US5624463A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prosthetic articular cartilage
Assignee: Regen Biologics Inc
•
Filing: 1994-04-25
•
Granted: 1997-04-29
•
Expires: 2014-04-25
Abstract
Abstract A prosthetic, resorbable articular cartilage and methods of its fabrication and insertion are disclosed. The prosthetic articular cartilage, when implanted in a humanoid joint, acts as a resorbable scaffold for ingrowth of native articular chondrocytes and supports natural articulating joint forces. The prosthetic articular cartilage is a dry, porous, volume matrix of biocompatible and bioresorbable fibers. These fibers include a natural polymer or analogs thereof, at least a portion of which may be crosslinked. The matrix is adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage in an articulating joint, and has a pore size in the approximate range of about 100 microns to about 400 microns.
Inventors
- 👤 Kevin R. Stone
- 👤 Shu-Tung Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:04
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/58; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/30756; A61F2/38; A61F2/3872; A61F2/44; A61F2/442; A61L27/14; A61L27/20; A61L27/22; A61L27/227; A61L27/24; A61L27/26; A61L27/40; A61L27/44; A61L27/46; A61L27/48; A61L27/56; C; C08; C08L; C08L1/00; A61F2/30767; A61F2/30907; A61F2/3094; A61F2/30965; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30006; A61F2002/3006; A61F2002/30062; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30131; A61F2002/30199; A61F2002/30205; A61F2002/30224; A61F2002/30225; A61F2002/3023; A61F2002/30667; A61F2002/30677; A61F2/30721; A61F2/30734; A61F2002/30736; A61F2002/30766; A61F2/30771; A61F2002/30795; A61F2002/30807; A61F2002/30808; A61F2002/3082; A61F2002/30822; A61F2002/30827; A61F2002/30878; A61F2002/30879; A61F2002/30881; A61F2002/30891; A61F2002/30904; A61F2/30942; A61F2002/30957; A61F2/42; A61F2/4261; A61F2002/4271; A61F2002/4274; A61F2002/4276; A61F2002/4279; A61F2002/4282; A61F2002/4284; A61F2002/4287; A61F2002/4289; A61F2002/4292; A61F2002/4294; A61F2002/4297; A61F2210/00; A61F2210/0004; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0013; A61F2230/0063; A61F2230/0067; A61F2230/0069; A61F2250/00; A61F2250/0014; A61F2250/0015; A61F2250/0057; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/06; A61L2430/38
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
164 words
A prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and at least bioresorbable fibers and further comprising a base component, said fibers being natural polymers or analogs or mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, and said matrix having a pore size in the approximate range of about 100 microns to about 400 microns, whereby said matrix establishes a bioresorbable scaffold adapted for the ingrowth of articular chondrocytes, and for supporting natural articulating joint forces, said base component configured to fit in a complementary aperture in cancellous bone thereby securing said articular cartilage device to said bone, said base component extending from portions of the outer surface of said matrix, said base component being a composite material comprising a dispersion of collagen and a composition which is selected from the group consisting of tricalcium phosphate, hydroxyapatite, and a combination of tricalcium phosphate and hydroxyapatite.
Claim 2
Dependent Claim
164 words
A prosthetic articular cartilage device comprising a dry porous volume matrix of biocompatible and at least bioresorbable fibers and further comprising a base component, said fibers being natural polymers or analogs or mixtures thereof, said matrix being adapted to have an in vivo outer surface contour substantially the same as that of natural articular cartilage, and said matrix having a pore size in the approximate range of about 100 microns to about 400 microns, whereby said matrix establishes a bioresorbable scaffold adapted for the ingrowth of articular chondrocytes, and for supporting natural articulating joint forces, said base component configured to fit in a complementary aperture in cancellous bone thereby securing said articular cartilage device to said bone, said base component extending from portions of the outer surface of said matrix, said base component being a composite material comprising a dispersion of collagen and a composition which is selected from the group consisting of tricalcium phosphate, hydroxyapatite, and a combination of tricalcium phosphate and hydroxyapatite.
Claim 3
Dependent Claim
16 words
The device of claim 1 further comprising crosslinks between at least a portion of said fibers.
Claim 4
Dependent Claim
16 words
The device of claim 1 further comprising a plurality of polysaccharide molecules interspersed with said fibers.
Claim 5
Dependent Claim
20 words
The device of claim 1 wherein at least a portion of said molecules provide crosslinks between ones of said fibers.
