US5550172A — Utilization of biocompatible adhesive/sealant mat…

Claim 1

Independent Claim 232 words

A process for enhancing the security of implantable surgical devices secured to bone tissue consisting essentially of securing a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a bioabsorbable semi-crystalline aliphatic poly(ester) of the formula: [--0--R.sup.11 --C(O)--].sub.Y, wherein R 11 is selected from the group consisting of --CR 12 H--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, CR 12 H--CH 2 , --(CH 2 ) 4 --, --(CH 2 ) z --O--C(O)-- and --(CH 2 ) z --C(O)--CH 2 --; R 12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (b) a slurry of water and a calcium containing compound with the general formula: M.sup.2 +.sub.10-n N.sup.1 +.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.x- where n is an integer form 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO 4 is an acid radical and W is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO 3 2-- ); and U is a halide hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 2

Dependent Claim 232 words

A process for enhancing the security of implantable surgical devices secured to bone tissue consisting essentially of securing a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a bioabsorbable semi-crystalline aliphatic poly(ester) of the formula: [--0--R.sup.11 --C(O)--].sub.Y, wherein R 11 is selected from the group consisting of --CR 12 H--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, CR 12 H--CH 2 , --(CH 2 ) 4 --, --(CH 2 ) z --O--C(O)-- and --(CH 2 ) z --C(O)--CH 2 --; R 12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (b) a slurry of water and a calcium containing compound with the general formula: M.sup.2 +.sub.10-n N.sup.1 +.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.x- where n is an integer form 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO 4 is an acid radical and W is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO 3 2-- ); and U is a halide hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 3

Dependent Claim 24 words

The process of claim 1 wherein the sealant and/or adhesive is applied to the site where the implantable surgical device is to be secured.

Claim 4

Dependent Claim 29 words

The process of claim 1 wherein the surgical device is selected from the group consisting of screws, pins, plates, anchors, rods, clamps, clips, staples, rivets, hooks, buttons and snaps.

Claim 5

Dependent Claim 16 words

The process of claim 1 wherein the surgical device is made of a bioabsorbable polymeric material.

Claim 6

Dependent Claim 28 words

The process of claim 1 wherein the adhesive and/or sealant is a bioabsorbable semi-crystalline aliphatic poly(ester) homopolymer selected from the group consisting of poly(ε-caprolactone), poly(p-dioxanone), and poly(trimethylene carbonate).

Claim 7

Dependent Claim 104 words

A process for enhancing the security of implantable surgical devices secured to bone tissue comprising securing a surgical device to bone with a bioabsorbable semi-crystalline aliphatic poly(ester) copolymer composed of from about 100 mole percent to about 70 mole percent of ε-caprolactone repeating units with the remainder of the polymer being a plurality of second lactone repeating unit selected from the group consisting of glycolide repeating units, lactide repeating units, 1,4-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1,5-dioxepan-2-one repeating units, trimethylene carbonate repeating units, and combinations thereof provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 8

Dependent Claim 104 words

A process for enhancing the security of implantable surgical devices secured to bone tissue comprising securing a surgical device to bone with a bioabsorbable semi-crystalline aliphatic poly(ester) copolymer composed of from about 100 mole percent to about 70 mole percent of ε-caprolactone repeating units with the remainder of the polymer being a plurality of second lactone repeating unit selected from the group consisting of glycolide repeating units, lactide repeating units, 1,4-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1,5-dioxepan-2-one repeating units, trimethylene carbonate repeating units, and combinations thereof provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 9

Dependent Claim 28 words

The process of claim 1 wherein the adhesive and/or sealant is applied to the implantable surgical device and the surgical device is then secured to the bone tissue.

Claim 10

Dependent Claim 228 words

An implantable surgical device consisting essential of an implantable surgical device that is at least partially coated with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a bioabsorbable semi-crystalline aliphatic poly(ester) of the formula: [--O--R.sup.11 --C(O)--].sub.Y, wherein R 11 is selected from the group consisting of --CR 12 H--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, CR 12 H--CH 2 , --(CH 2 ) 4 --, --(CH 2 ) Z --O--C(O)-- and --(CH 2 ) z --C(O)--CH 2 --; R 12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (b) a slurry of water and a calcium containing compound with the general formula: M.sup.2 +.sub.10-n N.sup.1+.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.x - where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO 4 is an acid radical and W is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO 3 2- ); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 11

Dependent Claim 228 words

An implantable surgical device consisting essential of an implantable surgical device that is at least partially coated with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a bioabsorbable semi-crystalline aliphatic poly(ester) of the formula: [--O--R.sup.11 --C(O)--].sub.Y, wherein R 11 is selected from the group consisting of --CR 12 H--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, CR 12 H--CH 2 , --(CH 2 ) 4 --, --(CH 2 ) Z --O--C(O)-- and --(CH 2 ) z --C(O)--CH 2 --; R 12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (b) a slurry of water and a calcium containing compound with the general formula: M.sup.2 +.sub.10-n N.sup.1+.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.x - where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO 4 is an acid radical and W is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO 3 2- ); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 12

Dependent Claim 30 words

The surgical devices of claim 8 wherein the surgical device is selected from the group consisting of screws, pins, plates, anchors, rods, clamps, clips, staples, rivets, hooks, buttons and snaps.

Claim 13

Dependent Claim 17 words

The surgical device of claim 8 wherein the surgical device is made of a bioabsorbable polymeric material.

Claim 14

Dependent Claim 37 words

The surgical device of claim 8 wherein the adhesive and/or sealant that at least partially coats the surgical device is a bioabsorbable semi-crystalline aliphatic poly(ester) homopolymer selected from the group consisting of poly(ε-caprolactone), poly(p-dioxanone), and poly(trimethylene carbonate).

Claim 15

Dependent Claim 98 words

An implantable surgical device comprising an implantable surgical device that is at least partially coated with a bioabsorbable semi-crystalline aliphatic poly(ester) copolymer composed of from about 100 mole percent to about 70 mole percent of ε-caprolactone repeating units with the remainder of the polymer being a plurality of second lactone repeating units selected from the group consisting of glycolide repeating units, lactide repeating units, 1,4-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1,5-dioxepan-2-one repeating units, trimethylene carbonate repeating units, and combinations thereof provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Claim 16

Dependent Claim 98 words

An implantable surgical device comprising an implantable surgical device that is at least partially coated with a bioabsorbable semi-crystalline aliphatic poly(ester) copolymer composed of from about 100 mole percent to about 70 mole percent of ε-caprolactone repeating units with the remainder of the polymer being a plurality of second lactone repeating units selected from the group consisting of glycolide repeating units, lactide repeating units, 1,4-dioxanone repeating units, 1,4-dioxepan-2-one repeating units, 1,5-dioxepan-2-one repeating units, trimethylene carbonate repeating units, and combinations thereof provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1999-08-27	2000-02-26	2000-08-27	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2003-08-27	2004-02-26	2004-08-27	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2007-08-27	2008-02-26	2008-08-27	$7700.00	Window Closed / Lapsed

Utilization of biocompatible adhesive/sealant materials for securing surgical devices

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