US5681852A — Desquamation compositions

Claim 1

Independent Claim 178 words

A topical composition for desquamation in mammalian skin, comprising: a) desquamation actives comprising: (i) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR14## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds; and combinations thereof: and (ii) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically-and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 2

Dependent Claim 178 words

A topical composition for desquamation in mammalian skin, comprising: a) desquamation actives comprising: (i) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR14## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds; and combinations thereof: and (ii) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically-and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 3

Dependent Claim 30 words

The composition of claim 1 wherein the sulfhydryl compound is selected from the group consisting of N-acetyl-L-cysteine, glutathione, cosmetically-and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof.

Claim 4

Dependent Claim 18 words

The composition of claim 2 wherein the composition further comprises from about 0.1% to about 10% salicylic acid.

Claim 5

Dependent Claim 51 words

The composition of claim 2 wherein: (a) R 2 and R 3 are selected from the group consisting of CH 3 , CH 2 CH 2 OH and CH 2 CH 2 CH 2 OH; (b) X is CO 2 or SO 3 ; and (c) m is 2 or 3.

Claim 6

Dependent Claim 40 words

The composition of claim 4 wherein R 4 has from 1 to about 3 carbon atoms when X is CO 2 , and R 4 has from about 2 to about 4 carbon atoms when X is SO 3 .

Claim 7

Dependent Claim 12 words

The composition of claim 5 wherein the zwitterionic surfactant is behenyl betaine.

Claim 8

Dependent Claim 55 words

The composition of claim 5 wherein: a) R 1 has from about 11 to about 18 carbon atoms; b) R 2 and R 3 are CH 3 ; and c) R 4 has 1 carbon atom when X is CO 2 ; and R 4 has 3 carbon atoms when X is SO 3 .

Claim 9

Dependent Claim 28 words

The composition of claim 7 wherein: (a) R 4 has 3 carbon atoms; (b) X is SO 3 ; (c) m is 3; and (d) n is 1.

Claim 10

Dependent Claim 22 words

The composition of claim 7 wherein the sulfhydryl compound is N-acetyl-L-cysteine, a cosmetically- and/or pharmaceutically-acceptable salt of N-acetyl-L-cysteine, or a combination thereof.

Claim 11

Dependent Claim 17 words

The composition of claim 9 wherein the zwitterionic surfactant is cocoamidopropyl betaine or cetyl propyl hydroxy sultaine.

Claim 12

Dependent Claim 12 words

The composition of claim 9 wherein the zwitterionic surfactant is cetyl betaine.

Claim 13

Dependent Claim 12 words

The composition of claim 9 wherein the zwitterionic surfactant is stearyl betaine.

Claim 14

Dependent Claim 28 words

The composition of claim 7 wherein: (a) R 4 has 1 carbon atom; (b) X is CO 2 ; (c) m is 3; and (d) n is 1.

Claim 15

Dependent Claim 20 words

The topical composition of claim 1 wherein said desquamation actives consist essentially of said zwitterionic surfactant and said sulfhydryl compound.

Claim 16

Dependent Claim 171 words

A topical composition comprising: (a) from about 0.1% to about 10% of a zwitterionic surfactant having the structure: ##STR15## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds; and combinations thereof; (b) from about 0.1% to about 20% of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 17

Dependent Claim 171 words

A topical composition comprising: (a) from about 0.1% to about 10% of a zwitterionic surfactant having the structure: ##STR15## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds; and combinations thereof; (b) from about 0.1% to about 20% of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 18

Dependent Claim 28 words

The topical composition of claim 15 comprising from about 0.5% to about 5% of said sulfhydryl compound and from about 0.5% to about 2% of said zwitterionic surfactant.

Claim 19

Independent Claim 187 words

A method of achieving desquamation of mammalian skin comprising topically applying to a mammal in need of such treatment a composition comprising: a) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR16## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of, CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 20

Independent Claim 187 words

A method of achieving desquamation of mammalian skin comprising topically applying to a mammal in need of such treatment a composition comprising: a) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR16## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of, CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 21

Dependent Claim 77 words

The method of claim 17 wherein: (a) R 2 and R 3 are selected from the group consisting of CH 3 , CH 2 CH 2 OH and CH 2 CH 2 CH 2 OH; (b) X is CO 2 or SO 3 ; (c) m is 2 or 3; and (d) the sulfhydryl compound is selected from the group consisting of N-acetyl-L-cysteine, glutathione, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof.

