Planar separation column for use in sample analysis system

Claim 2

A multilayer integrated assembly for effecting fluid handling functions for use in a sample analysis system, comprising: a planar foldable substrate having n component sections and (n-1) linear fold means defining a plurality of (n-1) fold axes, wherein n equals three or more, wherein the component sections are closed upon one another in a Z-fold configuration upon performing a folding action along the (n-1) fold axes of said (n-1) linear fold means, thereby having a first linear fold means, the first linear fold means defining a linear fold axis and first and second component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis to form a separation column in a unitary planar assembly; inlet and outlet apertures respectively communicating with inlet and outlet ends of the separation column for effecting sample fluid flow in the separation column; and a surface treatment in at least one of the first and second channels; whereby the multilayer integrated assembly is useable for effecting separation of the sample fluid into its constituent components during said sample fluid flow.

Claim 3

The integrated assembly of claim 1, wherein the first and second mating surfaces are susceptible to diffusion bonding at a desired diffusion bonding temperature.

Claim 4

The integrated assembly of claim 2, further comprising a surface feature on one of said first and second component sections and wherein the surface feature further includes a surface defect, and further comprising a surface layer in at least one of the first and second mating surfaces , said surface layer being formulated to melt at the desired diffusion bonding temperature, thus forming an amount of transient liquid phase, whereby the formation of the amount of the transient liquid phase altersthe surface defect.

Claim 5

The integrated assembly of claim 3, wherein the surface defect is located at the interface of the first and second mating surfaces.

Claim 6

The integrated assembly of claim 4, wherein the first and second mating surfaces further comprise complementary microstructures.

Claim 7

The integrated assembly of claim 4, wherein the first and second channels further comprise complementary microstructures and further comprising means for inhibiting flow of the transient liquid phase into the separation column.

Claim 8

The integrated assembly of claim 1, wherein the linear fold means includes a fold relief for relieving stress or deformation induced in the substrate in the immediate area of the fold axis during operation of the linear fold means.

Claim 9

The integrated assembly of claim 1, further comprising corroboration means for corroborating the alignment of the first and second channels.

Claim 10

A sample analysis system, comprising: an integrated assembly in the form of a planar separation column device for use in separation of a sample present in a sample fluid, having a planar foldable substrate that includes n component sections and (n-1) linear fold means defining a plurality of (n-1) fold axes, wherein n equals three or more, and wherein the component sections are closed upon one another in a Z-fold configuration upon performing a folding action along the (n-1) fold axes of said (n-1) linear fold means, thereby including a first linear fold means defining a linear fold axis and first and second component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces and wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis to form a separation column in a unitary planar assembly, and inlet and outlet apertures respectively communicating with the separation column for providing sample fluid flow in the separation column; and a surface treatment in at least one of the first and second channels, whereby the integrated assembly is useable for effecting separation of the sample fluid into its constituent components during said sample fluid flow; an inlet mounted to the integrated assembly and communicating with the inlet aperture; a detector mounted to the integrated assembly and communicating with the outlet aperture; and motive means for effecting sample fluid flow from the inlet through the separation column to the detector.

Claim 11

A sample analysis system, comprising: an integrated assembly in the form of a planar separation column device for use in separation of a sample present in a sample fluid, having a planar foldable substrate that includes n component sections and (n-1) linear fold means defining a plurality of (n-1) fold axes, wherein n equals three or more, and wherein the component sections are closed upon one another in a Z-fold configuration upon performing a folding action along the (n-1) fold axes of said (n-1) linear fold means, thereby including a first linear fold means defining a linear fold axis and first and second component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces and wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis to form a separation column in a unitary planar assembly, and inlet and outlet apertures respectively communicating with the separation column for providing sample fluid flow in the separation column; and a surface treatment in at least one of the first and second channels, whereby the integrated assembly is useable for effecting separation of the sample fluid into its constituent components during said sample fluid flow; an inlet mounted to the integrated assembly and communicating with the inlet aperture; a detector mounted to the integrated assembly and communicating with the outlet aperture; and motive means for effecting sample fluid flow from the inlet through the separation column to the detector.

Claim 12

The integrated assembly of claim 1, wherein the planar foldable substrate further comprises a surface feature selected from the group consisting of: a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

Claim 13

The integrated assembly of claim 1, wherein the surface treatment is selected from the group consisting of: a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, opto-electrical, magneto-optical, or magnetic characteristic.

Claim 14

The integrated assembly of claim 1, wherein said planar foldable substrate is comprised of a material that is ductile in the region of the linear fold means and substantially inextensible in the first and second component sections.

Claim 15

The integrated assembly of claim 1, wherein an intermediary substrate is interposed between at least two of the component sections.

Claim 16

The integrated assembly of claim 13, wherein the intermediary substrate further comprises a surface feature selected from the group consisting of: a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

Claim 17

The integrated assembly of claim 13, wherein the intermediary substrate includes a surface treatment selected from the group consisting of: a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, optoelectrical, magneto-optical, or magnetic characteristic.

Claim 18

The integrated assembly of claim 13, wherein at least one of the intermediary substrate and the planar foldable substrate further comprises corroboration means for corroborating the alignment of the intermediary substrate and the planar foldable substrate.

