US5507804A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
Assignee: Alcon Vision LLC
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Filing: 1994-11-16
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Granted: 1996-04-16
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Expires: 2014-11-16
Abstract
Abstract Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized end-capped PEO which is attached at one end to the medical device. The PEO compounds are then exposed to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network. These PEO coatings are able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
Inventors
- 👤 Gerard Llanos
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 19:49
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/08; A61L29/085; A61L2/00; A61L2/16; A61L2/20; A61L2/206; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/06; A61L33/068
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
76 words
A PEO-coated implantable medical device which can be sterilized by ethylene oxide sterilization without substantial loss of the PEO coating's protein and/or cell repulsion ability, wherein the device comprises a PEO coating comprising cross-linked, α,ω-aldehyde-terminated PEO compounds having a number average molecular weight from 200-100,000, and wherein at least one of the α,ω-aldehydes of the PEO compounds is attached to the implantable medical device and the cross-linking is achieved by exposure to a high energy source.
Claim 2
Dependent Claim
76 words
A PEO-coated implantable medical device which can be sterilized by ethylene oxide sterilization without substantial loss of the PEO coating's protein and/or cell repulsion ability, wherein the device comprises a PEO coating comprising cross-linked, α,ω-aldehyde-terminated PEO compounds having a number average molecular weight from 200-100,000, and wherein at least one of the α,ω-aldehydes of the PEO compounds is attached to the implantable medical device and the cross-linking is achieved by exposure to a high energy source.
Claim 3
Dependent Claim
16 words
The medical device of claim 1 wherein the α,ω-aldehyde-terminated PEO has a molecular weight from 1,500-10,000.
Claim 4
Dependent Claim
17 words
The medical device of claim 2 wherein the α,ω-aldehyde-terminated PEO has a molecular weight of about 8000.
Claim 5
Dependent Claim
45 words
The medical device of claim 1 wherein the high energy source is a source which results in the formation of one or more of the group consisting of free radicals, ions, electrons, protons, neutrons, alpha particles, beta particles, gamma radiation, X-ray radiation, and ultraviolet radiation.
Claim 6
Dependent Claim
15 words
The medical device of claim 4 wherein the high energy source is an argon plasma.
Claim 7
Dependent Claim
14 words
The medical device of claim 1 wherein the medical device is an intraocular lens.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-04-16 | 1999-10-16 | 2000-04-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-04-16 | 2003-10-16 | 2004-04-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-04-16 | 2007-10-16 | 2008-04-16 | $7700.00 | Window Closed / Lapsed |