803168A
Cited
US4670286A
Cited
US4601893A
Cited
US4508113A
Cited
US4684524A
Cited
US4657544A
Cited
US4686098A
Cited
US4681582A
Cited
US4687481A
Cited
US4597765A
Cited
EP0188309A2
Cited
US4685447A
Cited
US4624847A
Cited
US4712553A
Cited
EP0216149A2
Cited
EP0213908A2
Cited
EP0232543A2
Cited
US4822361A
Cited
US4743252A
Cited
GB2185408B
Cited
US4723947A
Cited
US4871366A
Cited
US4804381A
Cited
US4798585A
Cited
EP0259536A2
Cited
US4880006A
Cited
US4868098A
Cited
EP0277678A1
Cited
US5047050A
Cited
US4877029A
Cited
US4816339A
Cited
US4826480A
Cited
US4871542A
Cited
US4795459A
Cited
US4911717A
Cited
US4878913A
Cited
US5077215A
Cited
US4922926A
Cited
US4892538A
Cited
US5182111A
Cited
US4855141A
Cited
US4950483A
Cited
US5011472A
Cited
US5219361A
Cited
EP0359575A2
Cited
US4878895A
Cited
DE8813531U1
Cited
EP0370292A1
Cited
US5017490A
Cited
US4990138A
Cited
US5015476A
Cited
US4937196A
Cited
US5002661A
Cited
US5112614A
Cited
US5024670A
Cited
US5100392A
Cited
US5324518A
Cited
US5156623A
Cited
US5201728A
Cited
US5213574A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-10-11 | 2003-04-12 | 2003-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-10-11 | 2007-04-12 | 2007-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-10-11 | 2011-04-12 | 2011-10-12 | $7700.00 | Window Closed / Lapsed |