Claim 22

Dependent Claim 47 words

The method of claim 18 wherein: (a) the amount of sulfhydryl compound applied is from about 0.004 mg/cm 2 skin to about 0.1 mg/cm 2 skin; and (b) the amount of zwitterionic surfactant applied is from about 0.004 mg/cm 2 skin to about 0.1 mg/cm 2 skin.

Claim 23

Dependent Claim 47 words

The method of claim 19 wherein: (a) the amount of sulfhydryl compound applied is from about 0.02 mg/cm 2 skin to about 0.06 mg/cm 2 skin; and (b) the amount of zwitterionic surfactant applied is from about 0.02 mg/cm 2 skin to about 0.06 mg/cm 2 skin.

Claim 24

Dependent Claim 31 words

The method of claim 20 wherein; (a) the zwitterionic surfactant is stearyl betaine; and (b) the sulfhydryl compound is N-acetyl-L-cysteine, a cosmetically- and/or pharmaceutically-acceptable salt of N-acetyl-L-cysteine, or a combination thereof.

Claim 25

Dependent Claim 31 words

The method of claim 20 wherein; (a) the zwitterionic surfactant is cetyl betaine; and (b) the sulfhydryl compound is N-acetyl-L-cysteine, a cosmetically- and/or pharmaceutically-acceptable salt of N-acetyl-L-cysteine, or a combination thereof.

Claim 26

Independent Claim 189 words

A method of treating acne in mammalian skin comprising topically applying to a mammal susceptible to or suffering from ache a composition comprising: a) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR17## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 27

Independent Claim 189 words

A method of treating acne in mammalian skin comprising topically applying to a mammal susceptible to or suffering from ache a composition comprising: a) a safe and effective amount of a sulfhydryl compound selected from the group consisting of N-acetyl-L-cysteine, glutathione, dithiothreitol, dithioerythritol, homocysteine, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof; and b) a safe and effective amount of a zwitterionic surfactant having the structure: ##STR17## wherein R 1 is unsubstituted, saturated or unsaturated, straight or branched chain alkyl having from about 9 to about 22 carbon atoms; m is an integer from 1 to 3; n is 0 or 1; R 2 and R 3 are, independently, alkyl having from 1 to about 3 carbon atoms, unsubstituted or mono-substituted with hydroxy; R 4 is saturated or unsaturated, straight or branched chain alkyl, unsubstituted or mono-substituted with hydroxy, having from 1 to about 5 carbon atoms; and X is selected from the group consisting of CO 2 , SO 3 and SO 4 ; cosmetically- and/or pharmaceutically-acceptable salts of the foregoing compounds, and combinations thereof; and (c) a cosmetically- and/or pharmaceutically-acceptable topical carrier.

Claim 28

Dependent Claim 77 words

The method of claim 23 wherein: (a) R 2 and R 3 are selected from the group consisting of CH 3 , CH 2 CH 2 OH and CH 2 CH 2 CH 2 OH; (b) X is CO 2 or SO 3 ; (c) m is 2 or 3; and (d) the sulfhydryl compound is selected from the group consisting of N-acetyl-L-cysteine, glutathione, cosmetically- and/or pharmaceutically-acceptable salts of any of the foregoing compounds, and combinations thereof.

Claim 29

Dependent Claim 47 words

The method of claim 24 wherein: (a) the amount of sulfhydryl compound applied is from about 0.004 mg/cm 2 skin to about 0.1 mg/cm 2 skin; and (b) the amount of zwitterionic surfactant applied is from about 0.004 mg/cm 2 skin to about 0.1 mg/cm 2 skin.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	2000-10-27	2001-04-28	2001-10-28	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2004-10-27	2005-04-28	2005-10-28	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2008-10-27	2009-04-28	2009-10-28	$7700.00	Window Closed / Lapsed

Desquamation compositions

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