Patent US5849035A successfully refreshed from Google Patents.
US5849035A
Expired / Lapsed
US
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Methods for intraluminal photothermoforming
Assignee: Genzyme Corp
•
Filing: 1994-04-28
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Granted: 1998-12-15
•
Expires: 2014-04-28
Abstract
Abstract PCT No. PCT/US94/04824 Sec. 371 Date Oct. 30, 1995 Sec. 102(e) Date Oct. 30, 1995 PCT Filed Apr. 28, 1994 PCT Pub. No. WO94/24962 PCT Pub. Date Nov. 10, 1994A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
Inventors
- 👤 Chandrashekhar P. Pathak
- 👤 Amarpreet S. Sawhney
- 👤 Jeffrey A. Hubbell
- 👤 Stephen J. Herman
- 👤 Laurence A. Roth
- 👤 Patrick K. Campbell
- 👤 Kevin M. Berrigan
- 👤 Peter K. Jarrett
- 👤 Arthur J. Coury
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:42
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/94; A61F2/945; A61F2/95; A61L; A61L31/00; A61L31/14; B; B29; B29C; B29C35/00; B29C35/02; B29C35/08; B29C55/00; B29C55/22; B29C55/24; B29C70/00; B29C70/68; B29C70/74; A61B; A61B17/00; A61B17/22; A61B2017/22001; A61F2210/00; A61F2210/0014; A61F2210/0023; A61F2210/0047; A61F2220/00; A61F2220/0008; A61F2250/00; A61F2250/0058; A61F2250/0096; A61F2250/0098; B29C35/0805; B29C2035/0822; B29C2035/0827; B29C2035/0833; B29K; B29K2995/00; B29K2995/0037; B29K2995/0059; B29K2995/006; B29L; B29L2023/00; B29L2031/00; B29L2031/753; B29L2031/7542; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 73
Claim 1
Independent Claim
119 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to render the article softened; and reconfiguring the softened article, then applying the reconfigured, softened article to the tissue surface and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 2
Independent Claim
119 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to render the article softened; and reconfiguring the softened article, then applying the reconfigured, softened article to the tissue surface and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 3
Dependent Claim
14 words
A method as in claim 1, further comprising allowing the polymeric article to harden.
Claim 4
Dependent Claim
21 words
A method as in claim 1, wherein the tissue surface comprises an interior surface of a tissue lumen or hollow organ.
Claim 5
Dependent Claim
17 words
A method as in claim 3, wherein the tissue surface is a surface of a blood vessel.
Claim 6
Dependent Claim
29 words
A method as in claim 1, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 7
Dependent Claim
14 words
A method as in claim 1, wherein the chromophore comprises a dye or pigment.
Claim 8
Dependent Claim
12 words
A method as in claim 1, wherein the polymeric article is biodegradable.
Claim 9
Dependent Claim
30 words
A method as in claim 1, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 10
Dependent Claim
18 words
A method as in claim 8, wherein the radially expandable portion of the catheter comprises a dilatation balloon.
Claim 11
Dependent Claim
14 words
A method as in claim 1, wherein the polymeric article contains a therapeutic agent.
Claim 12
Dependent Claim
14 words
A method as in claim 1, wherein the polymeric article comprises a multi-layer structure.
Claim 13
Dependent Claim
14 words
A method as in claim 1, wherein the polymeric article contains a biocompatible coating.
Claim 14
Dependent Claim
53 words
A method as in claim 1, further comprising: positioning the polymeric article on an article-forming element positioned at a distal region of a tubular shaft of a catheter, the distal region constructed and arranged for insertion into a patient, the shaft also including a proximal region adapted to remain outside of the patient.
Claim 15
Dependent Claim
18 words
A method as in claim 13, wherein the molding step is carried out by expanding the article-forming element.
Claim 16
Dependent Claim
15 words
A method as in claim 14, wherein the article-forming element is a radially-expandable dilatation balloon.
Claim 17
Dependent Claim
40 words
A method as in claim 13, wherein the step of exposing the polymeric article to electromagnetic radiation comprises activating a source of electromagnetic radiation connected, via an optical fiber, to an emitter located at the distal region of the shaft.
Claim 18
Dependent Claim
36 words
A method as in claim 1, wherein the exposing step comprises exposing the polymeric article to the electromagnetic radiation for a period of time sufficient to soften a surface of the article facing the tissue surface.
Claim 19
Dependent Claim
26 words
A method as in claim 1, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 20
Independent Claim
119 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore and that is of a wavelength range that is not readily absorbed by the tissue surface for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 21
Independent Claim
119 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore and that is of a wavelength range that is not readily absorbed by the tissue surface for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 22
Dependent Claim
26 words
A method as in claim 19, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 23
Dependent Claim
29 words
A method as in claim 19, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 24
Dependent Claim
12 words
A method as in claim 19, wherein the polymeric article is biodegradable.
Claim 25
Dependent Claim
30 words
A method as in claim 19, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 26
Dependent Claim
14 words
A method as in claim 19, wherein the polymeric article contains a therapeutic agent.
Claim 27
Independent Claim
122 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article comprising a copolymer of at least two moieties selected from the group consisting of caprolactones, anhydrides, lactides, and glycolides that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 28
Independent Claim
122 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article comprising a copolymer of at least two moieties selected from the group consisting of caprolactones, anhydrides, lactides, and glycolides that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 29
Dependent Claim
26 words
A method as in claim 25, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 30
Dependent Claim
30 words
A method as in claim 25, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 31
Dependent Claim
14 words
A method as in claim 25, wherein the polymeric article contains a therapeutic agent.
