Patent US5770697A successfully refreshed from Google Patents.
US5770697A
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Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
Assignee: Syntro Corp
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Filing: 1995-06-07
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Granted: 1998-06-23
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Expires: 2015-06-07
Abstract
Abstract Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
Inventors
- 👤 Franco A. Ferrari
- 👤 Charles Richardson
- 👤 James Chambers
- 👤 Stuart Causey
- 👤 Thomas J. Pollock
- 👤 Joseph Cappello
- 👤 John W. Crissman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 16:08
CPC Classifications
C; C12; C12N; C12N15/00; C12N15/09; C12N15/11; C12N15/62; C07; C07K; C07K14/00; C07K14/435; C07K14/43504; C07K14/43563; C07K14/43586; C07K14/78; C12N1/00; C12N1/06; C12N15/63; C12N15/70; C12N15/74; C12N15/75; C07K2319/00; C07K2319/01; C07K2319/02; C07K2319/61
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
67 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
Claim 2
Dependent Claim
67 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
Claim 3
Dependent Claim
22 words
The recombinantly produced protein according to claim 1, wherein said repeating unit is of from 3 to 15 amino acids in length.
Claim 4
Dependent Claim
22 words
The recombinantly produced protein according to claim 1, wherein said repeating unit is of from 3 to 9 amino acids in length.
Claim 5
Dependent Claim
23 words
The recombinantly produced protein according to claim 1, wherein said repeating units are in blocks of at least 2 tandemly repeated repeating units.
Claim 6
Dependent Claim
32 words
The recombinantly produced protein according to claim 4, wherein said protein comprises an intervening group of from 1 to 50 amino acids in length between said blocks of tandemly repeated repeating units.
Claim 7
Dependent Claim
78 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein selected from the group consisting of collagen, elastin, silk, and keratin, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
Claim 8
Dependent Claim
78 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein selected from the group consisting of collagen, elastin, silk, and keratin, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein.
Claim 9
Dependent Claim
23 words
The recombinantly produced protein according to claim 6, wherein said repeating units are in blocks of at least 2 tandemly repeated repeating units.
Claim 10
Dependent Claim
32 words
The recombinantly produced protein according to claim 7, wherein said protein comprises an intervening group of from 1 to 50 amino acids in length between said blocks of tandemly repeated repeating units.
Claim 11
Dependent Claim
27 words
The recombinantly produced protein according to claim 6, wherein said repeating unit is selected from.the group consisting of SGAGAG (SEQ ID NO:21) and GAGAGS (SEQ ID NO:41).
Claim 12
Dependent Claim
32 words
The recombinantly produced protein according to claim 6, wherein said repeating unit is selected from the group consisting of GVGVP (SEQ ID NO:23), VPGVG (SEQ ID NO:24), and APGVGV (SEQ ID NO:25).
Claim 13
Dependent Claim
42 words
The recombinantly produced protein according to claim 6, wherein said repeating unit is Gαβ, wherein α and β are any amino acid, α and β being selected so that said recombinantly produced protein comprises from about 10 to 45 number % proline.
Claim 14
Dependent Claim
46 words
The recombinantly produced protein according to claim 6, wherein said repeating unit is K-L-(1)-L-A-E-A (SEQ ID NO:105), wherein 1 is a basic or acidic amino acid, particularly K or E, and the repeating units alternate as to whether 1 is a basic or acidic amino acid.
Claim 15
Dependent Claim
87 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein, further comprising an intervening group of from 1 to 50 amino acids in length between at least 2 repeating units.
Claim 16
Dependent Claim
87 words
A recombinantly produced protein of from 30 kDal to 250 kDal comprising at least 50 number percent of amino acids of at least one naturally occurring repeating unit of a naturally occurring structural protein, wherein said repeating unit is from 3 to 20 amino acids in length and repeating units having the same amino acid sequence are tandemly repeated at least once in said recombinantly produced protein, further comprising an intervening group of from 1 to 50 amino acids in length between at least 2 repeating units.
Claim 17
Dependent Claim
12 words
A formed object comprising the recombinantly produced protein according to claim 1.
Claim 18
Dependent Claim
12 words
A formed object comprising the recombinantly produced protein according to claim 6.
Claim 19
Dependent Claim
12 words
A formed object comprising the recombinantly produced protein according to claim 13.
References Cited (Backward Citations)
US4132746A
Cited
US4187852A
Cited
US4474851A
Cited
US4500700A
Cited
US4589882A
Cited
GB2162190A
Cited
US5149657A
Cited
US5089406A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-06-22 | 2001-12-22 | 2002-06-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-06-22 | 2005-12-22 | 2006-06-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-06-22 | 2009-12-22 | 2010-06-23 | $7700.00 | Window Closed / Lapsed |