EP0162413A2
Expired / Lapsed
EP
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Polyamine for use as a medicine in the treatment of neoplasms
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1985-05-15
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Granted: —
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Expires: 2005-05-15
Abstract
Abstract This invention relates to the use of certain polyamines in the treatment of neoplasms or in conjunctive therapy with ornithine decarboxylase inhibitors and/or S-adeno-sylme- thionine decarboxylase inhibitors or in conjunction with other known cytotoxic agents, or with interferon.
Inventors
- 👤 Nellikunja J. Prakash
- 👤 Sai P. Sunkara
- 👤 David M. Stemerick
- 👤 Michael L. Edwards
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-08 11:23
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/23; C07C323/24; C07C323/25; A; A61; A61K; A61K31/00; A61K31/13; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
138 words
Process for preparing a polyamine of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein X is -CH 2 -, NR, O, S, SO or S0 2 , R is hydrogen, (C 1 -C 6 )alkyl, benzyl, mono- or di-substituted benzyl wherein the substituent is selected from hydroxy, halogen, (C 1 -C 4 )alkyl and (C 3 -C 4 )alkoxy, R 1 and R 3 each are independently (C 1 -C 6 ) alkyl, hydrogen or - (CH 2 ) 3 NH 2 R 2 and R 4 are (C 1 -C 6 alkyl or hydrogen, A is a (C 3 -C 4 )alkylene, optionally substituted with a (C 1 -C 4 )alkyl, and B is a (C 2 -C 4 )alkylene, optionally substituted with a (C 1 -C 4 )alkyl, for use as a medicine.
Claim 2
Dependent Claim
138 words
Process for preparing a polyamine of the formula and the pharmaceutically acceptable acid addition salts thereof, wherein X is -CH 2 -, NR, O, S, SO or S0 2 , R is hydrogen, (C 1 -C 6 )alkyl, benzyl, mono- or di-substituted benzyl wherein the substituent is selected from hydroxy, halogen, (C 1 -C 4 )alkyl and (C 3 -C 4 )alkoxy, R 1 and R 3 each are independently (C 1 -C 6 ) alkyl, hydrogen or - (CH 2 ) 3 NH 2 R 2 and R 4 are (C 1 -C 6 alkyl or hydrogen, A is a (C 3 -C 4 )alkylene, optionally substituted with a (C 1 -C 4 )alkyl, and B is a (C 2 -C 4 )alkylene, optionally substituted with a (C 1 -C 4 )alkyl, for use as a medicine.
Claim 3
Dependent Claim
17 words
Process according to claim 1 for preparing a polyamine which is N,N'-bis(3-aminopropyl)-1,8-octanediamine for use as a medicine.
Claim 4
Dependent Claim
53 words
3 . Process for preparing a product containing a für Österrelch polyamine compound according to claim 1, and an pour l'Autriche ornithine dicarboxylase inhibitor and/or a S-adenosylmethionine dicarboxylase inhibitor and optionally in the presence of interferon and/or a cytotoxic agent as a combined preparation for simultaneous, separate or sequential use as a medicine.
Claim 5
Dependent Claim
41 words
Process according to claim 3 for preparing a product containing a polyamine compound according to claim 1, or 2 an ornithine decarboxylase inhibitor, interferon and a cytotoxic agent as a combined preparation for simultaneous, separate or sequential use as a medicine.
Claim 6
Dependent Claim
31 words
Process according to claim 1 or 3 for preparing a compound according to claim 1, or 2 or a polyamine compound in a product according to claim 3 which is norspermidine.
Claim 7
Dependent Claim
36 words
Process according to claim 3 for preparing a product wherein the ornithine decarboxylase inhibitor is selected from the group consisting of α-difluoromethyl ornithine, αmonofluoromethyl ornithine, (2R, 5R)-6-heptyn-2,5-diamine, and the methyl or ethyl ester of monofluoromethyl dehydrornithine.
Claim 8
Dependent Claim
17 words
Process according to claim 3 for preparing a product wherein the ornithine decarboxylase inhibitor is α-difluoromethyl ornithine.
Claim 9
Dependent Claim
30 words
Process for preparing a compound according to claim 1 or 2 or a product according to claim 3 for the manufacture of a medicament for the treatment of neoplastic diseases.
Claim 10
Dependent Claim
41 words
Process for preparing a compound of claim 1 or 2 or a product according to claim 3, for the manufacture of a medicament for the treatment of neoplastic diseases wherein the neoplastic disease consists of leukemia, melanoma, carcinoma, sarcoma, and lymphoma.
Claim 11
Dependent Claim
35 words
Process for preparing a pharmaceutical composition for use in the treatment of neoplastic diseases which includes a compound of claim 1, 2 or a product of claim 3 in admixture with a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
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