US5145945A — Homopolymers and copolymers having recurring carb…

Claim 1

Independent Claim 231 words

A random copolymer comprising at least one type of recurring monomeric unit of the following General Structures I and II: ##STR11## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more biologically compatible substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that when said copolymers have recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of copolymer are not derived from gylcolide or glycolic acid.

Claim 2

Dependent Claim 231 words

A random copolymer comprising at least one type of recurring monomeric unit of the following General Structures I and II: ##STR11## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more biologically compatible substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; With the proviso that when said copolymers have recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of copolymer are not derived from gylcolide or glycolic acid.

Claim 3

Dependent Claim 59 words

The random copolymer of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkylphenyl, alkoxyalkyl and phenylalkyl, and phenyl, alkylphenyl and phenylalkyl substituted with one or more alkyl or alkoxy groups.

Claim 4

Dependent Claim 69 words

The random polymer of claim 2 wherein: Z is --C(R 5 R 6 )--, --O-- or a combination thereof; n is 1, 2, or 3; m is 1, 2, 3, 4, 5 or 6; and R 1 to R 6 are selected from the group consisting of substituents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.

Claim 5

Dependent Claim 98 words

The random copolymer of claim 1 comprising at least one type of recurring monomeric unit of the following general Structures II and III: ##STR12## wherein: n is 1 to about 3; m is 1 to about 4; R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are hydrogen, aryl, alkylaryl, arylalkyl or alkyl, or R 5 and R 6 together may form an aliphatic chain having from about 3 to about 10 membered spiro, bicyclic or tricyclic ring structure or a combination thereof.

Claim 6

Dependent Claim 49 words

The block copolymer of claim 4 wherein: n is 1, 2 or 3; m is 1, 2 or 3; and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, alkyl, phenylalkyl or alkylphenyl.

Claim 7

Dependent Claim 42 words

The block copolymer of claim 5 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 7 carbon atoms.

Claim 8

Dependent Claim 21 words

The random copolymer of claim 6 comprising at least one type of recurring monomeric unit of the following Structure III: ##STR13##

Claim 9

Dependent Claim 30 words

The random copolymer of claim 7 wherein R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 4 carbon atoms.

Claim 10

Dependent Claim 43 words

The random copolymer of claim 1 wherein the wt % of recurring monomeric units of the Structure I or Structure II included in said copolymer is at least about 50 wt % based on the total weight of monomeric units in the copolymer.

Claim 11

Dependent Claim 21 words

The random copolymer of claim 9 wherein said wt % is from about 80 wt % to about 100 wt %.

Claim 12

Dependent Claim 19 words

The random copolymer of claim 10 wherein said wt % is from about 85 to about 99 wt %.

Claim 13

Dependent Claim 58 words

The random copolymer of claim 1 wherein said copolymer comprises at least one type of recurring unit of the General Structures I and II, and at least one other type of recurring monomeric unit derived from the group consisting of substituted carbonates, non-substituted carbonates, lactones, dioxepanones, dioxanones other than carbonates, epoxides, epoxide/CO 2 , anhydrides, orthoesters, and orthocarbonates.

Claim 14

Dependent Claim 39 words

The random copolymer of claim 12 wherein said copolymer comprises recurring monomeric units derived from 2,2-dimethyltrimethylene carbonate and at least one other type of recurring monomeric unit derived from orthocarbonates, orthoesters, lactones, trimethylene carbonates, ethylene carbonates or tetramethylene carbonates.

Claim 15

Dependent Claim 24 words

The random copolymer of claim 13 wherein said copolymer comprises recurring monomeric units derived from trimethylene carbonate and recurring monomeric units derived from lactones.

Claim 16

Dependent Claim 62 words

The copolymer of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkylaryl, alkoxyalkyl, aryloxyalkyl, arloxyaryl, aryl and arylalkyl groups, and aryl, arylalkyl or alkylaryl substituted with one or more alkyl, alkoxy and alkoxyalkyl groups.

Claim 17

Dependent Claim 57 words

The copolymer of claim 15 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkylphenyl, alkoxyalkyl and phenylakyl, and phenyl, alkylphenyl and phenylalkyl substituted with one or more alkyl or alkoxy groups.

Claim 18

Dependent Claim 68 words

The copolymer of claim 16 wherein: Z is --C(R 5 R 6 )--, --O-- or a combination thereof; n is 1, 2, or 3; m is 1, 2, 3, 4, 5 or 6; and R 1 to R 6 are selected from the group consisting of substitutents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.

Claim 19

Dependent Claim 48 words

The copolymer of claim 15 wherein: n is 1, 2 or 3; m is 1, 2 or 3; and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, alkyl, phenylalkyl or alkylphenyl.

Claim 20

Dependent Claim 41 words

The copolymer of claim 18 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 7 carbon atoms.

Claim 21

Dependent Claim 133 words

The copolymer of claim 1 wherein said biopolymers comprises at least one type of recurring monomeric unit moieties selected from the group consisting of: ##STR14## wherein: R 5 and R 6 are the same or different and are hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, or aryl or arylalkyl substituted with one or more alkyl, alkoxy, alkanoyl, or dialkylamino groups, or R 5 and R 6 together may form an alkylene chain completing a 4, 5, 5, 7, 8, 9 or 10 membered spiro, bicyclic or tricyclic ring structure or a combination thereof, which structure may optionally include one or more non-adjacent divalent carbonyl, oxa, alkylaza or arylaza groups, with the proviso that at least one or R 5 or R 6 is other than hydrogen; and n is 1, 2 or 3.

