US4758429A — Method for the treatment of arthritis and inflamm…

Claim 1

Independent Claim 120 words

A process for the treatment of arthritis and other non-infections joint diseases by affecting particles present and/or introduced intracellularly into reactive and/or inflammatory diseased cells in the joint and joint space without substantially damaging normal cells, providing to said host joint minute particles capable of being taken up by said reactive and/or inflammatory diseased joint cells, allowing said particles to effect at least one event comprising intracellular events and membrane events in said reactive and/or inflammatory diseased cells in the joint space and area, subjecting said joint space and area to a relatively low frequency alternating, oscillating and/or pulsed electromagnetic field to provide energy to reactive and/or inflammatory diseased cells and selectively heat said reactive and/or inflammatory diseased joint cells.

Claim 2

Dependent Claim 120 words

A process for the treatment of arthritis and other non-infections joint diseases by affecting particles present and/or introduced intracellularly into reactive and/or inflammatory diseased cells in the joint and joint space without substantially damaging normal cells, providing to said host joint minute particles capable of being taken up by said reactive and/or inflammatory diseased joint cells, allowing said particles to effect at least one event comprising intracellular events and membrane events in said reactive and/or inflammatory diseased cells in the joint space and area, subjecting said joint space and area to a relatively low frequency alternating, oscillating and/or pulsed electromagnetic field to provide energy to reactive and/or inflammatory diseased cells and selectively heat said reactive and/or inflammatory diseased joint cells.

Claim 3

Dependent Claim 38 words

The process of claim 1 including the utilization of magnetic or electric dipoles present or capable of being induced in the joint or in the reactive and/or inflammatory diseased cells of the joint or in the joint space.

Claim 4

Dependent Claim 15 words

The process of claims 1 or 2 wherein particles are introduced intravenously, intra-arterially, or intra-lymphatically.

Claim 5

Dependent Claim 18 words

The process of claims 1 or 2 wherein particles are introduced directly into the joint and/or joint space.

Claim 6

Dependent Claim 14 words

The process of claims 1 or 2 wherein particles are ferromagnetic, paramagnetic or diamagnetic.

Claim 7

Dependent Claim 18 words

The process of claims 1 or 2 wherein particles are colloidally suspended and under one micron in size.

Claim 8

Dependent Claim 39 words

The process of claims 1 or 2 wherein said particles are selected from the group consisting of ferromagnetic, paramagnetic and diamagnetic elements, inorganic compounds, organic compounds and combinations thereof metalloporphyrins, Fe 2 O 3 , FeOOH, and metal metalloporphyrins.

Claim 9

Dependent Claim 104 words

The process of claim 7 wherein said particles are selected from the group consisting of (a) cobalt, zinc, iron, chromium, nickel, platinum, rare earth metals consisting of dysprosium, erbium, europium, gadolinium, holmium, samarium, terbium, thulium, ytterbium, yttrium and compounds thereof consisting of dysprosium sulfate, erbium sulfate, europium oxide, europium sulfate, gadolinium oxide, gadolinium sulfate, holmium oxide, samarium sulfate, terbium sulfate, thulium oxide, ytterbium sulfide, yttrium oxide, yttrium sulfate, yttrium ferrioxide (Y 3 Fe 5 O 12 ), yttrium oxide (Y 3 Al 5 O 12 ), dysprosium-nickel, ysprosium cobalt, gadolinium-iron, ytterbium-iron, cobalt-samarium, gadolinium-ytterbium, dysprosium-gallium, and actinide series elements and compounds thereof; and combinations thereof.

Claim 10

Dependent Claim 150 words

The process of claim 7 wherein said organic compounds are selected from the group consisting of; (a) dextran metal complexes wherein said metal is selected from the group consisting of cobalt, zinc, chromium, iron, gallium, manganese, nickel, platinum, dysprosium, erbium, europium, gadolinium, holmium, samarium, terbium, thulium, ytterbium, yttrium, dysprosium-nickel, dysprosium-cobalt, gadolinium-iron, ytterbium-iron, cobalt-samarium, gadolinium-yttrium, and dysprosium-gallium, and iron consisting of Fe 2 O 3 particles, Fe 3 O 4 particles and FeOOH particles and Fe 2 O 3 -dextran complexes, Fe 3 O 4 -dextran complexes, and FeOOH-dextran complexes; (b) iron transporting and chelating compounds consisting of ferric ammonium citrate, enterochelin, transferrin, metallothionein, hydroxamates, phenolates, ferrichromes, desferriferrichromes, ferritin, ferric mycobactins and iron sulfur proteins consisting of ferredoxin and rubredoxin; (c) porphyrins comprising etioporphyrins, meso-porphyrins, uroporphyrins, coproporphyrins, protoporphyrins, dicarboxylic acid containing porphyrins, substituted porphyrins consisting of tetraphenylporphyrin sulfonate and protoporphyrin containing molecules consisting of hematoporphyrins, chlorophylls, and cytochromes; and combinations thereof.

