US5655546A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for cartilage repair
Assignee: Individual
•
Filing: 1995-06-07
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Granted: 1997-08-12
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Expires: 2015-06-07
Abstract
Abstract A method for repairing a defect in cartilage, comprising the provision of apertures in the cartilage by drilling holes at the base of the cartilage defect, which holes may enter the mesenchymal depot, introducing a porous scaffold material containing a plurality of magnetic particles into the apertures, and subsequently and sequentially injecting magnetically-tagged cartilage growth promoting materials such as various growth factors or chondrocytes into the area of the defect. The magnetically tagged growth promoting material is then drawn into the apertures by magnetic attraction of the magnetic particles contained in the porous scaffold material, either by virtue of the particles being permanently magnetic, or by the imposition of an external magnetic field. The present application claims the biodegradable porous scaffold material containing the plurality of magnetic particles.
Inventors
- 👤 Alan A. Halpern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3804; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30756; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5094; A61L27/14; A61L27/18; A61L27/22; A61L27/227; A61L27/3839; A61L27/3843; A61L27/3852; A61L27/50; A61L27/56; A61L27/58; A61F2/28; A61F2002/2817; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30079; A61F2002/30667; A61F2002/30677; A61F2002/30766; A61F2210/00; A61F2210/0004; A61F2210/009; A61L2430/00; A61L2430/06; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/92
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
87 words
A method for repairing a defect in cartilage, comprising: locating a cartilage defect and defining a subchondral base in the cartilage defect, providing apertures in said cartilage at the base of the cartilage defect, introducing a porous scaffold material containing a plurality of magnetic particles into said apertures, and injecting magnetically-tagged cartilage growth promoting material in the area of said cartilage defect, whereby said magnetically-tagged cartilage growth promoting material is drawn into said apertures by magnetic attraction of the magnetic particles contained in said porous scaffold material.
Claim 2
Independent Claim
87 words
A method for repairing a defect in cartilage, comprising: locating a cartilage defect and defining a subchondral base in the cartilage defect, providing apertures in said cartilage at the base of the cartilage defect, introducing a porous scaffold material containing a plurality of magnetic particles into said apertures, and injecting magnetically-tagged cartilage growth promoting material in the area of said cartilage defect, whereby said magnetically-tagged cartilage growth promoting material is drawn into said apertures by magnetic attraction of the magnetic particles contained in said porous scaffold material.
Claim 3
Dependent Claim
73 words
A method according to claim 1, wherein an external magnetic field is applied to the area of said cartilage defect while said magnetically-tagged cartilage growth promoting material is injected in the area of said cartilage defect, thereby increasing the magnetic force exhibited by the magnetic particles contained in said porous scaffold material, and thereby facilitating the introduction of said magnetically-tagged cartilage growth promoting material into the apertures provided in said cartilage defect area.
Claim 4
Dependent Claim
18 words
A method according to claim 1, wherein the magnetic particles contained in said scaffold material are permanently magnetized.
Claim 5
Dependent Claim
22 words
A method according to claim 1, wherein the magnetic particles to which said cartilage growth promoting material is magnetically-tagged are permanently magnetized.
Claim 6
Dependent Claim
27 words
A method according to claim 1, wherein said magnetically-tagged cartilage growth promoting material is selected from the group consisting of growth factors and chondrocytes and endothelial cells.
Claim 7
Dependent Claim
46 words
A method according to claim 5, wherein said growth factors are selected from the group consisting of cartilage-derived growth factors (CDGF), transforming growth factor Beta (TGF-beta), connective tissue activating peptides (CTAP), insulin-like growth factor (IGF-1), acidic fibroblast growth factor (aFGF), and basic fibroblast growth factor (bFGF).
Claim 8
Dependent Claim
17 words
A method according to claim 5, wherein said cartilage growth promoting material is chondrocytes or endothelial cells.
Claim 9
Dependent Claim
15 words
A method according to claim 1, wherein said apertures are provided through the subchondral base.
Claim 10
Dependent Claim
22 words
A method according to claim 1, wherein said apertures are provided through both said subchondral base and into a mesenchymal cell depot.
Claim 11
Dependent Claim
25 words
A method according to claim 1, wherein said scaffold material is selected from the group consisting of collagen, biodegradable polymers, polyglycolic acid, and carbon fibers.
Claim 12
Dependent Claim
13 words
A method according to claim 1 wherein said porous scaffold material is collagen.
Claim 13
Dependent Claim
15 words
A method according to claim 1 wherein said porous scaffold material is a biodegradable polymer.
Claim 14
Dependent Claim
22 words
A method according to claim 12 wherein said polymer contains a mixture of polylactic acid and polyglycolic acid combined with magnetic particles.
Claim 15
Dependent Claim
37 words
A method according to claim 12 wherein said biodegradable polymer has a pore size of 50 to 400 microns sized to contain particles selected from the group consisting of magnetic particles, mesenchymal cells, stem cells, and chondrocytes.
Claim 16
Dependent Claim
23 words
A method according to claim 12 wherein said biodegradable polymer is implanted with ferrous particles having a size of 0.05 to 500 microns.
Claim 17
Dependent Claim
34 words
A method according to claim 1 wherein said growth factors are tagged with magnetic particles which are then injected into the joint to stimulate chondrogenesis and the formation of cartilage in a cartilage defect.
Claim 18
Dependent Claim
39 words
A method according to claim 1 wherein stem or mesenchymal cells are extracted from the marrow of the bone underlying the cartilage defect and implanted in the porous scaffold material for the purpose of cartilage formation in the defect.
Claim 19
Dependent Claim
24 words
A method according to claim 1 wherein said magnetically-tagged growth promoting factors are selected from the group consisting of dFGF, IGF, TGF-BETA, and BMP.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-08-11 | 2001-02-10 | 2001-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-08-11 | 2005-02-10 | 2005-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-08-11 | 2009-02-10 | 2009-08-12 | $7700.00 | Window Closed / Lapsed |