US4902649A
Expired / Lapsed
US
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Hard tissue substitute composition
Assignee: Resonac Holdings Corp
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Filing: 1987-09-10
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Granted: 1990-02-20
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Expires: 2007-09-10
Abstract
Abstract A composition for use in forming a hard tissue substitute comprising (A) a powder ingredient mainly comprised of Ca n+2 (PO 4 ) 2 O n-1 , where n is from 1.9 to 4.9 and (B) an aqueous solution of an organic acid, preferably of the TCA cycle, or a polymer of an organic acid. This composition has a good affinity with living organisms, a high compressive strength, and a low disintegration rate.
Inventors
- 👤 Yoshitaka Kimura
- 👤 Yuji Furuta
- 👤 Kunihiro Miyazaki
- 👤 Tadashi Hiraiwa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 06:40
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61K; A61K6/00; A61K6/50; A61K6/54; A61K6/80; A61K6/831; A61K6/838; A61K6/849; A61K6/864; A61K6/873; A61L24/00; A61L24/0047; A61L24/0073; A61L24/0089; A61L24/02; A61L27/02; A61L27/12; A61F; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
105 words
A composition which is hardenable by a chelate reaction for use in forming a hard tissue substitute in situ comprising: (A) a powder ingredient mainly comprised of Ca n+2 (PO 4 ) 2 O n-1 where n is from 1.9 to 4.8, and (B) an aqueous solution of an organic acid or a polymer thereof, wherein said aqueous solution (B) comprises from 25 to 60% by weight of said organic acid or polymer thereof, and wherein the composition is mixed in a ratio of 1.0 to 2.2 parts by weight of said powder ingredient (A) per 1.0 part by weight of said aqueous solution (B).
Claim 2
Dependent Claim
105 words
A composition which is hardenable by a chelate reaction for use in forming a hard tissue substitute in situ comprising: (A) a powder ingredient mainly comprised of Ca n+2 (PO 4 ) 2 O n-1 where n is from 1.9 to 4.8, and (B) an aqueous solution of an organic acid or a polymer thereof, wherein said aqueous solution (B) comprises from 25 to 60% by weight of said organic acid or polymer thereof, and wherein the composition is mixed in a ratio of 1.0 to 2.2 parts by weight of said powder ingredient (A) per 1.0 part by weight of said aqueous solution (B).
Claim 3
Dependent Claim
19 words
A composition according to claim 1, wherein said powder ingredient additionally comprises tricalcium phosphate, hydroxy apatite and calcium oxide.
Claim 4
Dependent Claim
26 words
A composition according to claim 2, wherein said powder ingredient comprises more than 80% by weight of Ca n+2 (PO 4 ) 2 O n-1 .
Claim 5
Dependent Claim
19 words
A composition according to claim 1, wherein said powder ingredient has a diameter of less than about 44 μm.
Claim 6
Dependent Claim
16 words
A composition according to claim 1, wherein said powder ingredient further comprises an X-ray contrast media.
Claim 7
Dependent Claim
23 words
A composition according to claim 1, wherein said aqueous solution comprises an organic acid of the tricarboxylic acid cycle of a human body.
Claim 8
Dependent Claim
33 words
A composition according to claim 6, wherein said organic acid of the tricarboxylic acid cycle of the human body is selected from the group consisting of citric acid, malic acid, and aspartic acid.
Claim 9
Dependent Claim
22 words
A composition according to claim 1, wherein said aqueous solution comprises an organic acid other than those of the tricarboxylic acid cycle.
Claim 10
Dependent Claim
21 words
A composition according to claim 1, wherein said aqueous solution comprises a polymer of an unsaturated monomer having a carboxylic group.
Claim 11
Dependent Claim
26 words
A composition according to claim 1, wherein said aqueous solution includes an inorganic acid selected from the group consisting of phosphoric acid and a chloric acid.
Claim 12
Dependent Claim
20 words
A composition according to claim 10, wherein said aqueous solution includes 0.5 to 5% by weight of said inorganic acid.
Claim 13
Dependent Claim
30 words
A composition according to claim 1, wherein said tetracalcium phosphate has a chemical formula of Ca n+2 (PO 4 ) 2 O n-1 where n is from 1.9 to 2.2.
Claim 14
Dependent Claim
46 words
A composition according to claim 8, wherein said organic acid other than those of the tricarboxylic acid cycle of the human body is selected from the group consisting of malonic acid, tartaric acid, lactic acid, pyruvic acid, oxalic acid, acrylic acid, maleic acid and itaconic acid.
Claim 15
Dependent Claim
14 words
A composition according to claim 1, wherein said composition is hardened at ambient temperature.
Claim 16
Dependent Claim
92 words
A composition which is hardenable by a chelate reaction for use in forming a hard tissue substitute in situ comprising: (A) a powder ingredient mainly comprised of tetracalcium phosphate, and (B) an aqueous solution of an organic acid or a polymer thereof, wherein said aqueous solution (B) comprises from 25 to 60% by weight of said organic acid or polymer thereof, and wherein the composition is mixed in a ratio of 1.0 to 2.2 parts by weight of said powder ingredient (A) per 1.0 part by weight of said aqueous solution (B).
Claim 17
Dependent Claim
92 words
A composition which is hardenable by a chelate reaction for use in forming a hard tissue substitute in situ comprising: (A) a powder ingredient mainly comprised of tetracalcium phosphate, and (B) an aqueous solution of an organic acid or a polymer thereof, wherein said aqueous solution (B) comprises from 25 to 60% by weight of said organic acid or polymer thereof, and wherein the composition is mixed in a ratio of 1.0 to 2.2 parts by weight of said powder ingredient (A) per 1.0 part by weight of said aqueous solution (B).
Claim 18
Dependent Claim
14 words
A composition according to claim 15, wherein said composition is hardened at ambient temperature.
References Cited (Backward Citations)
US3982543A
Cited
US4141864A
Cited
US4207306A
Cited
US4192021A
Cited
US4113500A
Cited
US4268639A
Cited
US4376168A
Cited
US4457028A
Cited
US4610692A
Cited
US4518430A
Cited
US4661530A
Cited
US4550449A
Cited
JPS59182263A
Cited
US4554686A
Cited
JPS60253454A
Cited
US4629464A
Cited
US4661536A
Cited
US4693986A
Cited
US4645503A
Cited
US4719149A
Cited
JPH06171060A
Cited
JPH06168054A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-19 | 1993-08-21 | 1994-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-19 | 1997-08-21 | 1998-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-19 | 2001-08-21 | 2002-02-20 | $7700.00 | Window Closed / Lapsed |