Pharmaceutical insertion compositions and a process for producing the same

Claim 1

A method of administering a pharmaceutical composition to the human body comprising inserting into the rectum, vagina or urethra a pharmaceutical insertion composition consisting essentially of a mixture of: (a) 0.1 to 5.0% by weight of a carboxyvinyl polymer in the form of an aqueous solution; (b) A water-soluble basic compound for neutralizing said carboxyvinyl polymer to adjust the preparation to a pH value of 4 to 10, said water-soluble basic compound selected from the group consisting of an alkylamine, a dialkylamine, an alkanolamine, a dialkanolamine, a trialkanolamine, trimethylolaminomethane, ammonia and an alkali metal hydroxide, wherein said alkyl and alkanol each have 1 to 6 carbon atoms; (c) a pharmaceutically effective amount of a pharmaceutical ingredient selected from the group consisting of insulin and an anti-inflammatory and analgesic compound selected from ibuprofen, ketoprofen, flurbiprofen and dichlofenac sodium; said composition being a gel having a pH value of from 4 to 10 and a viscosity of from 5,000 to 100,000 centipoises at 20° C., whereby the pharmaceutical ingredient is absorbed through the rectal, vaginal or urethral tissue into the blood stream of the human body.

Claim 2

A method of administering a pharmaceutical composition to the human body comprising inserting into the rectum, vagina or urethra a pharmaceutical insertion composition consisting essentially of a mixture of: (a) 0.1 to 5.0% by weight of a carboxyvinyl polymer in the form of an aqueous solution; (b) A water-soluble basic compound for neutralizing said carboxyvinyl polymer to adjust the preparation to a pH value of 4 to 10, said water-soluble basic compound selected from the group consisting of an alkylamine, a dialkylamine, an alkanolamine, a dialkanolamine, a trialkanolamine, trimethylolaminomethane, ammonia and an alkali metal hydroxide, wherein said alkyl and alkanol each have 1 to 6 carbon atoms; (c) a pharmaceutically effective amount of a pharmaceutical ingredient selected from the group consisting of insulin and an anti-inflammatory and analgesic compound selected from ibuprofen, ketoprofen, flurbiprofen and dichlofenac sodium; said composition being a gel having a pH value of from 4 to 10 and a viscosity of from 5,000 to 100,000 centipoises at 20° C., whereby the pharmaceutical ingredient is absorbed through the rectal, vaginal or urethral tissue into the blood stream of the human body.