US5204106A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for restoring an osseous defect or deficiency by filling with osseous tissue
Assignee: Biomet 3I LLC
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Filing: 1990-04-19
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Granted: 1993-04-20
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Expires: 2010-04-19
Abstract
Abstract Process for the restoration of an osseous defect or deficiency by filling with osseous tissue with the aid of a bioreactive granular material causing an osteostimulation, the particles of said granular material being disintegrated from the inside, dissolved and replaced by osseous tissue, the granular material containing 40 to 55% SiO2, 10 to 32% Na2O, 0 to 12% P2O5 and 10 to 32% CaO, which has a grain size distribution between 280 and 425 mu m, sharp edges, an irregular profile and surface microdefects or microcracks.
Inventors
- 👤 Evert Schepers
- 👤 Paul Ducheyne
- 👤 Raymond Kempeneers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:59
CPC Classifications
C; C03; C03C; C03C4/00; C03C4/0007; A; A61; A61L; A61L27/00; A61L27/02; A61L27/10; A61L27/12; C03C3/00; C03C3/04; C03C3/076; C03C3/097; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
142 words
Process for the formation of osseous tissue for filling an osseous defect or deficiency, comprising introducing particles consisting essentially of an inorganic, non-fluorinated, bioreactive granular material having sharp edges, an irregular profile and surface defects or microcracks into said osseous defect or deficiency in order to cause osteogenesis by osteostimulation, said particles being progressively dissolved internally, by way of said surface defects or microcracks to create a central cavity in which mesenchymal precursor cells are differentiated into osteoblasts, followed by progressive replacement of said particles by osseous tissue, said particles consisting essentially of, by weight: SiO 2 between 40 and 55%; Na 2 O between 10 and 32%; P 2 O 5 between 0 and 12%; and CaO between 10 and 32%; and having a grain size distribution such that at least 95% of the particles are between 280 and 425 μm.
Claim 2
Dependent Claim
142 words
Process for the formation of osseous tissue for filling an osseous defect or deficiency, comprising introducing particles consisting essentially of an inorganic, non-fluorinated, bioreactive granular material having sharp edges, an irregular profile and surface defects or microcracks into said osseous defect or deficiency in order to cause osteogenesis by osteostimulation, said particles being progressively dissolved internally, by way of said surface defects or microcracks to create a central cavity in which mesenchymal precursor cells are differentiated into osteoblasts, followed by progressive replacement of said particles by osseous tissue, said particles consisting essentially of, by weight: SiO 2 between 40 and 55%; Na 2 O between 10 and 32%; P 2 O 5 between 0 and 12%; and CaO between 10 and 32%; and having a grain size distribution such that at least 95% of the particles are between 280 and 425 μm.
Claim 3
Dependent Claim
16 words
Process according to claim 1, wherein 2/3 of the particles are between 300 and 360 μm.
Claim 4
Dependent Claim
18 words
Process according to claim 2, wherein at least 90% of the particles are between 300 and 360 μm.
Claim 5
Dependent Claim
47 words
Process according to claim 2 or 3, wherein the particles consist essentially of bioreactive glass having a composition, by weight: SiO 2 between 42 and 48%; Na 2 O between 14 and 28%; P 2 O 5 between 0 and 10%; and CaO between 20 and 29%.
Claim 6
Dependent Claim
51 words
Process according to claim 1, 2 or 3, comprising forming said particles by melting together a mixture of inorganic powders containing the constituents of said particles, molding said melted powders and solidifying in the absence of contact with any material reactive with said mixture of powders, and pulverizing said solidified mixture.
Claim 7
Dependent Claim
48 words
Process according to claim 4, comprising forming said particles by melting together a mixture of inorganic powders containing the constituents of said particles, molding said melted powders and solidifying in the absence of contact with any material reactive with said mixture of powders, and pulverizing said solidified mixture.
Claim 8
Dependent Claim
13 words
Process according to claim 5, wherein said pulverizing takes place with a hammer.
Claim 9
Dependent Claim
13 words
Process according to claim 6 wherein said pulverizing takes place with a hammer.
References Cited (Backward Citations)
US3981736A
Cited
US3905047A
Cited
DE3306648A1
Cited
EP0112319A1
Cited
US4563350A
Cited
JPS63242263A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-04-19 | 1996-10-19 | 1997-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-04-19 | 2000-10-19 | 2001-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-04-19 | 2004-10-19 | 2005-04-20 | $7700.00 | Window Closed / Lapsed |