US5516807A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for treating vascular proliferative disorders following balloon angioplasty
Assignee: Warner Lambert Co LLC
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Filing: 1994-10-25
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Granted: 1996-05-14
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Expires: 2014-10-25
Abstract
Abstract Polyamines inhibit vascular smooth muscle proliferation and thus are useful in treating and preventing vascular proliferative disorders such as restenosis following balloon angioplasty.
Inventors
- 👤 Donald Hupe
- 👤 Joan A. Keiser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 10:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61P; A61P43/00; A61P9/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
115 words
A method for treating or preventing restenosis following balloon angioplasty, restenosis following graft or shunt implantation, or restenosis following atherectomy comprising administering to a subject in need of treatment or prevention an effective amount of a polyamine of the formula ##STR4## wherein: R 1 and R 6 independently are hydrogen or C 1 -C 12 alkyl; R 2 , R 3 , R 4 , and R 5 independently are hydrogen or C 1 -C 12 alkyl; m and n are integers from 3 to 6; or a pharmaceutically acceptable salt thereof, provided at least one of R 1 , R 2 , R 5 , and R 6 is C 1 -C 12 alkyl.
Claim 2
Independent Claim
115 words
A method for treating or preventing restenosis following balloon angioplasty, restenosis following graft or shunt implantation, or restenosis following atherectomy comprising administering to a subject in need of treatment or prevention an effective amount of a polyamine of the formula ##STR4## wherein: R 1 and R 6 independently are hydrogen or C 1 -C 12 alkyl; R 2 , R 3 , R 4 , and R 5 independently are hydrogen or C 1 -C 12 alkyl; m and n are integers from 3 to 6; or a pharmaceutically acceptable salt thereof, provided at least one of R 1 , R 2 , R 5 , and R 6 is C 1 -C 12 alkyl.
Claim 3
Dependent Claim
18 words
A method according to claim 1 wherein the condition being prevented or treated is restenosis following balloon angioplasty.
Claim 4
Dependent Claim
30 words
A method of claim 1 employing a compound wherein R 1 and R 6 both are C 1 -C 6 alkyl, and R 2 and R 5 both are hydrogen.
Claim 5
Dependent Claim
17 words
A method of claim 3 employing a compound wherein R 1 and R 6 both are ethyl.
Claim 6
Dependent Claim
12 words
A method of claim 4 employing a compound wherein m is 3.
Claim 7
Dependent Claim
12 words
A method of claim 5 employing a compound wherein n is 4.
Claim 8
Dependent Claim
12 words
A method of claim 5 employing a compound wherein n is 3.
Claim 9
Dependent Claim
16 words
A method of claim 4 employing a compound wherein m is 4 and n is 4.
Claim 10
Dependent Claim
21 words
A method of claim 1 wherein the condition being prevented or treated is vascular proliferative disorder following graft or shunt implantation.
Claim 11
Dependent Claim
18 words
A method of claim 1 wherein the condition being prevented or treated is vascular proliferative disorder following atherectomy.
References Cited (Backward Citations)
JPS52118405A
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US4507321A
Cited
JPS606348A
Cited
EP0162413A2
Cited
EP0277635A2
Cited
EP0349224A2
Cited
EP0399519A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-05-14 | 1999-11-13 | 2000-05-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-05-14 | 2003-11-13 | 2004-05-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-05-14 | 2007-11-13 | 2008-05-14 | $7700.00 | Window Closed / Lapsed |