US3995641A
Expired / Lapsed
US
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Surgical adhesives
Assignee: Ethicon Inc
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Filing: 1975-04-23
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Granted: 1976-12-07
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Expires: 1995-04-23
Abstract
Abstract Carbalkoxyalkyl 2-cyanoacrylates having the formula: ##STR1## wherein R is an organic radical and R' is hydrogen or methyl polymerize rapidly in the presence of moisture and are useful as adhesives. When applied as tissue adhesives in surgical applications, such carbalkoxyalkyl 2-cyanoacrylates cause a minimum of tissue reaction and the resulting polymer is absorbable in mammalian tissue.
Inventors
- 👤 Richard L. Kronenthal
- 👤 Edgar Schipper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:33
CPC Classifications
C; C07; C07C; C07C255/00; A; A61; A61L; A61L24/00; A61L24/04; A61L24/06; C09; C09J; C09J4/00
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
27 words
A composition of the formula: ##STR7## wherein D is a cyclic 1,3 diene and R is an organic radical having from 1 to about 12 carbon atoms.
Claim 2
Dependent Claim
27 words
A composition of the formula: ##STR7## wherein D is a cyclic 1,3 diene and R is an organic radical having from 1 to about 12 carbon atoms.
Claim 3
Dependent Claim
9 words
A composition of claim 1 wherein D is ##STR8##
Claim 4
Dependent Claim
36 words
A composition of claim 2 wherein R is alkyl, alkenyl, or alkynyl or a halo- or alkoxy-substituted alkyl, alkenyl, or alkynyl group having from 1 to about 8 carbon atoms, cycloalkyl, aralkyl, aryl or substituted aryl.
Claim 5
Dependent Claim
16 words
A composition of claim 2 wherein R is alkyl having from 4 to 6 carbon atoms.
Claim 6
Dependent Claim
22 words
A composition of claim 2 wherein R is methyl, ethyl, allyl, n-butyl, isobutyl, hexyl, octyl, propargyl, 2-butoxyethyl, 2-ethoxyethyl, 2,2,2,-trifluoroethyl, cyclohexyl or benzyl.
Claim 7
Dependent Claim
28 words
A composition of the formula: ##STR9## wherein R is an organic radical having from 1 to about 12 carbon atoms and each R' is individually hydrogen or methyl.
Claim 8
Dependent Claim
28 words
A composition of the formula: ##STR9## wherein R is an organic radical having from 1 to about 12 carbon atoms and each R' is individually hydrogen or methyl.
Claim 9
Dependent Claim
36 words
A composition of claim 6 wherein R is alkyl, alkenyl, or alkynyl or a halo or alkoxy-substituted alkyl, alkenyl, or alkynyl group having from 1 to about 8 carbon atoms, cycloalkyl, aralkyl, aryl or substituted aryl.
Claim 10
Dependent Claim
10 words
A composition of claim 6 wherein each R' is hydrogen.
Claim 11
Dependent Claim
16 words
A composition of claim 8 wherein R is alkyl having from 4 to 6 carbon atoms.
Claim 12
Dependent Claim
22 words
A composition of claim 8 wherein R is methyl, ethyl, allyl, n-butyl, isobutyl, hexyl, octyl, propargyl, 2-butoxyethyl, 2-ethoxyethyl, 2,2,2,-trifluoroethyl, cyclohexyl or benzyl.
Claim 13
Dependent Claim
32 words
A method of joining together two surfaces which comprises applying to at least one of said surfaces a compound of claim 6 and maintaining the surfaces in contact until said compound polymerizes.
Claim 14
Dependent Claim
11 words
A method of claim 11 wherein said surfaces comprise body tissue.
Claim 15
Dependent Claim
21 words
A method of claim 11 wherein one of said surfaces is body tissue and the other surface is a prosthetic device.
Claim 16
Dependent Claim
28 words
A method for repairing damaged living tissue to prevent the escape of fluids therethrough which comprises sealing said tissue with a film of a composition of claim 6.
Claim 17
Dependent Claim
26 words
A method for stemming the flow of blood from small vessels which comprises sealing said vessels with a hemostatic agent comprising a composition of claim 6.
Claim 18
Dependent Claim
26 words
A method of dressing burns to promote the healing thereof which comprises covering said burn with a precast film of a polymerized composition of claim 6.
Claim 19
Dependent Claim
26 words
A method of dressing wounds to promote the healing thereof which comprises covering said wound with a precast film of a polymerized composition of claim 6.
Claim 20
Dependent Claim
24 words
A method of dressing burns to promote the healing thereof which comprises coating the surface of said burn with a composition of claim 6.
Claim 21
Dependent Claim
24 words
A method of dressing wounds to promote the healing thereof which comprises coating the surface of said wound with a composition of claim 6.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-07 | 1980-06-07 | 1980-12-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-07 | 1984-06-07 | 1984-12-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-07 | 1988-06-07 | 1988-12-07 | $7700.00 | Window Closed / Lapsed |