US4920203A — Medical devices fabricated from homopolymers and …

Claim 1

Independent Claim 264 words

A medical device formed totally or in part of one or more biopolymers selected from the group consisting of block copolymers having at least one type of recurring monomeric unit of the following General Structures I and II: ##STR12## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more substituents selected from the group consisting of alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino, and alkylarylamino; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said biopolymers are copolymer having recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of the copolymer are not derived from gylcolide or glycolic acid.

Claim 2

Dependent Claim 264 words

A medical device formed totally or in part of one or more biopolymers selected from the group consisting of block copolymers having at least one type of recurring monomeric unit of the following General Structures I and II: ##STR12## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more substituents selected from the group consisting of alkyl, aryl, alkoxy, aryloxy, dialkylamino, diarylamino, and alkylarylamino; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said biopolymers are copolymer having recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of the copolymer are not derived from gylcolide or glycolic acid.

Claim 3

Dependent Claim 62 words

The device of claim 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkylaryl, alkoxyalkyl, aryloxyalkyl, aryloxyaryl, aryl and arylalkyl groups, and aryl, arylalkyl or alkylaryl substituted with one or more alkyl, alkoxy and alkoxyalkyl groups.

Claim 4

Dependent Claim 57 words

The device of claim 2 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkylphenyl, alkoxyalkyl and phenylalkyl, and phenyl, alkylphenyl and phenylalkyl substituted with one or more alkyl or alkoxy groups.

Claim 5

Dependent Claim 68 words

The device of claim 3 wherein: Z is --C(R 5 R 6 )--, --O-- or a combination thereof; n is 1, 2, or 3; m is 1, 2, 3, 4, 5 or 6; and R 1 to R 6 are selected from the group consisting of substitutents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.

Claim 6

Dependent Claim 100 words

The device of claim 1 wherein said biopolymers comprise at least one type of recurring monomeric units of the following general Structures II and III: ##STR13## wherein: n is 1 to about 3; m is 1 to about 4; R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are hydrogen, aryl, alkylaryl, arylalkyl or alkyl, or R 5 and R 6 together may form an aliphatic chain having from about 3 to about 10 membered spiro, bicyclic, or tricyclic ring structure or a combination thereof.

Claim 7

Dependent Claim 48 words

The device of claim 5 wherein: n is 1, 2 or 3; m is 1, 2 or 3; and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, alkyl, phenylalkyl or alkylphenyl.

Claim 8

Dependent Claim 41 words

The device of claim 6 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 7 carbon atoms.

Claim 9

Dependent Claim 134 words

The device of claim 1 wherein the biopolymers comprises at least one type of recurring monomeric unit moieties selected from the group consisting of: ##STR14## wherein: R 5 and R 6 are the same or different and are hydrogen, alkyl, aryl, cycloalkyl, arylalkyl, alkoxyalkyl, aryloxyalkyl, or aryl or arylalkyl substituted with one or more alkyl or alkoxy groups alkoxy, alkanoyl, dialkylamino, or R 5 and R 6 together may form an alkylene chain completing a 4, 5, 6, 7, 8, 9 or 10 membered spiro, bicyclic, or tricyclic ring structure or a combination thereof, which structure may optionally include one or more non-adjacent divalent carbonyl, oxa, alkylaza or arylaza groups with the proviso that at least one of R 5 or R 6 is other than hydrogen; and n is 1, 2 or 3.

Claim 10

Dependent Claim 42 words

The device of claim 8 wherein R 5 and R 6 are the same or different and are phenyl, phenylalkyl, alkylphenyl, alkyl, or R 5 and R 6 together form alkylene a divalent chain forming a 4 to 8 membered ring structure.

Claim 11

Dependent Claim 27 words

The device of claim 9 wherein R 5 and R 6 together form a 5 to 7 membered spiro, or bicyclic ring structure or a combination thereof.

Claim 12

Dependent Claim 14 words

The device of claim 8 wherein R 5 and R 6 are the same.

