US5281265A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Resorbable surgical cements
Assignee: Ceramedical Inc
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Filing: 1992-02-03
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Granted: 1994-01-25
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Expires: 2012-02-03
Abstract
Abstract A new surgical cement is disclosed. This surgical cement comprises a hardened cement formed from a mixture comprising a cementing component selected from the group consisting of calcium components having a solubility in water at 25° C. in the range of about 0.5 × 10 -2 M to about 20 × 10 -2 M and mixtures thereof; a setting component selected from the group consisting of water soluble salts of polyfunctional carboxylic acids containing 2 to about 10 carbon atoms, water soluble dibasic phosphate salts and mixtures thereof; and water in an amount effective to form a paste from the mixture which paste hardens into said hardened cement which is biocompatible.
Inventors
- 👤 Sung-Tsuen Liu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:03
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/02; A61L27/025; A61K; A61K6/00; A61K6/15; A61K6/17; A61K6/60; A61K6/69; A61K6/70; A61K6/71; A61K6/74; A61K6/75; A61K6/77; A61K6/80; A61K6/802; A61K6/807; A61K6/849; A61K6/858; A61K6/864; A61K6/876; A61L27/12; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
156 words
A surgical cement for use in medical applications such as orthopedic and maxillofacial surgeries and dental applications comprising a hardened cement formed from a mixture comprising a cementing component selected from the group consisting of calcium sulfate-containing components, calcium succinate, calcium malate, calcium malonate, calcium maleate, hydrates thereof and mixtures thereof, said cementing component having a solubility in water at 25° C. in the range of about 0.5×10 -2 M to about 20×10 -2 M; a setting component selected from the group consisting of water soluble, neutral salts of polyfunctional carboxylic acids containing 2 to about 10 carbon atoms, water soluble dibasic phosphate salts and mixtures thereof; and water in an amount effective to form a paste from said mixture which paste hardens into said hardened cement which is biocompatible, provided that the weight ratio of said cementing component to said setting component in said mixture is in the range of about 1:1 to about 5:1.
Claim 2
Dependent Claim
156 words
A surgical cement for use in medical applications such as orthopedic and maxillofacial surgeries and dental applications comprising a hardened cement formed from a mixture comprising a cementing component selected from the group consisting of calcium sulfate-containing components, calcium succinate, calcium malate, calcium malonate, calcium maleate, hydrates thereof and mixtures thereof, said cementing component having a solubility in water at 25° C. in the range of about 0.5×10 -2 M to about 20×10 -2 M; a setting component selected from the group consisting of water soluble, neutral salts of polyfunctional carboxylic acids containing 2 to about 10 carbon atoms, water soluble dibasic phosphate salts and mixtures thereof; and water in an amount effective to form a paste from said mixture which paste hardens into said hardened cement which is biocompatible, provided that the weight ratio of said cementing component to said setting component in said mixture is in the range of about 1:1 to about 5:1.
Claim 3
Dependent Claim
21 words
The surgical cement of claim 1 wherein said hardened cement has a surface which is substantially neutral of alkaline in character.
Claim 4
Dependent Claim
40 words
The surgical cement of claim 1 wherein said cementing component is selected from the group consisting of calcium sulfate-containing components, hydrates thereof and mixtures thereof, and said mixture hardens in about 20 minutes or less after said paste is formed.
Claim 5
Dependent Claim
40 words
The surgical cement of claim 1 wherein said cementing component is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, anhydrous calcium sulfate, calcium sulfate-calcium phosphate mixed ceramics, calcium sulfate-calcium alkali phosphate mixed ceramics and mixtures thereof.
Claim 6
Dependent Claim
29 words
The surgical cement of claim 1 wherein said cementing component is selected from the group consisting of calcium sulfate dihydrate, calcium sulfate hemihydrate, anhydrous calcium sulfate and mixtures thereof.
Claim 7
Dependent Claim
31 words
The surgical cement of claim 1 wherein said cementing component is selected from the group consisting of calcium sulfate-calcium phosphate mixed ceramics, calcium sulfate-calcium alkali phosphate mixed ceramics and mixtures thereof.
Claim 8
Dependent Claim
25 words
The surgical cement of claim 1 wherein said cementing component is selected from the group consisting of calcium sulfate-calcium alkali phosphate ceramics and mixtures thereof.
Claim 9
Dependent Claim
35 words
The surgical cement of claim 1 wherein said cementing component is combined in said mixture in the form of particles having a particle size in the range of about 3 microns to about 400 microns.
Claim 10
Dependent Claim
25 words
The surgical cement of claim 1 wherein said setting component is selected from the group consisting of citrates, tartrates, dibasic phosphate salts and mixtures thereof.
Claim 11
Dependent Claim
18 words
The surgical cement of claim 1 wherein said setting component is selected from the group consisting of citrates.
Claim 12
Dependent Claim
36 words
The surgical cement of claim 10 wherein said setting component is selected from the group consisting of ammonium citrate, alkali metal citrates, alkaline earth metal citrates, ferrous citrate, ferric citrate, ferric ammonium citrate and mixtures thereof.
Claim 13
Dependent Claim
19 words
The surgical cement of claim 10 wherein said mixture further comprises an effective amount of a strength enhancing component.
Claim 14
Dependent Claim
27 words
The surgical component of claim 12 wherein said strength enhancing component is selected from the group consisting of soluble tartrates, soluble dibasic phosphate salts, and mixtures thereof.
Claim 15
Dependent Claim
50 words
The surgical cement of claim 12 wherein strength enhancing component is selected from the group consisting of Na 2 HPO 4 , K 2 HPO 4 , MgHPO 4 , (NH 4 ) 2 HPO 4 , Na 2 tartrate, K 2 tartrate, NaK tartrate, ammonium tartrate and mixtures thereof.
Claim 16
Dependent Claim
35 words
The surgical cement of claim 1 wherein said mixture further comprises a biocompatible filler component which is substantially inert with respect to the interaction between said cementing component and said setting component during said hardening.
Claim 17
Dependent Claim
55 words
The surgical cement of claim 15 wherein said biocompatible filler component is selected from the group consisting of tetracalcium phosphate, tricalcium phosphate, calcium alkali phosphate ceramic, bioglass, calcium carbonate, calcium hydroxide, calcium oxide, calcium fluoride, magnesium hydroxide, hydroxyapatite, calcium phosphorus apatite, magnesium oxide, magnesium carbonate, magnesium fluoride, collagen, other resorbable biocompatible materials and mixtures thereof.
Claim 18
Dependent Claim
25 words
The surgical cement of claim 15 wherein said biocompatible filler component is selected from the group consisting of hydroxyapatite, calcium phosphorus apatite and mixtures thereof.
Claim 19
Dependent Claim
36 words
The surgical cement of claim 15 wherein said biocompatible filler component is combined in said mixture in the form of particles having a particle size in the range of about 3 microns to about 400 microns.
Claim 20
Dependent Claim
11 words
The surgical element of claim 1 further comprises an antibiotic component.
Claim 21
Dependent Claim
13 words
The surgical cement of claim 1 further comprises a bone growth protein component.
References Cited (Backward Citations)
US4612053A
Cited
US4619655A
Cited
US4668295A
Cited
US4911759A
Cited
US5141561A
Cited
US5149368A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-01-24 | 1997-07-26 | 1998-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-24 | 2001-07-26 | 2002-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-24 | 2005-07-26 | 2006-01-25 | $7700.00 | Window Closed / Lapsed |