Claim 11

Dependent Claim 57 words

The process of claim 9 wherein said prophyrin is one in which the natural occurring metal moiety is substituted with a metal selected from the group consisting of cobalt, zinc, chromium, gallium, iron, manganese, nickel, platinum, dysprosium, erbium, europium, gadolinium, holmium, samarium, terbium, thulium, ytterbium, yttrium, dysprosium-nickel, dysprosium-cobalt, gadolinium-iron, yttrebium-iron, cobalt-samarium, gadolinium-yttrium, and dysprosium-gallium; and combinations thereof.

Claim 12

Dependent Claim 22 words

The process according to claims 9 or 10 wherein said iron transporting, iron chelating and porphyrin compounds are chemically complexed with dextran.

Claim 13

Dependent Claim 15 words

The process according to claim 11 wherein said composition is chemically complexed with an antibody.

Claim 14

Dependent Claim 165 words

The process according to claim 9 wherein the metal-organic compound complexes are selected from the group consisting of Fe(III) Tetraphenylporphyrin sulfonate (TPPS 4 ) Acetate, Fe(III) TPPS 4 Acetate 4Na Salt (H 2 O), Fe(III) Mesoporphyrin IX Chloride, Fe(III) TPPS 4 Chloride, Co TPPS 4 , Co(III) MesoTPPS 4 Tetra Na Salt (Acetate), Fe Phthalocyanine Tetrasulfonate Tetra sodium salt, Tetra Sodium-meso-Tetra (4-sulfonate-phenyl) Porphine (12 hydrate), Fe(III) Tetra (N-Methyl 4-Puridyl) Porphyrin Pentachloride, Fe Phthalocyanine, Hemin, Fe-Hematoporphyrin D (HPD), Fe-Acetoxyethyl vinyl Deuteroporphyrin, Fe-Protoporphyrin IX, Fe-Deuteroporphyrin 2, 4 bis acetal, Mn-TPPS 4 , Co-N + MTPyP, Mn-N + MTPyP, Co-Mesoporphyrin X, Protohemin, Deuterohemin, Meso-tetra (4-N methyl pyridyl) hemin tetraiodide, Meso-tetra (4-carboxy phenyl) hemin, Ni-TPPS, Ni-HPD, Mn-mesoporphyrin IX, Co-Protoporphyrin IX, Mn-Protoporphyrin IX, Sn-Protoporphyrin IX, Co-HPD, Mn-HPD, Gd-TPPS, Gd-HPD, Hematoporphyrin Mono-acetate-Fe, Ferretin-Fe, Ferredoxin-Fe(4), Transferrin-Fe, Hematoporphyrin Diacetate-Gd, GdFe-TPPS 4 , GdFe 2 -HPD, FeTPPS 4 (OH 2 ) 2 ClO 4 -, FeTPP (OH 2 ) 2 ClO 4 -, Fe-Nitrolacetate, Fetetrasulfinated phalocyanine, Bisimidozole (FeTPPS)ClO 4 -, Rubrium-ferricytochrome/C, and combinations thereof.

Claim 15

Dependent Claim 16 words

The process according to claim 13 wherein said metal-organic compound complexes are chemically complexed with dextran.

Claim 16

Dependent Claim 15 words

The process according to claim 14 wherein said composition is chemically complexed with an antibody.

Claim 17

Dependent Claim 59 words

A process for affecting molecules in the joint cell and subcellular structures in the tissue of a host organism comprising applying a constant magnetic field to said tissue to affect the relative dipole moment and producing direct effects on subcellular structures and molecules in the cells of said tissue by introducing particles into the living cells of said tissue.

Claim 18

Dependent Claim 59 words

A process for affecting molecules in the joint cell and subcellular structures in the tissue of a host organism comprising applying a constant magnetic field to said tissue to affect the relative dipole moment and producing direct effects on subcellular structures and molecules in the cells of said tissue by introducing particles into the living cells of said tissue.