Claim 13

Dependent Claim 23 words

The device of claim 11 wherein R 5 and R 6 are the same or different and are alkyl, phenyl, alkylphenyl or phenylalkyl.

Claim 14

Dependent Claim 13 words

The device of claim 8 wherein R 5 and R 6 are hydrogen.

Claim 15

Dependent Claim 27 words

The device of claim 12 wherein R 5 and R 6 are the same or different and are alkyl of from about 1 to 7 carbon atoms.

Claim 16

Dependent Claim 20 words

The device of claim 13 wherein R 5 and R 6 are alkyl of about 1 to 4 carbon atoms.

Claim 17

Dependent Claim 42 words

The device of claim 1 wherein the wt % of recurring monomeric units of the Structure I or Structure II included in said copolymer is at least about 50 wt % based on the total wt of monomeric units in the copolymer.

Claim 18

Dependent Claim 20 words

The device of claim 16 wherein said wt % is from about 80 wt % to about 100 wt %.

Claim 19

Dependent Claim 18 words

The device of claim 17 wherein said wt % is from about 85 to about 100 wt %.

Claim 20

Dependent Claim 18 words

The device of claim 18 wherein said wt % is from about 85 to about 99 wt %.

Claim 21

Dependent Claim 64 words

The device of claim 1 wherein said biopolymers are selected from the group consisting of copolymers comprising at least one type of recurring unit of the General Structures I and II, and at least other type of recurring monomeric units derived from the group consisting of substituted carbonates, non-substituted carbonates, lactones, dioxepanones, dioxanones other than carbonates, epoxides, epoxide/CO 2 , anhydrides, orthoesters, and orthocarbonates.

Claim 22

Dependent Claim 36 words

The device of claim 1 wherein said copolymer comprises recurring monomeric units derived from 2, 2-dimethyltrimethylene carbonate and other types of recurring monomeric units derived from orthocarbonates, orthoesters, lactones, trimethylene carbonates, ethylene carbonates and tetramethylene carbonates.

Claim 23

Dependent Claim 26 words

The device of claim 1 wherein said copolymer comprises recurring monomeric units derived from trimethylene carbonate and other types of recurring monomeric units derived from lactones.

Claim 24

Dependent Claim 29 words

The device of claim 1 which is a totally or partially bioresorbable medical device suitable for implantation in side of a living system to promote regeneration of body tissue.

Claim 25

Dependent Claim 11 words

The device of claim 1 which further comprises a biodurable portion.

Claim 26

Dependent Claim 231 words

A block copolymer comprising at least one type of recurring monomeric unit of the following General Structures I and II: ##STR15## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more biologically compatible substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said copolymers have recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of copolymer are not derived from gylcolide or glycolic acid.

Claim 27

Dependent Claim 231 words

A block copolymer comprising at least one type of recurring monomeric unit of the following General Structures I and II: ##STR15## wherein: Z is --C(R 5 R 6 )--, --NR 5 --, --O-- or a combination thereof, where Z is selected such that there are no adjacent heteroatoms; n is from 1 to about 8; m is from 1 to about 8; R 1 , R 2 , R 3 , and R 4 are the same or different at each occurrence and are hydrogen, aryloxyalkyl, alkyoxyaryl, aryloxyaryl, arylalkyl, alkylarylalkyl, arylalkylaryl, alkylaryl, arylcarbonylalkyl, alkyl, aryl, alkylcarbonyalkyl, cycloalkyl, arylcarbonylaryl, alkylcarbonylarly, alkoxyalkyl, or aryl or alkyl substituted with one or more biologically compatible substituents; and R 5 and R 6 are the same or different and are R 1 , R 2 , R 3 , R 4 , dialkylamino, diarylamino, alkylarylamino, alkoxy, aryloxy, alkanoyl, or arylcarbonyl, or any two of R 1 to R 6 together may form an alkylene chain completing a 3, 4, 5, 6, 7, 8 or 9 membered alicyclic fused, spiro, bicyclic or tricyclic ring system or a combination thereof, which system may optionally include one or more non-adjacent carbonyl, oxa, alkylaza or arylaza groups; with the proviso that when said copolymers have recurring units of the Structure I derived from trimethylene carbonate, the other recurring monomeric units of copolymer are not derived from gylcolide or glycolic acid.

