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US4199576A Expired / Lapsed US ⏱️ 0.0 years remaining

Analgesic and anti-inflammatory compositions for topical application

Assignee: Procter and Gamble Co
•
Filing: 1979-01-10
•
Granted: 1980-04-22
•
Expires: 1999-01-10
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Abstract

Abstract Compositions containing salicylic acid derivatives are useful for topical application to the skin. The compositions are especially effective for providing an anti-inflammatory effect.

Inventors

  • 👤 Herbert H. Reller
  • 👤 Herbert C. Kretschmar

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-09 03:28
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/37; A61K31/00; A61K31/60; A61Q; A61Q19/00

Claims Analysis

Total Claims: 32
Claim 1
Independent Claim 120 words
A composition for topical application to skin to alleviate inflammation, consisting essentially of: (a) an effective amount of a salicylic acid derivative of the formula ##STR3## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl; and (b) the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative, said carrier being capable of delivering the salicylic acid derivative to the skin and capable of resisting removal by water for a length of time sufficient for the salicylic acid derivative to penetrate into the skin.
Claim 2
Dependent Claim 120 words
A composition for topical application to skin to alleviate inflammation, consisting essentially of: (a) an effective amount of a salicylic acid derivative of the formula ##STR3## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl; and (b) the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative, said carrier being capable of delivering the salicylic acid derivative to the skin and capable of resisting removal by water for a length of time sufficient for the salicylic acid derivative to penetrate into the skin.
Claim 3
Dependent Claim 20 words
The composition of claim 1 wherein the composition consists essentially of from 0.001% to 10% of the salicylic acid derivative.
Claim 4
Dependent Claim 9 words
The composition of claim 2 wherein X is 0.
Claim 5
Dependent Claim 12 words
The composition of claim 3 wherein R 2 is an alkyl group.
Claim 6
Dependent Claim 12 words
The composition of claim 3 wherein R 2 is an alkenyl group.
Claim 7
Dependent Claim 10 words
The composition of claim 3 wherein R 2 is benzyl.
Claim 8
Dependent Claim 10 words
The composition of claim 3 wherein R 2 is phenyl.
Claim 9
Dependent Claim 13 words
The composition of claim 2 wherein X is NH or NR 2 .
Claim 10
Dependent Claim 13 words
The composition of claim 4 wherein the salicylic acid derivative is hexyl 2-acetoxybenzoate.
Claim 11
Dependent Claim 13 words
The composition of claim 6 wherein the salicylic acid derivative is benzyl 2-acetoxybenzoate.
Claim 12
Dependent Claim 36 words
The composition of claim 2 wherein the composition is in the form of a lotion consisting essentially of: (a) the salicylic acid derivative; (b) from 1% to 25% of an emollient; and (c) the balance water.
Claim 13
Dependent Claim 16 words
The composition of claim 11 further consisting essentially of from 1% to 10% of an emulsifier.
Claim 14
Dependent Claim 36 words
The composition of claim 2 wherein the composition is in the form of a cream consisting essentially of: (a) the salicylic acid derivative; (b) from 5% to 50% of an emollient; and (c) the balance water.
Claim 15
Dependent Claim 16 words
The composition of claim 13 further consisting essentially of from 3% to 50% of an emulsifier.
Claim 16
Dependent Claim 29 words
The composition of claim 2 wherein the composition in the form of a solution consisting essentially of: (a) the salicylic acid derivative; and (b) the balance an organic solvent.
Claim 17
Dependent Claim 46 words
The composition of claim 2 wherein the composition is in the form of a gel consisting essentially of: (a) the salicylic acid derivative; (b) from 5% to 75% of an organic solvent; (c) from 0.5% to 20% of a thickening agent; and (d) the balance water.
Claim 18
Dependent Claim 32 words
The composition of claim 2 wherein the composition is in the form of a solid consisting essentially of: (a) the salicylic acid derivative; and (b) from 50% to 98% of an emollient.
Claim 19
Independent Claim 66 words
A method of topically alleviating inflammation, comprising applying to the epidermal area so affected an effective amount of a salicylic acid derivative of formula ##STR4## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl.
Claim 20
Independent Claim 66 words
A method of topically alleviating inflammation, comprising applying to the epidermal area so affected an effective amount of a salicylic acid derivative of formula ##STR4## where R 1 is an alkyl group having from 1 to 4 carbon atoms, X is O, NH or NR 2 and R 2 is a saturated or unsaturated aliphatic group having from 4 to 10 carbon atoms, benzyl or phenyl.
Claim 21
Dependent Claim 42 words
The method of claim 18 wherein a composition consisting essentially of from 0.001% to 10% of the salicylic acid derivative and the balance a pharmaceutically acceptable carrier having dissolved or dispersed therein the salicylic acid derivative is applied to the epidermal area.
Claim 22
Dependent Claim 25 words
The method of claim 19 wherein from 0.01 μg to 500 μg of the salicylic acid derivative is applied per square centimeter of epidermal area.
Claim 23
Dependent Claim 9 words
The method of claim 20 wherein X is 0.
Claim 24
Dependent Claim 12 words
The method of claim 21 wherein R 2 is an alkyl group.
Claim 25
Dependent Claim 12 words
The method of claim 21 wherein R 2 is an alkenyl group.
Claim 26
Dependent Claim 10 words
The method of claim 21 wherein R 2 is benzyl.
Claim 27
Dependent Claim 10 words
The method of claim 21 wherein R 2 is phenyl.
Claim 28
Dependent Claim 13 words
The method of claim 20 where X is NH or NR 2 .
Claim 29
Dependent Claim 13 words
The method of claim 22 wherein the salicylic acid derivative is hexyl 2-acetoxybenzoate.
Claim 30
Dependent Claim 13 words
The method of claim 24 wherein the salicylic acid derivative is benzyl 2-acetoxybenzoate.
Claim 31
Dependent Claim 29 words
The method of claim 20 wherein inflammation of skin is treated with from 0.01 μg to 50 μg of the salicylic acid derivative per square centimeter of epidermal area.
Claim 32
Dependent Claim 33 words
The method of claim 20 wherein inflammation of muscles, tendons, bursa or joints is treated with from 0.1 μg to 500 μg of the salicylic acid derivative per square centimeter of epidermal area.

References Cited (Backward Citations)

US749980A Cited
US706356A Cited
US1436304A Cited
US2474005A Cited
US2975097A Cited
US3119739A Cited
US3518297A Cited
GB1220447A Cited
GB1379009A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-04-22 1983-10-22 1984-04-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-04-22 1987-10-22 1988-04-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-04-22 1991-10-22 1992-04-22 $7700.00 Window Closed / Lapsed

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