EP0399519A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Potentiating cell-mediated immunity utilizing polyamine derivatives
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1990-05-23
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Granted: —
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Expires: 2010-05-23
Abstract
Abstract This invention relates to the use of a compound of the formula: RHN-Z-NH-(CH₂) m -NH-Z-NHR or a pharmaceutically acceptable salt thereof, wherein m is an integer 3 to 12, Z is a saturated C₂-C₆ alkylene moiety of straight or branched chain configuration, each R group is independently H, a C₁-C₆ saturated or unsaturated hydrocarbyl, or -(CH₂) x -(Ar)-X wherein X is H, C₁-C₆ alkoxy, halogen, C₁-C₄ alkyl, or -S(O) x R₁, x is an integer 0, 1 or 2, and R₁ is C₁-C₆ alkyl, for the preparation of a pharmaceutical composition useful for potentiating cell-mediated immunity.
Inventors
- 👤 Terry L. Bowlin
- 👤 Nellikunja Prakash
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 11:14
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61P; A61P31/00; A61P31/12; A61P35/00; A61P37/00; A61P37/02; A61P37/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
98 words
Use of a compound of the formula [I] RHN-Z-NH-(CH₂) m NH-Z-NHR [I] or a pharmaceutically acceptable salt thereof, wherein m is an integer 3 to 12, Z is a saturated C₂-C₆ alkylene moiety of straight or branched chain configuration, each R group is independently H, a C₁-C₆ saturated or unsaturated hydrocarbyl, or -(CH₂) x -(Ar)-X wherein Ar is phenyl or naphthyl, X is H, C₁-C₆ alkoxy, halogen, C₁-C₄ alkyl, or -S(O) x R₁, wherein x is an integer 0, 1, or 2, and R₁ is C₁-C₆ alkyl, for the preparation of a pharmaceutical composition for potentiating cell-mediated immunity.
Claim 2
Dependent Claim
98 words
Use of a compound of the formula [I] RHN-Z-NH-(CH₂) m NH-Z-NHR [I] or a pharmaceutically acceptable salt thereof, wherein m is an integer 3 to 12, Z is a saturated C₂-C₆ alkylene moiety of straight or branched chain configuration, each R group is independently H, a C₁-C₆ saturated or unsaturated hydrocarbyl, or -(CH₂) x -(Ar)-X wherein Ar is phenyl or naphthyl, X is H, C₁-C₆ alkoxy, halogen, C₁-C₄ alkyl, or -S(O) x R₁, wherein x is an integer 0, 1, or 2, and R₁ is C₁-C₆ alkyl, for the preparation of a pharmaceutical composition for potentiating cell-mediated immunity.
Claim 3
Dependent Claim
32 words
Use of a compound of the formula [I] as defined in claim 1 for the preparation of a pharmaceutical composition for potentiating the activity of effector cells of the cellular immune system.
Claim 4
Dependent Claim
13 words
Use according to claim 2 wherein the effector cell potentiated is a T-cell.
Claim 5
Dependent Claim
16 words
Use according to claim 2 wherein the effector cell potentiated is a natural cell-mediated cytotoxic cell.
Claim 6
Dependent Claim
13 words
Use according to claim 2 wherein the effector cell potentiated is a macrophage.
Claim 7
Dependent Claim
13 words
Use according to claim 1 or 2 wherein compound [I] is 3,7,15,19-tetraazaheneicosane tetrahydrochloride.
Claim 8
Dependent Claim
13 words
Use according to claim 1 or 2 wherein compound [I] is 2,17-dimethyl-2,6,14,18-tetraazanonadecane tetrahydrochloride.
Claim 9
Dependent Claim
13 words
Use according to claim 1 or 2 wherein compound [I] is 4,16-dimethyl-2,6,14,18-tetraazanonadecane tetrahydrochloride.
Claim 10
Dependent Claim
22 words
Use according to any one of claims 1 to 8, wherein said composition additionally comprises a pharmaceutically acceptable carrier, diluent or excipient.
References Cited (Backward Citations)
No citation records indexed.
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