Claim 28

Dependent Claim 59 words

The block copolymer of claim 25 wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are selected from the groups consisting of hydrogen, alkyl, cycloalkyl, alkylphenyl, alkoxyalkyl and phenylalkyl, and phenyl, alkylphenyl and phenylalkyl substituted with one or more alkyl or alkoxy groups.

Claim 29

Dependent Claim 69 words

The block polymer of claim 26 wherein: Z is --C(R 5 R 6 )--, --O-- or a combination thereof; n is 1, 2, or 3; m is 1, 2, 3, 4, 5 or 6; and R 1 to R 6 are selected from the group consisting of substituents in which aliphatic moieties include up to about 10 carbon atoms and aryl moieties include up to about 16 carbon atoms.

Claim 30

Dependent Claim 98 words

The block copolymer of claim 25 comprising at least one type of recurring monomeric unit of the following general Structures II and III: ##STR16## wherein: n is 1 to about 3; m is 1 to about 4; R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are the same or different and are hydrogen, aryl, alkylaryl, arylalkyl or alkyl, or R 5 and R 6 together may form an aliphatic chain having from about 3 to about 10 membered spiro, bicyclic or tricyclic ring structure or a combination thereof.

Claim 31

Dependent Claim 49 words

The block copolymer of claim 28 wherein: n is 1, 2 or 3; m is 1, 2 or 3; and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen, alkyl, phenylalkyl or alkylphenyl.

Claim 32

Dependent Claim 42 words

The block copolymer of claim 29 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 7 carbon atoms.

Claim 33

Dependent Claim 21 words

The block copolymer of claim 30 comprising at least one type of recurring monomeric unit of the following Structure III: ##STR17##

Claim 34

Dependent Claim 30 words

The block copolymer of claim 31 wherein R 5 and R 6 are the same or different and are hydrogen or alkyl having from 1 to about 4 carbon atoms.

Claim 35

Dependent Claim 43 words

The block copolymer of claim 25 wherein the wt % of recurring monomeric units of the Structure I or Structure II included in said copolymer is at least about 50 wt % based on the total weight of monomeric units in the copolymer.

Claim 36

Dependent Claim 21 words

The block copolymer of claim 33 wherein said wt % is from about 80 wt % to about 100 wt %.

Claim 37

Dependent Claim 19 words

The block copolymer of claim 34 wherein said wt % is from about 85 to about 99 wt %.

Claim 38

Dependent Claim 58 words

The block copolymer of claim 25 wherein said copolymer comprises at least one type of recurring unit of the General Structures I and II, and at least one other type of recurring monomeric unit derived from the group consisting of substituted carbonates, non-substituted carbonates, lactones, dioxepanones, dioxanones other than carbonates, epoxides, anhydrides, epoxide/CO 2 , orthoesters, and orthocarbonates.

Claim 39

Dependent Claim 40 words

The block copolymer of claim 36 wherein said copolymer comprises recurring monomeric units derived from 2, 2-dimethyltrimethylene carbonate and at least one other type of recurring monomeric unit derived from orthocarbonates, orthoesters, lactones, trimethylene carbonates, ethylene carbonates or tetramethylene carbonates.

Claim 40

Dependent Claim 24 words

The block copolymers of claim 37 wherein said copolymer comprises recurring monomeric units derived from trimethylene carbonate and recurring monomeric units derived from lactones.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1993-04-23	1993-10-23	1994-04-24	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1997-04-23	1997-10-23	1998-04-24	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2001-04-23	2001-10-23	2002-04-24	$7700.00	Window Closed / Lapsed

Medical devices fabricated from homopolymers and copolymers having recurring carbonate units

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