Patent US5525331A successfully refreshed from Google Patents.
US5525331A
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Inhibitors of esterase-producing micro-organisms, for use primarily in deodorant compositions
Assignee: Robertet SA
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Filing: 1995-01-30
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Granted: 1996-06-11
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Expires: 2015-01-30
Abstract
Abstract Inhibitors of esterase-producing micro-organisms, primarily for use in dermatology and cosmetics and with particular application to personal deodorants and to anti-fungal agents and other preparations for the treatment of acne, dandruff and tinea pedis. The active ingredient of the inhibitor comprises an aromatic acid ester of a phenol or of an aromatic alcohol, the phenol or aromatic alcohol being sufficiently water-soluble to impart an anti-microbial action and the aromatic acid being sufficiently water-soluble to impart an anti-microbial action and/or to lower the pH of liquid body-secretions to a level which at least inhibits the growth of micro-organisms in the liquid body-secretions.
Inventors
- 👤 John A. Betts
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:47
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61Q; A61Q15/00; A61Q19/00; A61Q5/00; A61Q5/006; A61K2800/00; A61K2800/74; A61K2800/78; A61K2800/782
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
97 words
A deodorant composition for inhibiting esterase-producing micro-organisms comprising an active ingredient, a perfume composition that incorporates a percentage of the active ingredient, and a vehicle for carrying the perfume composition and the active ingredient, wherein the active ingredient is an aromatic acid ester of a phenol, wherein the phenol is sufficiently water-soluble to impart anti-microbial action, and wherein the aromatic acid is sufficiently water-soluble to impart, when dissolved in a liquid human body-secretion, an anti-microbial action and to lower the pH of the liquid body-secretion to a level which inhibits growth of micro-organisms in the liquid body-secretions.
Claim 2
Dependent Claim
97 words
A deodorant composition for inhibiting esterase-producing micro-organisms comprising an active ingredient, a perfume composition that incorporates a percentage of the active ingredient, and a vehicle for carrying the perfume composition and the active ingredient, wherein the active ingredient is an aromatic acid ester of a phenol, wherein the phenol is sufficiently water-soluble to impart anti-microbial action, and wherein the aromatic acid is sufficiently water-soluble to impart, when dissolved in a liquid human body-secretion, an anti-microbial action and to lower the pH of the liquid body-secretion to a level which inhibits growth of micro-organisms in the liquid body-secretions.
Claim 3
Dependent Claim
49 words
A deodorant composition as claimed in claim 1, wherein said phenol is selected from the group consisting of phenol, cresols, xylenols, thymol, carvacrol, eugenol and isoeugenol, and wherein said aromatic acid is selected from the group consisting of benzoic acid, salicylic acid, cinnamic acid, phenyl-acetic acid and anisic acid.
Claim 4
Dependent Claim
18 words
A composition as claimed in claim 1, wherein said active ingredient comprises phenol ester or aromatic alcohol ester.
Claim 5
Dependent Claim
34 words
A composition as claimed in claim 1, wherein 5%-50% of said active ingredient is incorporated in said perfume composition and approximately 1% of the perfume composition is added to an approximately 96% ethanol excipient.
Claim 6
Dependent Claim
13 words
A composition as claimed in claim 1, wherein said vehicle comprises an alcohol.
Claim 7
Dependent Claim
29 words
A composition as claimed in claim 1, wherein said active ingredient is incorporated in a vehicle which comprises aqueous alcohol and/or skin penetrants to produce also a dermatological action.
Claim 8
Dependent Claim
12 words
A composition as claimed in claim 6, and further incorporating anti-inflammatory substances.
Claim 9
Dependent Claim
9 words
The composition of claim 6, further incorporating healing agents.
Claim 10
Dependent Claim
9 words
The composition of claim 7, further incorporating healing agents.
Claim 11
Dependent Claim
11 words
The deodorant composition of claim 1, wherein the vehicle is ethanol.
Claim 12
Dependent Claim
23 words
The deodorant composition of claim 1, wherein the vehicle has a skin penetrant selected from the group consisting of polyol and dimethyl sulfoxide.
Claim 13
Dependent Claim
19 words
The deodorant composition of claim 1, wherein the vehicle is a mixture of dimethyl sulphoxide, polyol, ethanol and water.
Claim 14
Dependent Claim
20 words
The deodorant composition of claim 12, wherein between 0.5% to 20% of the active ingredient is incorporated into the vehicle.
Claim 15
Dependent Claim
20 words
The deodorant composition of claim 1, further comprising anti-inflammatory substances selected from the group consisting of hydrocortisone and glycyrrhetic acid.
Claim 16
Dependent Claim
13 words
The deodorant composition of claim 1, further comprising healing agents such as allantoin.
Claim 17
Dependent Claim
18 words
The deodorant composition of claim 1, wherein the vehicle is a hydro-alcoholic vehicle, and further comprising solubilising agents.
Claim 18
Dependent Claim
26 words
The deodorant composition of claim 1, wherein the composition is in a form selected from the group consisting of ointments, gels, creams, lotions, sprays and powders.
Claim 19
Dependent Claim
12 words
The deodorant composition of claim 1, wherein the vehicle is a powder.
Claim 20
Dependent Claim
23 words
The deodorant composition of claim 18, wherein the powder is selected from the group consisting of amorphous silica powder and light magnesium carbonate.
Claim 21
Dependent Claim
27 words
The deodorant composition of claim 1, wherein the vehicle is a mixture of light magnesium carbonate and powder selected from the group consisting of starch and talcum.
Claim 22
Dependent Claim
76 words
A composition for topical application to skin which inhibits esterase-producing micro-organisms to provide a deodorant effect, comprising: (a) a predeterminated amount of an aromatic ester of a phenol, the phenol being sufficiently water-soluble to import an anti-microbial action and the aromatic acid being sufficiently water-soluble to import an anti-microbial action and to lower pH of liquid body-secretions to a level which at least inhibits growth of micro-organisms in the liquid body-secretions; and (a) a pharmaceutically-acceptable carrier.
Claim 23
Dependent Claim
76 words
A composition for topical application to skin which inhibits esterase-producing micro-organisms to provide a deodorant effect, comprising: (a) a predeterminated amount of an aromatic ester of a phenol, the phenol being sufficiently water-soluble to import an anti-microbial action and the aromatic acid being sufficiently water-soluble to import an anti-microbial action and to lower pH of liquid body-secretions to a level which at least inhibits growth of micro-organisms in the liquid body-secretions; and (a) a pharmaceutically-acceptable carrier.
Claim 24
Independent Claim
113 words
A method for inhibiting the growth of esterase-producing micro-organisms on a skin surface of a human body comprising the step of applying to said skin surface a liquid composition containing a growth-inhibiting amount of an ester of (a) an aromatic acid and (b) a phenol, whereby esterase produced by the micro-organisms partially hydrolyses the ester into its acid and phenol components which are sufficiently soluble in liquid secretions located of the skin surface to inhibit further growth of the micro-organisms for a period of time by imparting an anti-microbial action and lowering pH of the liquid body-secretions, after which repeated hydrolysis and inhibition takes place until all of the ester is used up.
Claim 25
Independent Claim
113 words
A method for inhibiting the growth of esterase-producing micro-organisms on a skin surface of a human body comprising the step of applying to said skin surface a liquid composition containing a growth-inhibiting amount of an ester of (a) an aromatic acid and (b) a phenol, whereby esterase produced by the micro-organisms partially hydrolyses the ester into its acid and phenol components which are sufficiently soluble in liquid secretions located of the skin surface to inhibit further growth of the micro-organisms for a period of time by imparting an anti-microbial action and lowering pH of the liquid body-secretions, after which repeated hydrolysis and inhibition takes place until all of the ester is used up.
Claim 26
Dependent Claim
45 words
The method according to claim 22, wherein the phenol is selected from the group consisting of phenol, cresols, xylenols, thymol, carvacrol, eugenol and isoeugenol and the acid is selected from the group consisting of benzoic acid, salicylic acid, cinnamic acid, phenylacetic acid and anisic acid.
Claim 27
Dependent Claim
19 words
The method of claim 22, wherein applying the inhibiting composition further comprises incorporating an active ingredient in a vehicle.
Claim 28
Dependent Claim
28 words
The method of claim 24, wherein applying the inhibiting composition further comprises incorporating the active ingredient in a perfume composition and incorporating the perfume composition in the vehicle.
Claim 29
Dependent Claim
19 words
The method of claim 22, wherein applying the inhibiting composition further comprises spraying the composition on the skin surface.
Claim 30
Dependent Claim
29 words
The method of claim 22, wherein applying the inhibiting composition further comprises introducing droplets of the composition on the skin surface and massaging the composition in the skin surface.
Claim 31
Dependent Claim
29 words
The method of claim 22, further comprising pre-impregnating a pad with the inhibiting composition, and wherein applying the inhibiting composition further comprises contacting the skin surface with the pad.
Claim 32
Dependent Claim
42 words
The method of claim 22, wherein applying the inhibiting composition further comprises adsorbing an active ingredient on an amorphous silica powder and mixing the active ingredient and amorphous silica powder with 50% powder selected from a group consisting of talc and starch.
Claim 33
Dependent Claim
41 words
The method of claim 22, wherein applying the inhibiting composition further comprises adsorbing an active ingredient on light magnesium carbonate and mixing the active ingredient and light magnesium carbonate with 50% powder selected from a group consisting of talc and starch.
Claim 34
Dependent Claim
25 words
The method of claim 22, wherein applying the inhibiting composition further comprises grinding an active ingredient and mixing a ground active ingredient with a powder.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-06-11 | 1999-12-11 | 2000-06-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-06-11 | 2003-12-11 | 2004-06-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-06-11 | 2007-12-11 | 2008-06-11 | $7700.00 | Window Closed / Lapsed |