EP0349224A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
Assignee: University of Florida
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Filing: 1989-06-23
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Granted: —
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Expires: 2009-06-23
Abstract
Abstract The present invention provides a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive, or (IV), a salt thereof especially for anti-neoplastic, anti-psoriasis, anti-viral or anti-retroviral therapy or for controlling the growth of insects.
Inventors
- 👤 Raymond J. Bergeron
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 10:55
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/04; A; A01; A01N; A01N33/00; A01N33/02; A01N33/04; A01N43/00; A01N43/48; A01N43/54; A61; A61K; A61K31/00; A61K31/13; A61K31/131; A61K31/135; A61K31/33; A61K31/395; A61K31/495; A61K31/505; A61K31/506; A61K31/74; A61K31/785; A61P; A61P17/00; A61P31/00; A61P31/04; A61P31/12; A61P33/00; A61P33/02; A61P33/06; A61P35/00; C07C; C07C209/00; C07C209/04; C07C209/06; C07C209/08; C07C209/62; C07C211/00; C07C211/01; C07C211/02; C07C211/14
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
107 words
A method of making a pharmaceutical composition comprising mixing an anti-neoplastic effective amount of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid; with a pharmaceutically acceptable carrier therefor.
Claim 2
Independent Claim
107 words
A method of making a pharmaceutical composition comprising mixing an anti-neoplastic effective amount of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid; with a pharmaceutically acceptable carrier therefor.
Claim 3
Dependent Claim
26 words
A method according to claim 1, wherein m is 3 and n is 4, or m and n are 3 or m and n are 4.
Claim 4
Dependent Claim
47 words
A method according to claim 1, wherein R₁ and R₆ are alkyl, or wherein R₁ and R₆ are aralkyl, or wherein R₁ and R₆ are methyl, or wherein R₁ and R₆ are ethyl, or wherein R₁ and R₆ are propyl, or wherein R₁ and R₆ are benzyl.
Claim 5
Dependent Claim
91 words
Use of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid in the manufacture of a medicament for anti-neoplastic therapy.
Claim 6
Dependent Claim
91 words
Use of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid in the manufacture of a medicament for anti-neoplastic therapy.
Claim 7
Dependent Claim
25 words
Use according to claim 4 wherein m is 3 and n is 4, or m and n are 3 or m and n are 4.
Claim 8
Dependent Claim
46 words
Use according to claim 4, wherein R₁ and R₆ are alkyl, or wherein R₁ and R₆ are aralkyl, or wherein R₁ and R₆ are methyl, or wherein R₁ and R₆ are ethyl, or wherein R₁ and R₆ are propyl, or wherein R₁ and R₆ are benzyl.
Claim 9
Independent Claim
110 words
A method of making a pharmaceutical composition comprising mixing an anti-viral, anti-psoriasis or anti-retroviral effective amount of a compound having one of the formula: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or, (IV), a salt thereof with a pharmaceutically acceptable acid; with a pharmaceutically acceptable carrier therefor.
Claim 10
Independent Claim
110 words
A method of making a pharmaceutical composition comprising mixing an anti-viral, anti-psoriasis or anti-retroviral effective amount of a compound having one of the formula: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6, inclusive; or, (IV), a salt thereof with a pharmaceutically acceptable acid; with a pharmaceutically acceptable carrier therefor.
Claim 11
Dependent Claim
95 words
Use of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid in the manufacture of a medicament for anti-neoplastic, anti-viral or anti-retroviral therapy.
Claim 12
Dependent Claim
95 words
Use of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with a pharmaceutically acceptable acid in the manufacture of a medicament for anti-neoplastic, anti-viral or anti-retroviral therapy.
Claim 13
Independent Claim
102 words
A method of making an insecticidal composition comprising mixing an insecticidably effective amount of a compound having one of the formula: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl, aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6 inclusive; or (IV), a salt thereof with an acid with a carrier therefor.
Claim 14
Independent Claim
102 words
A method of making an insecticidal composition comprising mixing an insecticidably effective amount of a compound having one of the formula: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms; R₂ - R₅ may be the same or different and are H, R₁ or R₆; R₇ is H, alkyl, aryl, aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; n is an integer from 3 to 6 inclusive; or (IV), a salt thereof with an acid with a carrier therefor.
Claim 15
Independent Claim
101 words
A method of controlling the growth of insects comprising administering to said insects an insecticidal effective amount of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with an acid and a carrier therefor.
Claim 16
Independent Claim
101 words
A method of controlling the growth of insects comprising administering to said insects an insecticidal effective amount of a compound having one of the formulae: Wherein: R₁ and R₆ may be the same or different and are H, alkyl or aralkyl having from 1 to 12 carbon atoms, provided that R₁ and R₆ are not H; R₇ is H, alkyl, aryl or aralkyl having from 1 to 12 carbon atoms; m is an integer from 3 to 6, inclusive; and n is an integer from 3 to 6, inclusive; or (IV), a salt thereof with an acid and a carrier therefor.
References Cited (Backward Citations)
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