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Patent US5585267A successfully refreshed from Google Patents.
US5585267A
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US
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Cellular attachment to trans-epithelial appliances
Assignee: Desmos Inc
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Filing: 1994-10-03
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Granted: 1996-12-17
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Expires: 2014-10-03
Abstract
Abstract A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix or a soluble factor isolated from the conditioned medium. The appliance will be useful for diminishing inflammation and/or infection at the site of entry of the appliance. The appliance may also be used to stimulate gum junctional epithelium adhesion in the treatment of gingivitis and periodontitis. The composition may be used to maintain tissues ex vivo.
Inventors
- 👤 Jonathan Jones
- 👤 Vito Quaranta
- 👤 Richard Tamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 15:04
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3633; A61L27/14; A61L27/22; A61L27/227; A61L27/28; A61L27/34; A61L27/38; A61L27/3804; A61L27/3813; A61L27/3839; A61L27/3869; A61L27/50; A61L27/60; A61L29/00; A61L29/08; A61L29/085; A61L31/00; A61L31/08; A61L31/10; C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4702; C07K14/4705; C07K14/78; C07K16/00; C07K16/18; C12; C12N; C12N5/00; C12N5/0068; C12N5/06; C12N5/0602; C12N5/0618; C12N5/0621; C12N5/0625; C12N5/0629; C12N5/0676; A61K; A61K35/00; A61K35/12; C12N2502/00; C12N2502/25; C12N2502/253; C12N2533/00; C12N2533/90
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
36 words
An article of manufacture comprising a trans-epithelial appliance coated with a soluble hemidesmosome formation-inducing factor obtainable from 804G or NBT-II rat bladder carcinoma cells, wherein the factor induces epithelial cell attachment to the coated trans-epithelial appliance.
Claim 2
Dependent Claim
36 words
An article of manufacture comprising a trans-epithelial appliance coated with a soluble hemidesmosome formation-inducing factor obtainable from 804G or NBT-II rat bladder carcinoma cells, wherein the factor induces epithelial cell attachment to the coated trans-epithelial appliance.
Claim 3
Dependent Claim
33 words
The article of claim 1, wherein said appliance is a shaped article selected from the group consisting of indwelling catheter, needle, metal pin, metal rod, colostomy tube, dental abutment piece and surgical mesh.
Claim 4
Dependent Claim
15 words
The article of claim 1, further comprising epithelial cells deposited on said hemidesmosome formation-inducing composition.
Claim 5
Dependent Claim
12 words
The article of claim 1, wherein said appliance is used in vivo.
Claim 6
Dependent Claim
17 words
The article of claim 1, wherein said appliance is made of or coated with a biocompatible metal.
Claim 7
Dependent Claim
13 words
The article of claim 5, wherein said metal is stainless steel or titanium.
Claim 8
Dependent Claim
17 words
The article of claim 1, wherein said appliance is made of or coated with a ceramic material.
Claim 9
Dependent Claim
10 words
The article of claim 7, wherein said material is hydroxyapatite.
Claim 10
Dependent Claim
16 words
The article of claim 1, wherein said appliance is made of or coated with a polymer.
Claim 11
Dependent Claim
23 words
The article of claim 9, wherein said polymer is selected from the group consisting of polyester, polyglycolic acid and a polygalactose-polyglycolic acid copolymer.
Claim 12
Independent Claim
58 words
A method for inducing epithelial cell attachment to a trans-epithelial appliance comprising the following steps: (a) coating a trans-epithelial appliance with a soluble hemidesmosome formation-inducing factor obtainable from 804G or NBT-II rat bladder carcinoma cells, and (b) incubating the coated trans-epithelial appliance with epithelial cells under conditions necessary to induce epithelial cell attachment to the coated trans-epithelial appliance.
Claim 13
Independent Claim
58 words
A method for inducing epithelial cell attachment to a trans-epithelial appliance comprising the following steps: (a) coating a trans-epithelial appliance with a soluble hemidesmosome formation-inducing factor obtainable from 804G or NBT-II rat bladder carcinoma cells, and (b) incubating the coated trans-epithelial appliance with epithelial cells under conditions necessary to induce epithelial cell attachment to the coated trans-epithelial appliance.
Claim 14
Dependent Claim
30 words
The method of claim 11, wherein said appliance is selected from the group consisting of indwelling catheter, needle, metal pin, metal rod, colostomy tube, dental abutment piece and surgical mesh.
Claim 15
Dependent Claim
16 words
The method of claim 11, wherein said appliance is made of or coated with a polymer.
Claim 16
Dependent Claim
23 words
The method of claim 13, wherein said polymer is selected from the group consisting of polyester, polyglycolic acid and a polygalactose-polyglycolic acid copolymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-17 | 2000-06-17 | 2000-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-17 | 2004-06-17 | 2004-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-17 | 2008-06-17 | 2008-12-17 | $7700.00 | Window Closed / Lapsed |