Claim 19

Dependent Claim 25 words

The process of claim 16 wherein the constant magnetic field is initially utilized and thereafter applying an alternating electromagnetic field to achieve an enhanced effect.

Claim 20

Dependent Claim 26 words

A process for the diagnosis of non-infectious joint disease through the use of intra-articular particles which may be intracellular in the cells contained in the joint.

Claim 21

Dependent Claim 26 words

A process for the diagnosis of non-infectious joint disease through the use of intra-articular particles which may be intracellular in the cells contained in the joint.

Claim 22

Dependent Claim 22 words

The process of claim 1 wherein magnetic susceptibility measurements are performed to diagnose the involved joints by the uptake of the particles.

Claim 23

Dependent Claim 16 words

The process of claim 1 wherein magnetic mapping measurements are performed to diagnose the involved joints.

Claim 24

Dependent Claim 18 words

The process of claim 20 wherein magnetic susceptibility measurements are performed to determine the optimum time of treatment.

Claim 25

Dependent Claim 26 words

The process of claim 19 wherein magnetic susceptibility and magnetic mapping measurements are performed to help diagnose the type of disease process present in the joint.

Claim 26

Dependent Claim 42 words

The process of claim 1 or 2 comprising applying a localized static magnetic or electric field to joint tissue to aid in the intracellular uptake and energy absorption of the electric or magnetic dipoles either introduced or already present in said joint.

Claim 27

Dependent Claim 55 words

The process of claims 1 and 2 wherein a localized static magnetic or electric field is applied to said joint after providing said particles but prior to or during the application of said alternating, oscillating and/or pulsed electromagnetic field to enhance the intracellular uptake of energy and the energy-absorption responsiveness of said particles in joint.

Claim 28

Dependent Claim 55 words

The process of claim 17 wherein a localized static magnetic or electric field is applied to the joint prior to and/or during the application of said alternating, oscillating and/or pulsed electromagnetic field to enhance the intracellular energy uptake and energy absorption of the electric or magnetic dipoles either introduced or already present in the joint.

Claim 29

Dependent Claim 41 words

The process of claims 1 or 2 wherein a constant magnetic field through interaction with intracellular dipoles in the joint is utilized to modify the behavior of the reactive and/or inflammatory diseased cells of the joint to slow the degenerative process.

Claim 30

Dependent Claim 19 words

The process of claim 16 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 31

Dependent Claim 23 words

The process of claims 1 or 2 wherein said alternating, oscillating and/or pulsed electromagnetic field is between 1 Hz to about 100 MHz.

Claim 32

Dependent Claim 48 words

The process of claims 1 or 2 including an external alternating electromagnetic field applied to excite the particles and raise the energy level in the reactive and/or inflammatory diseased cells of the joint to destroy said joint cells or modify their behavior to decrease the joint degenerative process.

Claim 33

Dependent Claim 40 words

The process of claims 1 or 2 wherein the treatment is continued to attain an increase of intracellular temperature of between 8 Centigrade and 100 Centigrade to modify, alter, and/or kill the reactive and/or inflammatory diseased cells of the joint.

Claim 34

Dependent Claim 44 words

The process of claims 1 or 2 wherein particles are introduced into the extracellular environment of said joint tissue to alter membrane events and potentiate energy delivery to said diseased inflammatory and/or reactive joint cells and/or reduce energy delivery to said normal joint cells.

Claim 35

Dependent Claim 29 words

The process of claims 1 or 2 wherein particles are introduced intravenously, intra-arterially, intra-lymphatically, and/or locally, for ultimate delivery to the reactive and/or inflammatory diseased cells of the joint.

Claim 36

Dependent Claim 35 words

The process for measurement of temperature in living tissue and cells in the joint comprising measuring the alteration in dielectric properties, conductivity and frequency dependent dispersion curves in living joint tissue and cells with temperature.

Claim 37

Dependent Claim 35 words

The process for measurement of temperature in living tissue and cells in the joint comprising measuring the alteration in dielectric properties, conductivity and frequency dependent dispersion curves in living joint tissue and cells with temperature.

Claim 38

Dependent Claim 32 words

The process of claim 33 comprising measuring said temperature along three axes at right angles in a host joint organism and producing a three-dimensional temperature map of the body from said measurements.

Claim 39

Dependent Claim 33 words

A process to measure the change in metabolism in living joint cells comprising measuring the alteration in dielectric properties of said joint cells and correlating said measurements with metabolism in said joint cells.

