US5127408A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Apparatus for intravascularly measuring oxidative metabolism in body organs and tissues
Assignee: Duke University
•
Filing: 1990-09-14
•
Granted: 1992-07-07
•
Expires: 2010-09-14
Abstract
Abstract A method and apparatus for measuring oxidative metabolism in an internal organ or tissue of interest wherein a percutaneous intravascular approach is utilized to bring a light-transmitting and receiving scope into contact with the site to be assessed. The tip of the scope is adapted so that the light-transmitting optical fiber(s) and light-receiving optical fiber(s) are in divergent relationship so as to increase the photon pathlength through the tissue of interest to provide optical information from a substantial volume of tissue relative thereto.
Inventors
- 👤 William J. Parsons
- 👤 Claude A. Piantadosi
- 👤 Benjamin J. Comfort
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:54
CPC Classifications
A; A61; A61K; A61K49/00; A61B; A61B5/00; A61B5/0059; A61B5/0082; A61B5/0084; A61B5/0086
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
215 words
An apparatus for transmitting light into and receiving reflected light from internal body organs such as the heart, brain, liver and kidneys or selected body tissue with a single catheter placed into contact with said body organ or selected body tissue, comprising: an elongated tube with proximal and remote ends and having manipulator means for selectively manipulating at least the remote end thereof; at least one light-transmitting optical fiber and at least one light-receiving optical fiber positioned within said tube wherein the remote ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are divergently oriented relative to each other whereby the pathway of light transmitted by said light-transmitting optical fiber will diverge from the pathway of the portion of said light received by said light-receiving optical fiber; a light source for producing light emissions of different wavelengths and a detector means for sensing light transmitting along said light-receiving optical fiber; and connector means operatively connected to the proximal end of each of said light-transmitting optical fiber and said light-receiving optical fiber for optically connecting said light-transmitting optical fiber to said light source for producing light emissions of different wavelengths and said light-receiving optical fiber to said detector means for sensing light transmitted along said light-receiving optical fiber.
Claim 2
Independent Claim
215 words
An apparatus for transmitting light into and receiving reflected light from internal body organs such as the heart, brain, liver and kidneys or selected body tissue with a single catheter placed into contact with said body organ or selected body tissue, comprising: an elongated tube with proximal and remote ends and having manipulator means for selectively manipulating at least the remote end thereof; at least one light-transmitting optical fiber and at least one light-receiving optical fiber positioned within said tube wherein the remote ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are divergently oriented relative to each other whereby the pathway of light transmitted by said light-transmitting optical fiber will diverge from the pathway of the portion of said light received by said light-receiving optical fiber; a light source for producing light emissions of different wavelengths and a detector means for sensing light transmitting along said light-receiving optical fiber; and connector means operatively connected to the proximal end of each of said light-transmitting optical fiber and said light-receiving optical fiber for optically connecting said light-transmitting optical fiber to said light source for producing light emissions of different wavelengths and said light-receiving optical fiber to said detector means for sensing light transmitted along said light-receiving optical fiber.
Claim 3
Dependent Claim
46 words
An apparatus as defined in claim 1 wherein the remote end of said tube defines a substantially conical shape with the ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber oriented so as to be in diverging relationship.
Claim 4
Dependent Claim
21 words
An apparatus as defined in claim 1 wherein said elongated tube comprises a flexible shaft having a protective plastic sheath therearound.
Claim 5
Dependent Claim
22 words
An apparatus as defined in claim 3 wherein the outside diameter of said flexible shaft is no greater than about 3.3 mm.
Claim 6
Dependent Claim
25 words
An apparatus as defined in claim 1 wherein said manipulator means is located in a substantially medial position along the length of said elongated tube.
Claim 7
Dependent Claim
31 words
An apparatus as defined in claim 5 wherein said manipulator means allows for selectively bending the remote end of said tube up to about 120° away from the longitudinal axis thereof.
Claim 8
Dependent Claim
45 words
An apparatus as defined in claim 5 wherein the length of said tube between said manipulator means and the proximal end thereof is about 1-2 meters and the length of said tube between said manipulator means and the remote end thereof is about 100-200 centimeters.
Claim 9
Dependent Claim
27 words
An apparatus as defined in claim 1 wherein said at least one light-transmitting optical fiber comprises a plurality of optical fibers optically connected to said light source.
Claim 10
Dependent Claim
22 words
An apparatus as defined in claim 8 wherein said light emissions of different wavelengths from said light source comprise simultaneous light emissions.
Claim 11
Dependent Claim
21 words
An apparatus as defined in claim 8 wherein light emissions of different wavelengths from said light source comprise sequential light emissions.
Claim 12
Dependent Claim
16 words
An apparatus as defined in claim 1 wherein said light source provides near infrared (NIR) light.
Claim 13
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein said light source provides visible light.
Claim 14
Dependent Claim
15 words
An apparatus as defined in claim 1 wherein said light source provides near ultraviolet light.
Claim 15
Dependent Claim
14 words
An apparatus as defined in claim 1 wherein said detector means comprises a photodetector.
References Cited (Backward Citations)
US3690769A
Cited
US3948251A
Cited
US4223680A
Cited
US4281645A
Cited
US4222389A
Cited
US4513751A
Cited
US4401122A
Cited
US4803992A
Cited
US4559928A
Cited
US4641658A
Cited
US4750475A
Cited
US4696544A
Cited
US4807632A
Cited
US4832035A
Cited
US4867557A
Cited
US4907876A
Cited
US4878113A
Cited
US4922919A
Cited
US4911148A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-07-07 | 1996-01-06 | 1996-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-07-07 | 2000-01-06 | 2000-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-07-07 | 2004-01-06 | 2004-07-07 | $7700.00 | Window Closed / Lapsed |