Claim 19

The integrated assembly of claim 2, further comprising an intermediary substrate interposed between at least two of the component sections of the planar foldable substrate and wherein the intermediary substrate and the first and second component sections are susceptible to diffusion bonding at a desired diffusion bonding temperature.

Claim 20

The integrated assembly of claim 1, wherein the planar foldable substrate further comprises a substrate material selected from the group consisting of: metal, metal alloy, steel, and stainless steel.

Claim 21

A multilayer integrated assembly for effecting fluid handling functions for use in a sample analysis system, comprising: a planar foldable substrate having a linear fold means, the linear fold means defining a linear fold axis and first and second component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces, wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis and said first and second mating surfaces are subject to diffusion bonding at a desired diffusion bonding temperature to form a separation column in a unitary planar assembly; and inlet and outlet apertures respectively communicating with inlet and outlet ends of the separation column for effecting sample fluid flow in the separation column; whereby the integrated assembly is useable for effecting separation of the sample fluid into its constituent components during said sample fluid flow.

Claim 22

A multilayer integrated assembly for effecting fluid handling functions for use in a sample analysis system, comprising: a planar foldable substrate having a linear fold means, the linear fold means defining a linear fold axis and first and second component sections, wherein said first and second component sections include respective first and second channels on respective first and second mating surfaces, wherein the first and second channels are aligned and superimposed by folding the substrate at the linear fold axis and said first and second mating surfaces are subject to diffusion bonding at a desired diffusion bonding temperature to form a separation column in a unitary planar assembly; and inlet and outlet apertures respectively communicating with inlet and outlet ends of the separation column for effecting sample fluid flow in the separation column; whereby the integrated assembly is useable for effecting separation of the sample fluid into its constituent components during said sample fluid flow.

Claim 23

The integrated assembly of claim 19, further comprising n component sections and (n-1) linear fold means defining a plurality of (n-1) fold axes, wherein n equals three or more, and wherein the component sections are closed upon one another in a Z-fold configuration upon performing a folding action along the (n-1) fold axes of said (n-1) linear fold means.

Claim 24

The integrated assembly of claim 19, further comprising a surface feature on one of said first and second mating surfaces and wherein the surface feature further includes a surface defect, and further comprising a surface layer in at least one of the first and second mating surfaces, said surface layer being formulated to melt at the desired diffusion bonding temperature, thus forming an amount of transient liquid phase, whereby the formation of the amount of the transient liquid phase alters the surface defect.

Claim 25

The integrated assembly of claim 21, wherein the surface defect is located at the interface of the first and second mating surfaces.

Claim 26

The integrated assembly of claim 21, wherein the first and second channels further comprise complementary microstructures, and further comprising means for inhibiting flow of the transient liquid phase into the separation column.

Claim 27

The integrated assembly of claim 19, wherein the linear fold means includes a fold relief for relieving stress or deformation induced in the substrate in the immediate area of the fold axis during operation of the linear fold means.

Claim 28

The integrated assembly of claim 19, further comprising corroboration means for corroborating the alignment of the first and second channels.

Claim 29

The integrated assembly of claim 19, wherein at least one of the first and second component sections further comprises a surface feature selected from the group consisting of: a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

Claim 30

The integrated assembly of claim 19, wherein at least one of the first and second component sections further comprises a surface treatment selected from the group consisting of: a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, opto-electrical, magneto-optical, or magnetic characteristic.

Claim 31

The integrated assembly of claim 19, wherein said planar foldable substrate is comprised of a material that is ductile in the region of the linear fold means and substantially inextensible in the first and second component sections.

Claim 32

The integrated assembly of claim 19, wherein an intermediary substrate is interposed between the first and second component sections.

Claim 33

The integrated assembly of claim 29, wherein the intermediary substrate further comprises a surface feature selected from the group consisting of: a microstructure, conductor, semiconductor, insulator, electrode, sensor, sensor array, catalyst, orifice, screen, well, restriction, frit, perforation, porous section, permeable region, and semi-permeable region.

Claim 34

The integrated assembly of claim 29, wherein the intermediary substrate includes a surface treatment selected from the group consisting of: a chemically-active region, a biologically-active region, and a region having at least one optical, electrical, optoelectrical, magneto-optical, or magnetic characteristic.

Claim 35

The integrated assembly of claim 29, wherein at least one of the intermediary substrate and the planar foldable substrate further comprises corroboration means for corroborating the alignment of the intermediary substrate and the planar foldable substrate.

Claim 36

The integrated assembly of claim 29, wherein the intermediary substrate and the first and second mating surfaces are susceptible to diffusion bonding at a desired diffusion bonding temperature.

Claim 37

The integrated assembly of claim 29, further comprising: a surface feature on at least one of said intermediary substrate and said first and second mating surfaces, wherein the surface feature further includes a surface defect, each of said intermediary substrate, first mating surface, and second mating surface having a respective surface layer, said respective surface layers being formulated to melt at the desired diffusion bonding temperature, thus forming an amount of transient liquid phase, whereby the formation of the amount of the transient liquid phase alters the surface defect.

Claim 38

The integrated assembly of claim 19, further comprising: an inlet attached to the planar foldable substrate and communicating with the inlet aperture; a detector attached to the planar foldable substrate and communicating with the outlet aperture; and motive means coupled to the separation column for effecting sample fluid flow from the inlet through the separation column to the detector.