US5497770A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tissue viability monitor
Assignee: University of California
•
Filing: 1994-01-14
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Granted: 1996-03-12
•
Expires: 2014-01-14
Abstract
Abstract A method and apparatus for evaluating the viability of a tissue of interest, particularly that presents as dead but may be merely stunned or hibernating with reduced or no contractility. Dynamic measurement of oxidative metabolism permits distinguishing between different stages of compromised myocardium. Measurements can be made using near-infrared illumination and detection coupled with infusion of one or more metabolic substrates to the region of interest to evaluate whether a metabolic pathway cascade or a trans-membrane ionic potential are intact and thereby provide an indication of the viability of the cell.
Inventors
- 👤 N. Charle Morcos
- 👤 Roger A. Nahas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 08:26
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/41; A61B5/413; A61B5/0059; A61B5/0075; A61B5/0082; A61B5/0084; A61B5/0086; A61N; A61N1/00; A61N1/02; A61N1/04; A61N1/05
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
37 words
A method of determining the viability of tissue comprising the steps of measuring a characteristic of an intracellular component, infusing a substrate compound and measuring the characteristic of the intracellular component after infusion of the substrate compound.
Claim 2
Independent Claim
37 words
A method of determining the viability of tissue comprising the steps of measuring a characteristic of an intracellular component, infusing a substrate compound and measuring the characteristic of the intracellular component after infusion of the substrate compound.
Claim 3
Dependent Claim
20 words
The method of claim 1 where the measuring steps comprise measuring a characteristic of an intracellular component of myocardial tissue.
Claim 4
Dependent Claim
25 words
The method of claim 1 where the measuring steps comprise measuring a characteristic of an intracellular component of contractile tissue which is stunned or hibernating.
Claim 5
Dependent Claim
25 words
The method of claim 1 where the measuring steps comprise measuring a characteristic of an intracellular component of contractile tissue with reduced or no contractility.
Claim 6
Dependent Claim
24 words
The method of claim 1 where the steps of measuring the characteristic of the intracellular component comprise measuring the concentration of said intracellular component.
Claim 7
Dependent Claim
24 words
The method of claim 1 where the steps of measuring the characteristic of the intracellular component comprise measuring the activity of said intracellular component.
Claim 8
Dependent Claim
24 words
The method of claim 1 where the steps of measuring the characteristic of the intracellular component comprise measuring oxidative metabolism involving the intracellular component.
Claim 9
Dependent Claim
20 words
The method of claim 1 where the steps of measuring the characteristic comprise performing spectrophotometric evaluation of the intracellular component.
Claim 10
Dependent Claim
30 words
The method of claim 8 where the steps of performing spectrophotometric evaluation of the intracellular component comprise irradiating the tissue with a visible light wavelength radiation and detecting the radiation.
Claim 11
Dependent Claim
31 words
The method of claim 8 where the steps of performing spectrophotometric evaluation of the intracellular component comprise irradiating the tissue with a near infrared light wavelength radiation and detecting the radiation.
Claim 12
Dependent Claim
33 words
The method of claim 10 where the steps of performing spectrophotometric evaluation of said intracellular component comprise irradiating the tissue with a plurality of near infrared light wavelengths radiation and detecting the radiation.
Claim 13
Dependent Claim
20 words
The method of claim 1 where the steps of measuring the characteristic of the intracellular component comprise measuring an enzyme.
Claim 14
Dependent Claim
19 words
The method of claim 1 where the steps of measuring the characteristic of the intracellular component comprise measuring cytochrome.
Claim 15
Dependent Claim
18 words
The method of claim 1 where the step of infusing a substrate compound comprises infusing a metabolic substrate.
Claim 16
Dependent Claim
27 words
The method of claim 1 where the step of infusing a substrate compound comprises infusing a metabolic substrate for an enzyme in the oxidative metabolism redox chain.
Claim 17
Dependent Claim
27 words
The method of claim 1 where the step of infusing a substrate compound comprises infusing a compound selected from the group consisting of malate, fumarate and succinate.
Claim 18
Dependent Claim
26 words
The method of claim 1 where the step of infusing a substrate compound comprises infusing a compound known to modify the action of the intracellular component.
Claim 19
Dependent Claim
19 words
The method of claim 1 further comprising the step of a trigger compound after infusion of the substrate compound.
Claim 20
Dependent Claim
28 words
The method of claim 18 where the step of infusing a substrate compound comprises infusing glucose and where the step of infusing a trigger compound comprises infusing insulin.
Claim 21
Dependent Claim
17 words
The method of claim 18 where the step of infusing a trigger compound comprises infusing adenosine diphosphate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-03-12 | 1999-09-11 | 2000-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-03-12 | 2003-09-11 | 2004-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-03-12 | 2007-09-11 | 2008-03-12 | $7700.00 | Window Closed / Lapsed |