US5525356A
Expired / Lapsed
US
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Amphoteric N-substituted acrylamide hydrogel and method
Assignee: Medtronic Inc
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Filing: 1991-03-29
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Granted: 1996-06-11
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Expires: 2011-03-29
Abstract
Abstract A polymeric, amphoteric hydrogel for use in medical devices and medical devices using the hydrogel. The hydrogel has a first polymer repeating unit having a acid group and a second polymer repeating unit having a base group such that the acid groups and base groups are present in the hydrogel in amounts effective to provide a hydrogel with a strong, amphoteric, nonmobile ionic structure. For example, the hydrogel can be a copolymer of 2-acrylamido-2-methylpropane sulfonic acid and methacrylamido-propyl-trimethylammonium hydroxide. The hydrogel can be an adhesive used to adhere medical devices to the skin of a patient. It can be particularly useful in drug delivery applications such as in iontophoresis devices.
Inventors
- 👤 Allan H. Jevne
- 👤 Carolann Holmblad
- 👤 Joseph B. Phipps
- 👤 Warren W. Howland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 10:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7061; A61K47/00; A61K47/30; A61K47/32; A61K9/0002; A61K9/0009; A61K9/0012; A61K9/0014; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/60; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/0404; A61N1/0408; A61N1/0428; C; C08; C08L; C08L33/00; C08L33/02; C09; C09J; C09J133/00; C09J133/24; C09J133/26; C08L2666/00; C08L2666/02; C08L2666/04
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
79 words
An amphoteric, hydrophilic hydrogel adhesive for adhering medical devices to human skin comprising a copolymer having: first polymer repeating units having a pendant strong acid group selected from the group consisting of carboxylic acid, phosphoric acid, phenolic acid or sulfonic acid; and second polymer repeating units having a pendant strong base group selected from the group consisting of quaternary ammonium salts and protonated amines, at least one of said first and second polymer repeating units being an N-substituted acrylamide.
Claim 2
Dependent Claim
79 words
An amphoteric, hydrophilic hydrogel adhesive for adhering medical devices to human skin comprising a copolymer having: first polymer repeating units having a pendant strong acid group selected from the group consisting of carboxylic acid, phosphoric acid, phenolic acid or sulfonic acid; and second polymer repeating units having a pendant strong base group selected from the group consisting of quaternary ammonium salts and protonated amines, at least one of said first and second polymer repeating units being an N-substituted acrylamide.
Claim 3
Dependent Claim
29 words
The hydrogel of claim 1 wherein the mole ratio of first polymeric repeating units to second polymeric repeating units is in the range of about 10:1 to about 1:10.
Claim 4
Dependent Claim
18 words
The hydrogel of claim 1 wherein the hydrogel includes as its first polymeric repeating unit an N-substituted acrylamide.
Claim 5
Dependent Claim
12 words
The hydrogel of claim 3 wherein the N-substituted acrylamide is 2-acrylamido-2-methylpropanesulfonic acid.
Claim 6
Dependent Claim
47 words
An amphoteric, hydrophilic hydrogel for adhering medical devices to human skin comprising: a copolymer having as a first polymer repeating unit component an N-substituted acrylamide having a pendant sulfonic acid group and as a second polymer repeating unit component an N-substituted acrylamide having a pendant base group.
Claim 7
Dependent Claim
47 words
An amphoteric, hydrophilic hydrogel for adhering medical devices to human skin comprising: a copolymer having as a first polymer repeating unit component an N-substituted acrylamide having a pendant sulfonic acid group and as a second polymer repeating unit component an N-substituted acrylamide having a pendant base group.
Claim 8
Dependent Claim
12 words
The hydrogel of claim 5 wherein the N-substituted acrylamide is 2-acrylamido-2-methylpropanesulfonic acid.
Claim 9
Dependent Claim
14 words
The hydrogel of claim 5 wherein the second polymer repeating unit is methacrylamido-propyl-trimethylammonium hydroxide.
Claim 10
Dependent Claim
32 words
The hydrogel of claim 5 wherein the mole ratio of the first polymer repeating unit component to the second polymer repeating unit component is in the range of about 10:1 to 1:10.
Claim 11
Dependent Claim
14 words
A medical device having an amphoteric hydrogel component according to claim 1 or 8.
Claim 12
Dependent Claim
14 words
The medical device of claim 9 wherein the medical device is a medical electrode.
Claim 13
Dependent Claim
14 words
The medical device of claim 10 wherein the medical electrode is an iontophoresis electrode.
Claim 14
Dependent Claim
14 words
The medical device of claim 10 wherein the medical electrode is a sensing electrode.
Claim 15
Dependent Claim
14 words
The medical device of claim 10 wherein the medical electrode is a stimulation electrode.
Claim 16
Dependent Claim
14 words
The medical device of claim 9 wherein the medical device is a wound dressing.
Claim 17
Dependent Claim
16 words
The medical device of claim 9 wherein the medical device is a passive drug delivery device.
Claim 18
Dependent Claim
13 words
The medical device of claim 9 wherein the hydrogel also comprises a drug.
Claim 19
Independent Claim
103 words
A method for making a medical device having an amphoteric, hydrophilic hydrogel for attachment to human skin comprising the steps of: a. dissolving a first monomeric constituent having an acid group in water; b. dissolving a second monomeric constituent having a base group in water, at least one of said first and second monomeric constituents being an N-substituted acrylamide and at least one of said acid group and said base group having a strongly ionic character, c. combining the first and second dissolved monomeric constituents; d. copolymerizing the combined first and second monomeric constituents; and e. applying the copolymer to a medical device.
Claim 20
Independent Claim
103 words
A method for making a medical device having an amphoteric, hydrophilic hydrogel for attachment to human skin comprising the steps of: a. dissolving a first monomeric constituent having an acid group in water; b. dissolving a second monomeric constituent having a base group in water, at least one of said first and second monomeric constituents being an N-substituted acrylamide and at least one of said acid group and said base group having a strongly ionic character, c. combining the first and second dissolved monomeric constituents; d. copolymerizing the combined first and second monomeric constituents; and e. applying the copolymer to a medical device.
Claim 21
Dependent Claim
13 words
The method of claim 17 wherein the first monomeric constituent is 2-acrylamido-2-methylpropanesulfonic acid.
Claim 22
Dependent Claim
27 words
The method of claim 17 also comprising the steps of: adding an ultraviolet catalyst in combination with the first and second monomeric constituents; and applying ultraviolet light.
Claim 23
Dependent Claim
15 words
The method of claim 17 wherein a crosslinking agent is included with the monomeric constituents.
Claim 24
Dependent Claim
12 words
The amphoteric hydrogel of claim 1 or 8 also comprising a drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-11 | 1999-12-11 | 2000-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-11 | 2003-12-11 | 2004-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-11 | 2007-12-11 | 2008-06-11 | $7700.00 | Window Closed / Lapsed |