Claim 32
Independent Claim
122 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore that is a dye or pigment selected from the group consisting of indocyanine, eosin, copper phthalocyanine, and combinations thereof, having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 33
Independent Claim
122 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore that is a dye or pigment selected from the group consisting of indocyanine, eosin, copper phthalocyanine, and combinations thereof, having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 34
Dependent Claim
26 words
A method as in claim 29, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 35
Dependent Claim
29 words
A method as in claim 29, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 36
Dependent Claim
12 words
A method as in claim 29, wherein the polymeric article is biodegradable.
Claim 37
Dependent Claim
30 words
A method as in claim 29, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 38
Dependent Claim
14 words
A method as in claim 29, wherein the polymeric article contains a therapeutic agent.
Claim 39
Independent Claim
111 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the entire article to the point that it becomes fluent; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 40
Independent Claim
111 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the entire article to the point that it becomes fluent; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 41
Dependent Claim
26 words
A method as in claim 35, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 42
Dependent Claim
29 words
A method as in claim 35, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 43
Dependent Claim
12 words
A method as in claim 35, wherein the polymeric article is biodegradable.
Claim 44
Dependent Claim
30 words
A method as in claim 35, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 45
Dependent Claim
14 words
A method as in claim 35, wherein the polymeric article contains a therapeutic agent.
Claim 46
Independent Claim
118 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the entire article to the point that it becomes fluent; determining when the polymeric article becomes fluent; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 47
Independent Claim
118 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the entire article to the point that it becomes fluent; determining when the polymeric article becomes fluent; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 48
Dependent Claim
26 words
A method as in claim 41, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 49
Dependent Claim
29 words
A method as in claim 41, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 50
Dependent Claim
12 words
A method as in claim 41, wherein the polymeric article is biodegradable.
Claim 51
Dependent Claim
30 words
A method as in claim 41, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 52
Dependent Claim
14 words
A method as in claim 41, wherein the polymeric article contains a therapeutic agent.
Claim 53
Independent Claim
148 words
A method for providing a polymeric article on a tissue surface, comprising: positioning a polymeric article, which contains a chromophore having an absorption characteristic, surrounding an article-forming element proximate to a tissue surface at a distal region of a tubular shaft of a catheter, the distal region constructed and arranged for insertion into a patient, the shaft also including a proximal region adapted to remain outside of the patient; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface by expanding the article-forming element, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 54
Independent Claim
148 words
A method for providing a polymeric article on a tissue surface, comprising: positioning a polymeric article, which contains a chromophore having an absorption characteristic, surrounding an article-forming element proximate to a tissue surface at a distal region of a tubular shaft of a catheter, the distal region constructed and arranged for insertion into a patient, the shaft also including a proximal region adapted to remain outside of the patient; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface by expanding the article-forming element, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 55
Dependent Claim
26 words
A method as in claim 47, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 56
Dependent Claim
29 words
A method as in claim 47, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 57
Dependent Claim
12 words
A method as in claim 47, wherein the polymeric article is biodegradable.
Claim 58
Dependent Claim
14 words
A method as in claim 47, wherein the polymeric article contains a therapeutic agent.
Claim 59
Independent Claim
104 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a thermochromic chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 60
Independent Claim
104 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a thermochromic chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 61
Dependent Claim
26 words
A method as in claim 52, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 62
Dependent Claim
29 words
A method as in claim 52, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 63
Dependent Claim
12 words
A method as in claim 52, wherein the polymeric article is biodegradable.
Claim 64
Dependent Claim
30 words
A method as in claim 52, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 65
Dependent Claim
14 words
A method as in claim 53, wherein the polymeric article contains a therapeutic agent.
Claim 66
Independent Claim
111 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range in a spectrum of between about 300-1000 nm that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 67
Independent Claim
111 words
A method for providing a polymeric material on a tissue surface, comprising: positioning, proximate to a tissue surface, a polymeric article that contains a chromophore having an absorption characteristic; exposing the polymeric article to electromagnetic radiation in a wavelength range in a spectrum of between about 300-1000 nm that matches the absorption characteristic of the chromophore for a period of time sufficient to soften the article; and molding the surface of the article facing the tissue surface into intimate and conforming contact with the tissue surface, the chromophore, polymeric article, and wavelength range of electromagnetic radiation being selected such that the molding is effected under conditions tolerable by the tissue surface.
Claim 68
Dependent Claim
21 words
A method as in claim 58, wherein the wavelength range is in a spectrum of between about 500 and 850 nm.
Claim 69
Dependent Claim
26 words
A method as in claim 58, the method involving paving or stabilizing an irregularly contoured tissue surface of a lumen or hollow organ of a mammal.
Claim 70
Dependent Claim
29 words
A method as in claim 58, wherein the polymeric article is made of material from the group consisting of polymers of caprolactones, anhydrides, lactides, glycolides, oxyalkylenes, and combinations thereof.
Claim 71
Dependent Claim
12 words
A method as in claim 58, wherein the polymeric article is biodegradable.
Claim 72
Dependent Claim
30 words
A method as in claim 58, wherein the molding step is carried out by urging the polymeric article against the tissue surface with a radially expandable portion of a catheter.
Claim 73
Dependent Claim
14 words
A method as in claim 58, wherein the polymeric article contains a therapeutic agent.
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