Claim 22

Dependent Claim 19 words

The copolymer of claim 20 selected from the group consisting of poly(trimethylene carbonate-co-lactide), poly(dimethyltrimethylene carbonate-co-trimethylene carbonate) and poly(dimethyltrimethylene carbonate-co-caprolactone).

Claim 23

Dependent Claim 4 words

The copolymer poly(trimethylene carbonate-co-lactide).

Claim 24

Dependent Claim 4 words

The copolymer poly(trimethylene carbonate-co-lactide).

Claim 25

Dependent Claim 5 words

The copolymer poly(dimethyltrimethylene carbonate-co-trimethylene carbonate).

Claim 26

Dependent Claim 5 words

The copolymer poly(dimethyltrimethylene carbonate-co-trimethylene carbonate).

Claim 27

Dependent Claim 31 words

The copolymer of claim 22 wherein the weight ratio of dimethyltrimethylene carbonate to trimethylene carbonate in said poly(dimethyltrimethylene carbonate-co-trimethylene carbonate) is from about 25 to 75 to about 97:5 to 2.5.

Claim 28

Dependent Claim 20 words

The copolymer of claim 24 wherein said weight ration is from about 56 to 44 to about 97:5 to 2.5.

Claim 29

Dependent Claim 20 words

The copolymer of claim 25 wherein said weight ratio is from about 79 to 21 to about 97.5 to 2.5.

Claim 30

Dependent Claim 20 words

The copolymer of claim 26 wherein said weight ratio is from about 95 to 5 to about 97.5 to 2.5.

Claim 31

Dependent Claim 42 words

The copolymer of claim 20 wherein R 5 and R 6 are the same or different and are phenyl, phenylalkyl, alkylphenyl, alkyl, or R 5 and R 6 together form alkylene a divalent chain forming a 4 to 8 membered ring structure.

Claim 32

Dependent Claim 27 words

The copolymer of claim 28 wherein R 5 and R 6 together form a 5 to 7 membered spiro, or bicyclic ring structure or a combination thereof.

Claim 33

Dependent Claim 14 words

The copolymer of claim 20 wherein R 5 and R 6 are the same.

Claim 34

Dependent Claim 23 words

The copolymer of claim 30 wherein R 5 and R 6 are the same or different and are alkyl, phenyl, alkylphenyl or phenylalkyl.

Claim 35

Dependent Claim 13 words

The copolymer of claim 20 wherein R 5 and R 6 are hydrogen.

Claim 36

Dependent Claim 27 words

The copolymer of claim 31 wherein R 5 and R 6 are the same or different and are alkyl of from about 1 to 7 carbon atoms.

Claim 37

Dependent Claim 20 words

The copolymer of claim 33 wherein R 5 and R 6 are alkyl of about 1 to 4 carbon atoms.

Claim 38

Dependent Claim 42 words

The copolymer of claim 1 wherein the wt % of recurring monomeric units of the Structure I or Structure II included in said copolymer is at least about 50 wt % based on the total wt of monomeric units in the copolymer.

Claim 39

Dependent Claim 20 words

The copolymer of claim 35 wherein said wt % is from about 80 wt % to about 100 wt %.

Claim 40

Dependent Claim 18 words

The copolymer of claim 36 wherein said wt % is from about 85 to about 100 wt %.

Claim 41

Dependent Claim 18 words

The copolymer of claim 37 wherein said wt % is from about 85 to about 99 wt %.

Claim 42

Dependent Claim 65 words

The copolymer of claim 1 wherein said biopolymers are selected from the group consisting of random copolymers comprising at least one type of recurring unit of the General Structures I and II, and at least other type of recurring monomeric units derived from the group consisting of substituted carbonates, non-substituted carbonates, lactones, dioxepanones, dioxanones other than carbonates, epoxides, epoxide/CO 2 , anhydrides, orthoesters, and orthocarbonates.

Claim 43

Dependent Claim 35 words

The copolymer of claim 1 wherein said copolymer comprises recurring monomeric units derived from 2,2-dimethyltrimethylene carbonate and other types of recurring monomeric units derived from orthocarbonates, orthoesters, lactones, trimethylene carbonates, ethylene carbonates and tetramethylene carbonates.

Claim 44

Dependent Claim 26 words

The copolymer of claim 1 wherein said copolymer comprises recurring monomeric units derived from trimethylene carbonate and other types of recurring monomeric units derived from lactones.

Claim 45

Dependent Claim 29 words

The device of claim 1 which is a totally or partially bioresorbable medical device suitable for implantation in side of a living system to promote regeneration of body tissue.

Claim 46

Dependent Claim 11 words

The device of claim 1 which further comprises a biodurable portion.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1995-09-08	1996-03-09	1996-09-08	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1999-09-08	2000-03-09	2000-09-08	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2003-09-08	2004-03-09	2004-09-08	$7700.00	Window Closed / Lapsed

Homopolymers and copolymers having recurring carbonate units

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