US5902338A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anterior cruciate ligament heterograft
Assignee: Aperion Biologics Inc
•
Filing: 1995-09-15
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Granted: 1999-05-11
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Expires: 2015-09-15
Abstract
Abstract The invention provides an article of manufacture comprising a substantially non-immunogenic ligament or tendon heterografts for implantation into humans. The invention further provides a method for preparing an ligament heterograft by removing at least a portion of an ligament from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic ligament.
Inventors
- 👤 Kevin R. Stone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:41
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3691; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/3654; A61L27/3662; A61L27/3687; A61F; A61F2/00; A61F2/02; A61F2/08; A61L2430/00; A61L2430/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
89 words
A method of preparing a ligament heterograft for implantation into a human, which comprises a. removing at least a portion of a ligament from a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. piercing the heterograft; d. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling; whereby the heterograft has substantially the same mechanical properties as the ligament; and e. treating the heterograft with an enzyme.
Claim 2
Independent Claim
89 words
A method of preparing a ligament heterograft for implantation into a human, which comprises a. removing at least a portion of a ligament from a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. piercing the heterograft; d. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling; whereby the heterograft has substantially the same mechanical properties as the ligament; and e. treating the heterograft with an enzyme.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said enzyme is selected from the group consisting of ficin, trypsin, and a glycosidase.
Claim 4
Dependent Claim
35 words
The method of claim 1, comprising the further step following step c of treating the heterograft with one or more agents selected from the group consisting of anticalcification agents, antithrombotic agents, antibiotics, and growth factors.
Claim 5
Dependent Claim
16 words
The method of claim 1, comprising the further step following step c of sterilizing the heterograft.
Claim 6
Dependent Claim
31 words
The method of claim 4, wherein said sterilizing step is selected from the group consisting of treatment with glutaraldehyde, treatment with formaldehyde, treatment with ethylene oxide, and treatment with propylene oxide.
Claim 7
Independent Claim
90 words
A method of preparing a ligament heterograft for implantation into a human, which comprises a. removing at least a portion of a ligament from a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling; whereby the heterograft has substantially the same mechanical properties as the ligament; and d. treating the heterograft with an enzyme to remove surface carbohydrate moieties.
Claim 8
Independent Claim
90 words
A method of preparing a ligament heterograft for implantation into a human, which comprises a. removing at least a portion of a ligament from a non-human animal to provide a heterograft; b. washing the heterograft in water and alcohol; c. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling; whereby the heterograft has substantially the same mechanical properties as the ligament; and d. treating the heterograft with an enzyme to remove surface carbohydrate moieties.
Claim 9
Dependent Claim
13 words
A method according to claim 6 wherein said enzyme further comprises a glycosidase.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-05-10 | 2002-11-09 | 2003-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-05-10 | 2006-11-09 | 2007-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-05-10 | 2010-11-09 | 2011-05-11 | $7700.00 | Window Closed / Lapsed |