Patent US5773457A successfully refreshed from Google Patents.
US5773457A
Expired / Lapsed
US
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Compositions
Assignee: Individual
•
Filing: 1995-05-18
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Granted: 1998-06-30
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Expires: 2015-05-18
Abstract
Abstract The present invention involves the novel use of various classes of drugs, such as H 2 and H 3 agonists, as erectogenic agents in the treatment of male and female sexual dysfunction.
Inventors
- 👤 Cesar Roberto Dias Nahoum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:14
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/50; A61K31/13; A61K31/155; A61K31/41; A61K31/415; A61K31/4164; A61K31/417; A61K31/4178; A61K31/425; A61K31/427; A61K31/435; A61K31/44; A61K31/4427; A61K31/4439; A61K31/47; A61K31/485; A61K33/00; A61K33/24; A61K33/26; A61K45/00; A61K45/06
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
26 words
A method of treating sexual dysfunction in a mammal in need thereof which comprises administering to said mammal an effective amount of an H 3 agonist.
Claim 2
Independent Claim
26 words
A method of treating sexual dysfunction in a mammal in need thereof which comprises administering to said mammal an effective amount of an H 3 agonist.
Claim 3
Dependent Claim
80 words
The method according to claim 1 wherein the H 3 agonist is of the formula ##STR15## wherein R 1 , R 2 , R 3 and R 4 are each hydrogen or methyl, or R 1 and R 2 taken together represent a methylene, and R 3 is hydrogen, a methyl or a carboxy with the proviso that R 1 , R 2 , R 3 and R 4 are not simultaneously methyl groups, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
17 words
The method according to claim 2 wherein the compound is R-α-methylhistamine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
66 words
The method according to claim 1 wherein the H 3 agonist is further administered in combination with one or more therapeutically active which are an H 2 agonist, histamine, an α-adrenergic blocker, a dopamine D 2 -antagonist, nitric oxide releaser, cyclooxgenase inhibitors, H 1 antagonists, prostaglandin or an analog thereof having a vasoactive function, calcium antagonists, CGRP, VIP, phentolamine, physiostigmine, neostigmine, hydralazine, sodium nitroprusside, or phenoxybenzamine.
Claim 6
Dependent Claim
26 words
The method according to claim 1 which further comprises administering the H 3 agonist with a second therapeutic agent which either facilitates, potentiates or is erectogenic.
Claim 7
Dependent Claim
55 words
The method according to claim 5 wherein the the second therapeutic agent is an H 2 agonist, histamine, an α-adrenergic blocker, a dopamine D 2 -antagonist, nitric oxide releaser, prostaglandin or an analog thereof having a vasoactive function, calcium antagonists, CGRP, VIP, phentolamine, cyclooxgenase inhibitors, H 1 antagonists, physiostigmine, neostigmine, hydralazine, sodium nitroprusside, or phenoxybenzamine.
Claim 8
Dependent Claim
24 words
The method according to claim 5 wherein the second therapeutic agent is an H 2 agonist, sulpiride, papaverine, PGE 1 , phentolamine, or histamine.
Claim 9
Dependent Claim
16 words
The method according to claim 1 wherein the composition is administered intracavernous, topically, transdermally, or intraurethrally.
Claim 10
Dependent Claim
19 words
The method according to claim 4 which further comprises administering with the H 3 agonist a penetration enhancing agent.
Claim 11
Dependent Claim
36 words
Unit dose packaging of a single use i.c. injection wherein said unit dose packaging contains an effective amount of from about 1500 mcg to about 15,000 mcg of an H 3 receptor agonist that promotes erection.
Claim 12
Dependent Claim
36 words
Unit dose packaging of a single use i.c. injection wherein said unit dose packaging contains an effective amount of from about 1500 mcg to about 15,000 mcg of an H 3 receptor agonist that promotes erection.
Claim 13
Dependent Claim
36 words
Unit dose packaging of a single use i.c. injection wherein said unit dose packaging contains an effective amount of from about 4500 mcg to about 9,000 mcg of an H 3 receptor agonist that promotes erection.
Claim 14
Dependent Claim
36 words
Unit dose packaging of a single use i.c. injection wherein said unit dose packaging contains an effective amount of from about 4500 mcg to about 9,000 mcg of an H 3 receptor agonist that promotes erection.
Claim 15
Dependent Claim
13 words
The method according to claim 1 wherein the mammal is a human being.
Claim 16
Dependent Claim
16 words
The method according to claim 1 which method is applied to animals in the veterinary sciences.
Claim 17
Dependent Claim
21 words
An intracavernousal composition which composition comprises an effective amount of an H 3 agonist and a pharmaceutically acceptable carrier or diluent.
Claim 18
Dependent Claim
21 words
An intracavernousal composition which composition comprises an effective amount of an H 3 agonist and a pharmaceutically acceptable carrier or diluent.
Claim 19
Dependent Claim
21 words
An intraurethral composition, which composition comprises an effective amount of an H 3 agonist and a pharmaceutically acceptable carrier or diluent.
Claim 20
Dependent Claim
21 words
An intraurethral composition, which composition comprises an effective amount of an H 3 agonist and a pharmaceutically acceptable carrier or diluent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-29 | 2001-12-29 | 2002-06-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-29 | 2005-12-29 | 2006-06-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-29 | 2009-12-29 | 2010-06-30 | $7700.00 | Window Closed / Lapsed |