Claim 40

Dependent Claim 33 words

A process to measure the change in metabolism in living joint cells comprising measuring the alteration in dielectric properties of said joint cells and correlating said measurements with metabolism in said joint cells.

Claim 41

Dependent Claim 45 words

A process to follow the exact distribution of particles in living joint tissue and cells comprising measuring the alteration in dielectric properties, conductivity and frequency dependent dispersion curves of said tissue and joint cells with the introduction of particles into said tissue and joint cells.

Claim 42

Dependent Claim 45 words

A process to follow the exact distribution of particles in living joint tissue and cells comprising measuring the alteration in dielectric properties, conductivity and frequency dependent dispersion curves of said tissue and joint cells with the introduction of particles into said tissue and joint cells.

Claim 43

Dependent Claim 35 words

A process of claims 1 or 2 for affecting intracellular and extracellular events comprising subjecting said particles to ultrasound, said particles being selected to enhance the effect of ultrasound on said joint tissue and cells.

Claim 44

Dependent Claim 34 words

A process of claim 7 for affecting intracellular and extracellular events comprising subjecting said particles to ultrasound, said particles being selected to enhance the effect of ultrasound on said joint tissue and joint cells.

Claim 45

Dependent Claim 50 words

The process of claims 1 or 2 wherein an alternating electromagnetic field between 1 Hz and 500 MHz is used to affect said particles and make them more or less responsive to an exciting alternating electromagnetic field produced by magnetostrictive induced vibrations applied to said joint tissues and joint cells.

Claim 46

Dependent Claim 50 words

The process of claim 7 wherein said particles are selected to include compositions that specifically affect intracellular and extracellular events in said joint tissues and tissue cells or said particles are affected to make them more or less responsive to an exciting alternating electromagnetic field produced by magnetostrictive induced vibrations.

Claim 47

Dependent Claim 38 words

The process of claims 1 or 2 wherein an alternating electromagnetic field is applied to said particles to produce acoustic changes in said particles and affect the cellular and subcellular structures of said joint tissues and/or joint cells.

Claim 48

Dependent Claim 41 words

The process of claim 7 wherein said particles are selected to acoustically affect intracellular and extracellular events in said joint tissues and joint cells or said particle and affecting the cellular and subcellular structures of said joint tissues and joint cells.

Claim 49

Dependent Claim 24 words

The process of claims 1 or 2 wherein magnetic susceptibility measurements are performed to diagnose the involved joints by the uptake of the particles.

Claim 50

Dependent Claim 18 words

The process of claims 1 or 2 wherein magnetic mapping measurements are performed to diagnose the involved joints.

Claim 51

Dependent Claim 18 words

The process of claim 44 wherein magnetic susceptibility measurements are performed to determine the optimum time of treatment.

Claim 52

Dependent Claim 26 words

The process of claim 43 wherein magnetic susceptibility and magnetic mapping measurements are performed to help diagnose the type of disease process present in the joint.

Claim 53

Dependent Claim 26 words

The process of claim 44 wherein magnetic susceptibility and magnetic mapping measurements are performed to help diagnose the type of disease process present in the joint.

Claim 54

Dependent Claim 55 words

The process of claim 17 wherein a localized static magnetic or electric field is applied to the joint prior to and/or during the application of said alternating, oscillating and/or pulsed electromagnetic field to enhance the intracellular energy uptake and energy absorption of the electric or magnetic dipoles either introduced or already present in the joint.

Claim 55

Dependent Claim 55 words

The process of claim 23 wherein a localized static magnetic or electric field is applied to the joint prior to and/or during the application of said alternating, oscillating and/or pulsed electromagnetic field to enhance the intracellular energy uptake and energy absorption of the electric or magnetic dipoles either introduced or already present in the joint.

Claim 56

Dependent Claim 19 words

The process of claim 16 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 57

Dependent Claim 19 words

The process of claim 17 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 58

Dependent Claim 19 words

The process of claim 23 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 59

Dependent Claim 19 words

The process of claim 24 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 60

Dependent Claim 19 words

The process of claim 25 wherein the static magnetic or electric field is between 100 gauss and 80 kilogauss.

Claim 61

Dependent Claim 86 words

A process for the treatment of arthritis and non-infections joint diseases comprising: introducing into the joint or joint space minute particles capable of being taken up by the reactive and/or inflammatory diseased joint cells and of responding to a relatively low frequency electromagnetic field, and after said introducing, subjecting the joint or joint space to a relatively low frequency electromagnetic field having a frequency of less than 500 megahertz to energize and selectively heat said reactive and/or inflammatory diseased cells without substantially damaging the normal cells.

