US5844016A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Redox and photoinitiator priming for improved adherence of gels to substrates
Assignee: Genzyme Corp
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Filing: 1995-06-07
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Granted: 1998-12-01
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Expires: 2015-06-07
Abstract
Abstract An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.
Inventors
- 👤 Amarpreet S. Sawhney
- 👤 David A. Melanson
- 👤 Chandrashekar P. Pathak
- 👤 Jeffrey A. Hubbell
- 👤 Luis Z. Avila
- 👤 Mark T. Kieras
- 👤 Stephen D. Goodrich
- 👤 Shikha P. Barman
- 👤 Arthur J. Coury
- 👤 Ronald S. Rudowsky
- 👤 Douglas J. K. Weaver
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 08:37
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/0031; A61L24/0015; A61L24/0042; A61L24/04; A61L24/046; A61L24/06; C; C08; C08F; C08F2/00; C08F2/46; C08F2/48; C08F265/00; C08F265/04; C08F271/00; C08F283/00; C08F289/00; C08F290/00; C08F290/02; C08F290/06; C08F290/062; C08F290/08; C08F290/14; C08F291/00; C09; C09D; C09D4/00; C09J; C09J151/00; A61B; A61B17/00; A61B17/00491; A61B17/08; A61B17/085; A61B2017/00495; A61L2300/00; C08L; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S602/00; Y10S602/90; Y10S602/904
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
98 words
A composition for forming a hydrogel comprising an aqueous solution which includes: a) a photoinitiation system, comprising one or more components selected from the group consisting of photoinitiators, photosensitizers and co-initiators, b) an amine or amide electron transfer agent; c) a redox accelerant system for the photoinitiation system, comprising a metal ion and a peroxide; and d) a photopolymerizable macromer solution; wherein the macromers are biocompatible, non-toxic to cells, and water-soluble, and contain on average more than one ethylenically-unsaturated photopolymerizable group; wherein the solution is curable to a hydrogel upon exposure to light at room or body temperature.
Claim 2
Dependent Claim
98 words
A composition for forming a hydrogel comprising an aqueous solution which includes: a) a photoinitiation system, comprising one or more components selected from the group consisting of photoinitiators, photosensitizers and co-initiators, b) an amine or amide electron transfer agent; c) a redox accelerant system for the photoinitiation system, comprising a metal ion and a peroxide; and d) a photopolymerizable macromer solution; wherein the macromers are biocompatible, non-toxic to cells, and water-soluble, and contain on average more than one ethylenically-unsaturated photopolymerizable group; wherein the solution is curable to a hydrogel upon exposure to light at room or body temperature.
Claim 3
Dependent Claim
40 words
The composition of claim 1 wherein the redox accelerant system requires more than an hour to polymerize a monomer or macromer to form a gel in the absence of light when a monomer or macromer is added to the composition.
Claim 4
Dependent Claim
11 words
The composition of claim 1 further comprising a biologically active substance.
Claim 5
Dependent Claim
35 words
The composition of claim 3 in which the biologically active substance is selected from the group consisting of proteins, peptides, organic synthetic molecules, inorganic compounds, natural extracts, nucleic acids, lipids, carbohydrates, glycoproteins and combinations thereof.
Claim 6
Independent Claim
128 words
A method for formation of a hydrogel on a surface, comprising: a) applying to one or more surfaces an aqueous solution which comprises: i) a photoinitiation system, comprising one or more components selected from the group consisting of photoinitiators, photosensitizers and co-initiators; ii) an amine or amide electron transfer agent; iii) a redox accelerant system for the photoinitiation system, comprising a metal ion and a peroxide; and iv) a photopolymerizable macromer solution; wherein the macromers are biocompatible, non-toxic to cells, and water-soluble, and contain on average more than one ethylenically-unsaturated photopolymerizable group; wherein the solution is curable to a hydrogel by exposure to light at room or body temperature; and b) applying UV or visible light to the solution on the surface to a hydrogel on the surface.
Claim 7
Independent Claim
128 words
A method for formation of a hydrogel on a surface, comprising: a) applying to one or more surfaces an aqueous solution which comprises: i) a photoinitiation system, comprising one or more components selected from the group consisting of photoinitiators, photosensitizers and co-initiators; ii) an amine or amide electron transfer agent; iii) a redox accelerant system for the photoinitiation system, comprising a metal ion and a peroxide; and iv) a photopolymerizable macromer solution; wherein the macromers are biocompatible, non-toxic to cells, and water-soluble, and contain on average more than one ethylenically-unsaturated photopolymerizable group; wherein the solution is curable to a hydrogel by exposure to light at room or body temperature; and b) applying UV or visible light to the solution on the surface to a hydrogel on the surface.
Claim 8
Dependent Claim
14 words
The method of claim 5 wherein the solution further comprises a biologically active substance.
Claim 9
Dependent Claim
35 words
The method of claim 6 in which the biologically active substance is selected from the group consisting of proteins, peptides, organic synthetic molecules, inorganic compounds, natural extracts, nucleic acids, lipids, carbohydrates, glycoproteins and combinations thereof.
Claim 10
Dependent Claim
30 words
The method of claim 5, wherein the surface is selected from the group consisting of tissue surfaces, the surface of a medical device, and the surface of a polymeric film.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-11-30 | 2002-06-01 | 2002-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-11-30 | 2006-06-01 | 2006-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-11-30 | 2010-06-01 | 2010-12-01 | $7700.00 | Window Closed / Lapsed |