Patent US5547878A successfully refreshed from Google Patents.
US5547878A
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Method of monitoring patient compliance with medications prescriptions
Assignee: PROGRESSION Ltd
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Filing: 1994-05-24
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Granted: 1996-08-20
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Expires: 2014-05-24
Abstract
Abstract A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage by determining a normalized urine methadone concentration. An unadulterated urine sample is obtained from the patient. The urine methadone concentration and urine specific gravity are measured. The normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine and the urine specific gravity. The calculated normalized urine medication concentration is compared with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance. Alternatively, a urinary-parameter normalized urine medication concentration is calculated as a function of the measured medication concentration in the urine, the urine specific gravity and at least one selected pharmacokinetic parameter of the medication. The calculated urinary-parameter normalized urine medication concentration is compared with an expected medication concentration value for an average compliant patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.
Inventors
- 👤 Michael Kell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:00
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/493; Y; Y10; Y10S; Y10S436/00; Y10S436/807; Y10S436/808; Y10S436/901; Y10T; Y10T436/00; Y10T436/17; Y10T436/173845
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
155 words
A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage, and with the method comprising the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of the medication or its metabolites in the urine and the urine specific gravity, (c) calculating a normalized urine medication concentration as a function of the measured medication concentration in the urine and the urine specific gravity in accordance with the equation un=u·(k.sub.1 ·SGF-k.sub.2) where nu is the normalized urine medication concentration, u is the measured concentration of medication in the urine, SGF is the specific gravity factor of the urine sample, and k 1 and k 2 are constants, and (d) comparing the normalized urine medication concentration with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.
Claim 2
Independent Claim
155 words
A method of monitoring compliance of a patient that has been placed on a medication maintenance program with a prescribed medication dosage, and with the method comprising the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of the medication or its metabolites in the urine and the urine specific gravity, (c) calculating a normalized urine medication concentration as a function of the measured medication concentration in the urine and the urine specific gravity in accordance with the equation un=u·(k.sub.1 ·SGF-k.sub.2) where nu is the normalized urine medication concentration, u is the measured concentration of medication in the urine, SGF is the specific gravity factor of the urine sample, and k 1 and k 2 are constants, and (d) comparing the normalized urine medication concentration with an expected medication concentration value for the patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.
Claim 3
Independent Claim
208 words
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program with a prescribed methadone dosage, and with the method comprising the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of methadone in the urine, the specific gravity of the urine and the pharmacokinetic parameters of the medication including methadone dose, patient body weight, and urine pH, (c) calculating a urinary-parameter normalized urine methadone concentration as a function of the measured methadone concentration in the urine, the urine specific gravity, the methadone dose, patient body weight, and urine pH, in accordance with the equation nu.sub.p =(k.sub.3 /DOSE).sup.k4 ·(k.sub.5 /pH).sup.-k6 ·WGT/k.sub.7 ·u·(k.sub.1 ·SGF-k.sub.2) where nu p is the urinary-parameter normalized urine methadone concentration, DOSE is the prescribed methadone dose, pH is the pH of the urine sample, WGT is the patient body weight, SGF is the specific gravity factor of the urine sample, u is the measured concentration of methadone in the urine sample, and k 1 -k 7 are constants, and (d) comparing the urinary-parameter normalized urine methadone concentration with an expected methadone concentration value for an average compliant patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.
Claim 4
Independent Claim
208 words
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program with a prescribed methadone dosage, and with the method comprising the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of methadone in the urine, the specific gravity of the urine and the pharmacokinetic parameters of the medication including methadone dose, patient body weight, and urine pH, (c) calculating a urinary-parameter normalized urine methadone concentration as a function of the measured methadone concentration in the urine, the urine specific gravity, the methadone dose, patient body weight, and urine pH, in accordance with the equation nu.sub.p =(k.sub.3 /DOSE).sup.k4 ·(k.sub.5 /pH).sup.-k6 ·WGT/k.sub.7 ·u·(k.sub.1 ·SGF-k.sub.2) where nu p is the urinary-parameter normalized urine methadone concentration, DOSE is the prescribed methadone dose, pH is the pH of the urine sample, WGT is the patient body weight, SGF is the specific gravity factor of the urine sample, u is the measured concentration of methadone in the urine sample, and k 1 -k 7 are constants, and (d) comparing the urinary-parameter normalized urine methadone concentration with an expected methadone concentration value for an average compliant patient for the maintenance program prescribed to determine any significant differences therebetween as an indication of noncompliance.
Claim 5
Independent Claim
155 words
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program which comprises the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample, (c) calculating the concentration of methadone of the plasma as a function of the measured concentration of methadone of the urine, urine specific gravity and urine pH in accordance with the equation p=k.sub.3 u·(k.sub.1 SGF-k.sub.2)/k.sub.4 ·pH.sup.k5 where p is the calculated plasma methadone concentration, u is the measured urine methadone concentration, SGF is the specific gravity factor of the patient's urine, pH is the measured pH value of the urine, and k 1 , k 2 , k 3 , k 4 , and k 5 are constants, and (d) comparing the calculated concentration of methadone of the plasma with an expected value for the maintenance program prescribed.
Claim 6
Independent Claim
155 words
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program which comprises the steps of (a) obtaining a sample of the patient's urine, (b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample, (c) calculating the concentration of methadone of the plasma as a function of the measured concentration of methadone of the urine, urine specific gravity and urine pH in accordance with the equation p=k.sub.3 u·(k.sub.1 SGF-k.sub.2)/k.sub.4 ·pH.sup.k5 where p is the calculated plasma methadone concentration, u is the measured urine methadone concentration, SGF is the specific gravity factor of the patient's urine, pH is the measured pH value of the urine, and k 1 , k 2 , k 3 , k 4 , and k 5 are constants, and (d) comparing the calculated concentration of methadone of the plasma with an expected value for the maintenance program prescribed.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-08-20 | 2000-02-19 | 2000-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-08-20 | 2004-02-19 | 2004-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-08-20 | 2008-02-19 | 2008-08-20 | $7700.00 | Window Closed / Lapsed |