Patent US4407387A successfully refreshed from Google Patents.
US4842597A
Expired / Lapsed
US
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Hydrophilic copolymers for wound dressings and other biomedical uses
Assignee: YARSLEY TECHNICAL CENTRE
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Filing: 1987-05-15
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Granted: 1989-06-27
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Expires: 2007-05-15
Abstract
Abstract A hydrophilic article is disclosed which is a layer of a non-cross-linked copolymer of a hydrophobic monomer component and a hydrophilic monomer component. Preferred hydrophobic monomers are lower alkyl esters of methacrylic and acrylic acids and preferred hydrophilic monomers are vinyl pyrrolidone and hydroxy ethyl methacrylates. The hydrophilic articles of the invention are useful in biomedical applications, especially in wound dressings and as coatings on catheters.
Inventors
- 👤 Michael G. Brook
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:12
CPC Classifications
C; C08; C08F; C08F220/00; C08F220/02; C08F220/10; C08F220/12; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/24; A61L15/42; A61L15/60; A61L26/00; A61L26/0009; A61L26/0014; A61L26/0061; A61L26/008; A61L29/00; A61L29/08; A61L29/085; A61L33/00; A61L33/06; A61L33/064
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
92 words
A wound dressing comprising a hydrogel layer having a water content of at least 50% by weight, said hydrogel consisting essentially of a water-swollen, substantially uncross-linked hydrophilic copolymer of a hydrophobic monomer component and a hydrophilic monomer component, wherein the hydrophobic monomer component comprises a lower alkyl acrylate or methacrylate ester and the hydrophilic monomer component is selected from N-vinyl pyrrolidone (NVP), and mixtures of NVP and one or more hydroxy alkyl acrylate and methacrylate, the hydrophobic and hydrophilic monomer components being copolymerized in the molar ratio of from 1:1 to 1:4.
Claim 2
Dependent Claim
92 words
A wound dressing comprising a hydrogel layer having a water content of at least 50% by weight, said hydrogel consisting essentially of a water-swollen, substantially uncross-linked hydrophilic copolymer of a hydrophobic monomer component and a hydrophilic monomer component, wherein the hydrophobic monomer component comprises a lower alkyl acrylate or methacrylate ester and the hydrophilic monomer component is selected from N-vinyl pyrrolidone (NVP), and mixtures of NVP and one or more hydroxy alkyl acrylate and methacrylate, the hydrophobic and hydrophilic monomer components being copolymerized in the molar ratio of from 1:1 to 1:4.
Claim 3
Dependent Claim
23 words
A wound dressing according to claim 1 in which the copolymer is capable of absorbing at least about 200% by weight of water.
Claim 4
Dependent Claim
24 words
A wound dressing according to claim 1 which includes a protective film covering the hydrogel layer, said film being strippable from the hydrogel layer.
Claim 5
Dependent Claim
36 words
A wound dressing according to claim 1 in which the copolymer is prepared by subjecting the monomers to non-aqueous dispersion polymerization in the presence of a graft dispersant precursor which stabilizes the dispersion of polymer particles.
Claim 6
Dependent Claim
24 words
A wound dressing according to claim 1 in which the hydrogel layer includes a chemotherapeutic substance dissolved in the aqueous compound of the hydrogel.
Claim 7
Dependent Claim
27 words
A wound dressing according to claim 1 wherein the hydrophobic component is methyl methacrylate and the hydrophilic component is vinyl pyrrolidone with or without hydroxy ethyl methacrylate.
Claim 8
Dependent Claim
24 words
A wound dressing according to claim 1 and in which the copolymer is capable of absorbing at least about 180% by weight of water.
Claim 9
Dependent Claim
30 words
A wound dressing according to claim 1 wherein the copolymer is prepared by copolymerising methyl methacrylate and vinyl pyrrolidone in the molar proportions of from about 1:1 to about 1:4.
Claim 10
Dependent Claim
20 words
A wound dressing according to claim 1 in which the hydrogel layer is supported by a reinforcing film or fabric.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-26 | 1992-12-26 | 1993-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-26 | 1996-12-26 | 1997-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-26 | 2000-12-26 | 2001-06-27 | $7700.00 | Window Closed / Lapsed |