Claim 6
Dependent Claim
16 words
The device of claim 1 wherein said fibers are collagen, elastin, reticulin, cellulose, or mixtures thereof.
Claim 7
Dependent Claim
38 words
The device of claim 1 wherein said fibers are present at a concentration of about 75 to 100% by dry weight, and said polysaccharide molecules are present at a concentration of about 0 to 25% by dry weight.
Claim 8
Dependent Claim
29 words
The device of claim 1 wherein said polysaccharide molecules are chondroitin 4-sulfate, chondroitin 6-sulfate, keratan sulfate, dermatan sulfate, heparin sulfate, heparin, hyaluronic acid, alginic acid, chitosan, or mixtures thereof.
Claim 9
Dependent Claim
15 words
The device of claim 1 wherein said crosslinks are formed by a chemical crosslinking agent.
Claim 10
Dependent Claim
26 words
The device of claim 1 wherein said crosslinking agent is glutaraldehyde, formaldehyde, biocompatible bifunctional aldehydes, carbodiimides, hexamethylene diisocyanate, bisimidates, polyglycerol polyglycidyl ether, glyoxal, and mixtures thereof.
Claim 11
Dependent Claim
21 words
The device of claim 1 wherein said cartilage has a density of about 0.07 to 0.50 gram matrix per cubic centimeter.
Claim 12
Dependent Claim
24 words
The device of claim 1 wherein said cartilage has an intrafibrillary and interfibrillary space of about 2 to 14 cubic centimeters per gram matrix.
Claim 13
Dependent Claim
18 words
The device of claim 1 wherein said fibers are oriented in a substantially random fashion through said matrix.
Claim 14
Dependent Claim
18 words
The device of claim 1 wherein said fibers are oriented in a substantially ordered fashion through said matrix.
Claim 15
Dependent Claim
13 words
The device of claim 1 wherein said matrix comprises substantially circumferentially extending fibers.
Claim 16
Dependent Claim
13 words
The device of claim 1 wherein said matrix comprises substantially radially extending fibers.
Claim 17
Dependent Claim
17 words
The device of claim 1 wherein the density of said fibers is substantially uniform throughout said matrix.
Claim 18
Dependent Claim
16 words
The device of claim 1 wherein said polysaccharide molecules are dispersed substantially uniformly through said matrix.
Claim 19
Dependent Claim
15 words
The device of claim 1 wherein said polysaccharide molecules are dispersed nonuniformly through said matrix.
Claim 20
Dependent Claim
14 words
The device of claim 1 wherein the base component is at least partially resorbable.
Claim 21
Dependent Claim
16 words
The device of claim 1 wherein the base component includes a plurality of circumferentially extending ridges.
Claim 22
Dependent Claim
21 words
The device of claim 1 wherein the dispersion comprises about 90% by weight tricalcium phosphate and about 10% by weight collagen.
Claim 23
Dependent Claim
20 words
The device of claim 1 wherein the dispersion comprises about 90% by weight hydroxyapatite and about 10% by weight collagen.
References Cited (Backward Citations)
US3443261A
Cited
US3551560A
Cited
US3855638A
Cited
US4060081A
Cited
GB1515963A
Cited
US4280954A
Cited
US4055862A
Cited
US4064567A
Cited
US4291013A
Cited
US4385404A
Cited
CA1170001A
Cited
US4400833A
Cited
US4350629A
Cited
US4458678A
Cited
US4418691A
Cited
US4505266A
Cited
US4542539A
Cited
WO1983003536A1
Cited
US4787900A
Cited
US4544516A
Cited
US4578079A
Cited
US4589881A
Cited
US4642120A
Cited
US4801299A
Cited
US4448718A
Cited
US4614794A
Cited
US4837285A
Cited
US4620327A
Cited
US4627853A
Cited
US5002583A
Cited
US5123925A
Cited
EP0277678A1
Cited
US4846835A
Cited
US5007934A
Cited
US4880429A
Cited
US5306311A
Cited
WO1989010738A1
Cited
EP0349173A1
Cited
FR2642301A1
Cited
US5108438A
Cited
US5116374A
Cited
WO1990012603A1
Cited
US4963146A
Cited
WO1991016867A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-04-28 | 2000-10-28 | 2001-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-04-28 | 2004-10-28 | 2005-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-04-28 | 2008-10-28 | 2009-04-29 | $7700.00 | Window Closed / Lapsed |