US5658332A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioactive granules for bone tissue formation
Assignee: Biomet 3I LLC
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Filing: 1994-06-30
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Granted: 1997-08-19
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Expires: 2014-06-30
Abstract
Abstract Methods for forming osseous tissue in defects in sites in the appendicular skeleton or sites exhibiting reduced metabolic state using bioactive glass granules containing 40 to 58% SiO2, 10 to 30% NaO, 10 to 30% CaO, and 0 to 10% P2O5, and in the size range of from 200 to 300 micrometers, are described.
Inventors
- 👤 Paul Ducheyne
- 👤 D. Scott Metsger
- 👤 Evert Schepers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:49
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/025; A61F; A61F2/00; A61F2/02; A61F2/28
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
123 words
A method for forming osseous tissue throughout an orthopaedic defect in a site located in the appendicular skeleton comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O, from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
Claim 2
Independent Claim
123 words
A method for forming osseous tissue throughout an orthopaedic defect in a site located in the appendicular skeleton comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O, from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
Claim 3
Dependent Claim
50 words
The method of claim 1 wherein said particles consist essentially of: from about 42 to about 54% SiO 2 , from about 15 to about 27% Na 2 O, from about 15 to about 27% CaO and from about 3 to about 8% P 2 O 5 , by weight.
Claim 4
Dependent Claim
34 words
The method of claim 1 wherein said particles consist essentially of about 45% SiO 2 , about 24.5% Na 2 O, about 24.5% CaO, and about 6% P 2 O 5 , by weight.
Claim 5
Dependent Claim
34 words
The method of claim 1 wherein said particles consist essentially of about 52% SiO 2 , about 21% Na 2 O, about 21% CaO, and about 6% P 2 O 5 , by weight.
Claim 6
Independent Claim
122 words
A method for forming osseous tissue throughout an osseous defect in a site of reduced metabolic state comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O, from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
Claim 7
Independent Claim
122 words
A method for forming osseous tissue throughout an osseous defect in a site of reduced metabolic state comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O, from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
Claim 8
Dependent Claim
50 words
The method of claim 5 wherein said particles consist essentially of: from about 42 to about 54% SiO 2 , from about 15 to about 27% Na 2 O, from about 15 to about 27% CaO and from about 3 to about 8% P 2 O 5 , by weight.
Claim 9
Dependent Claim
34 words
The method of claim 5 wherein said particles consist essentially of about 45% SiO 2 , about 24.5% Na 2 O, about 24.5% CaO, and about 6% P 2 O 5 , by weight.
Claim 10
Dependent Claim
33 words
The method of claim 5 wherein said particles consist essentially of 52% SiO 2 , about 21% Na 2 O, about 21% CaO, and about 6% P 2 O 5 , by weight.
Claim 11
Independent Claim
126 words
A method for forming osseous tissue throughout an osseous defect in a site of reduced metabolic state in an osteoporotic subject comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
Claim 12
Independent Claim
126 words
A method for forming osseous tissue throughout an osseous defect in a site of reduced metabolic state in an osteoporotic subject comprising a) filling said site with particles consisting essentially of: from about 40 to about 58% SiO 2 , from about 10 to about 30% Na 2 O from about 10 to about 30% CaO and up to about 10% P 2 O 5 , by weight in a size range of from about 200 to about 300 micrometers; and b) whereby said particles are to be transformed, and individual particles become excavated, forming a calcium phosphate outer layer with a central cavity into which osteoprogenitor cells penetrate and differentiate into bone forming cells which, in association with osteoconduction, results in said osseous tissue formation.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-18 | 2001-02-17 | 2001-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-18 | 2005-02-17 | 2005-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-18 | 2009-02-17 | 2009-08-19 | $7700.00 | Window Closed / Lapsed |