Claim 62

Dependent Claim 86 words

A process for the treatment of arthritis and non-infections joint diseases comprising: introducing into the joint or joint space minute particles capable of being taken up by the reactive and/or inflammatory diseased joint cells and of responding to a relatively low frequency electromagnetic field, and after said introducing, subjecting the joint or joint space to a relatively low frequency electromagnetic field having a frequency of less than 500 megahertz to energize and selectively heat said reactive and/or inflammatory diseased cells without substantially damaging the normal cells.

Claim 63

Dependent Claim 26 words

The process of claim 50 including, said subjecting including said frequency being selected to enhance the dielectric properties, conductivity and electric dipoles of the joint cells.

Claim 64

Dependent Claim 20 words

The process of claim 50 including, said subjecting including said field having a frequency between 1 hertz and 100 megahertz.

Claim 65

Dependent Claim 16 words

The process of claim 50 including, said subjecting including using capacitor plates to generate said field.

Claim 66

Dependent Claim 17 words

The process of claim 50 including, said subjecting including using a coil arrangement to generate said field.

Claim 67

Dependent Claim 15 words

The process of claim 50 including, said subjecting including using electrodes to generate said field.

Claim 68

Dependent Claim 16 words

The process of claim 50 including, said subjecting including said field being an alternating electromagnetic field.

Claim 69

Dependent Claim 16 words

The process of claim 50 including, said subjecting including said field being an oscillating electromagnetic field.

Claim 70

Dependent Claim 16 words

The process of claim 50 including, said subjecting including said field being a pulsing electromagnetic field.

Claim 71

Dependent Claim 31 words

The process of claim 50 including, before said subjecting, allowing said particles to effect at least one event comprising intracellular events and membrane events in said reactive or inflammatory diseased cells.

Claim 72

Dependent Claim 14 words

The process of claim 50 including, said introducing including said particles being introduced intravenously.

Claim 73

Dependent Claim 14 words

The process of claim 50 including, said introducing including said particles being introduced intra-arterially.

Claim 74

Dependent Claim 21 words

The process of claim 50 including, said introducing including said particles being less than one micron in size and colloidally suspended.

Claim 75

Dependent Claim 29 words

The process of claim 50 including, said introducing including said particles being absorbed into the joint cell and altering the intracellular environment and the charge accumulation on the membrane.

Claim 76

Dependent Claim 16 words

The process of claim 50 including, said introducing including said particles being ferromagnetic, paramagnetic, or diamagnetic.

Claim 77

Dependent Claim 20 words

The process of claim 50 including, said introducing including said particles being introduced directly into the joint and/or joint space.

Claim 78

Dependent Claim 20 words

The process of claim 50 including, said introducing including introducing said particles into the extracellular environment of the joint tissue.

Claim 79

Dependent Claim 30 words

The process of claim 50 including, after said introducing and before said subjecting, evaluating which joints are affected by the disease process by analyzing which joint takes up said particles.

Claim 80

Dependent Claim 13 words

The process of claim 73 including, said analyzing including using magnetic susceptibility measurements.

Claim 81

Dependent Claim 16 words

The process of claim 50 including, imparting a dipole to said particles before said subjecting step.

Claim 82

Dependent Claim 18 words

The process of claim 50 including, applying a constant magnetic field to the joint before said subjecting step.

Claim 83

Dependent Claim 16 words

The process of claim 75 including, said subjecting including said field being an alternating electromagnetic field.

Claim 84

Dependent Claim 19 words

The process of claim 50 including, performing magnetic susceptibility measurements to determine the optimum time of said subjecting step.

Claim 85

Dependent Claim 25 words

The process of claim 50 including, performing magnetic susceptibility and magnetic mapping measurements to help diagnose the type of disease process present in the joint.

Claim 86

Dependent Claim 18 words

The process of claims 1, 16, 19, 36 or 55 wherein the particles are metal containing organic molecules.

Claim 87

Dependent Claim 18 words

The process of claims 1, 16, 19, 36 or 55 wherein the particles are iron containing organic molecules.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1991-07-19	1992-01-18	1992-07-19	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1995-07-19	1996-01-18	1996-07-19	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1999-07-19	2000-01-18	2000-07-19	$7700.00	Window Closed / Lapsed

Method for the treatment of arthritis and inflammatory joint diseases

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag