US4199576A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Analgesic and anti-inflammatory compositions for topical application
Assignee: Procter and Gamble Co
•
Filing: 1979-01-10
•
Granted: 1980-04-22
•
Expires: 1999-01-10
Abstract
Abstract Compositions containing salicylic acid derivatives are useful for topical application to the skin. The compositions are especially effective for providing an anti-inflammatory effect.
Inventors
- 👤 Herbert H. Reller
- 👤 Herbert C. Kretschmar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:13
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61K31/00; A61K31/60; A61Q; A61Q19/00
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
120 words
A composition for topical application to skin to alleviate inflammation, consisting essentially of: (a) an effective amount of a salicylic acid derivative of the formula ##STR3## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl; and (b) the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative, said carrier being capable of delivering the salicylic acid derivative to the skin and capable of resisting removal by water for a length of time sufficient for the salicylic acid derivative to penetrate into the skin.
Claim 2
Dependent Claim
120 words
A composition for topical application to skin to alleviate inflammation, consisting essentially of: (a) an effective amount of a salicylic acid derivative of the formula ##STR3## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl; and (b) the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative, said carrier being capable of delivering the salicylic acid derivative to the skin and capable of resisting removal by water for a length of time sufficient for the salicylic acid derivative to penetrate into the skin.
Claim 3
Dependent Claim
20 words
The composition of claim 1 wherein the composition consists essentially of from 0.001% to 10% of the salicylic acid derivative.
Claim 4
Dependent Claim
9 words
The composition of claim 2 wherein X is 0.
Claim 5
Dependent Claim
12 words
The composition of claim 3 wherein R 2 is an alkyl group.
Claim 6
Dependent Claim
12 words
The composition of claim 3 wherein R 2 is an alkenyl group.
Claim 7
Dependent Claim
10 words
The composition of claim 3 wherein R 2 is benzyl.
Claim 8
Dependent Claim
10 words
The composition of claim 3 wherein R 2 is phenyl.
Claim 9
Dependent Claim
13 words
The composition of claim 2 wherein X is NH or NR 2 .
Claim 10
Dependent Claim
13 words
The composition of claim 4 wherein the salicylic acid derivative is hexyl 2-acetoxybenzoate.
Claim 11
Dependent Claim
13 words
The composition of claim 6 wherein the salicylic acid derivative is benzyl 2-acetoxybenzoate.
Claim 12
Dependent Claim
36 words
The composition of claim 2 wherein the composition is in the form of a lotion consisting essentially of: (a) the salicylic acid derivative; (b) from 1% to 25% of an emollient; and (c) the balance water.
Claim 13
Dependent Claim
16 words
The composition of claim 11 further consisting essentially of from 1% to 10% of an emulsifier.
Claim 14
Dependent Claim
36 words
The composition of claim 2 wherein the composition is in the form of a cream consisting essentially of: (a) the salicylic acid derivative; (b) from 5% to 50% of an emollient; and (c) the balance water.
Claim 15
Dependent Claim
16 words
The composition of claim 13 further consisting essentially of from 3% to 50% of an emulsifier.
Claim 16
Dependent Claim
29 words
The composition of claim 2 wherein the composition in the form of a solution consisting essentially of: (a) the salicylic acid derivative; and (b) the balance an organic solvent.
Claim 17
Dependent Claim
46 words
The composition of claim 2 wherein the composition is in the form of a gel consisting essentially of: (a) the salicylic acid derivative; (b) from 5% to 75% of an organic solvent; (c) from 0.5% to 20% of a thickening agent; and (d) the balance water.
Claim 18
Dependent Claim
32 words
The composition of claim 2 wherein the composition is in the form of a solid consisting essentially of: (a) the salicylic acid derivative; and (b) from 50% to 98% of an emollient.
Claim 19
Independent Claim
66 words
A method of topically alleviating inflammation, comprising applying to the epidermal area so affected an effective amount of a salicylic acid derivative of formula ##STR4## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl.
Claim 20
Independent Claim
66 words
A method of topically alleviating inflammation, comprising applying to the epidermal area so affected an effective amount of a salicylic acid derivative of formula ##STR4## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl.
Claim 21
Dependent Claim
42 words
The method of claim 18 wherein a composition consisting essentially of from 0.001% to 10% of the salicylic acid derivative and the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative is applied to the epidermal area.
Claim 22
Dependent Claim
25 words
The method of claim 19 wherein from 0.01 μg to 500 μg of the salicylic acid derivative is applied per square centimeter of epidermal area.
Claim 23
Dependent Claim
9 words
The method of claim 20 wherein X is 0.
Claim 24
Dependent Claim
12 words
The method of claim 21 wherein R 2 is an alkyl group.
Claim 25
Dependent Claim
12 words
The method of claim 21 wherein R 2 is an alkenyl group.
Claim 26
Dependent Claim
10 words
The method of claim 21 wherein R 2 is benzyl.
Claim 27
Dependent Claim
10 words
The method of claim 21 wherein R 2 is phenyl.
Claim 28
Dependent Claim
13 words
The method of claim 20 where X is NH or NR 2 .
Claim 29
Dependent Claim
13 words
The method of claim 22 wherein the salicylic acid derivative is hexyl 2-acetoxybenzoate.
Claim 30
Dependent Claim
13 words
The method of claim 24 wherein the salicylic acid derivative is benzyl 2-acetoxybenzoate.
Claim 31
Dependent Claim
29 words
The method of claim 20 wherein inflammation of skin is treated with from 0.01 μg to 50 μg of the salicylic acid derivative per square centimeter of epidermal area.
Claim 32
Dependent Claim
33 words
The method of claim 20 wherein inflammation of muscles, tendons, bursa or joints is treated with from 0.1 μg to 500 μg of the salicylic acid derivative per square centimeter of epidermal area.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-22 | 1983-10-22 | 1984-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-22 | 1987-10-22 | 1988-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-22 | 1991-10-22 | 1992-04-22 | $7700.00 | Window Closed / Lapsed |