US5161531A
Expired / Lapsed
US
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Method and apparatus for intravascularly measuring oxidative metabolism in body organs and tissues
Assignee: Duke University
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Filing: 1992-03-03
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Granted: 1992-11-10
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Expires: 2012-03-03
Abstract
Abstract A method and apparatus for measuring oxidative metabolism in an internal organ or tissue of interest wherein a percutaneous intravascular approach is utilized to bring a light-transmitting and receiving scope into contact with the site to be assessed. The tip of the scope is adapted so that the light-transmitting optical fiber(s) and light-receiving optical fiber(s) are in divergent relationship so as to increase the photon pathlength through the tissue of interest to provide optical information from a substantial volume of tissue relative thereto.
Inventors
- 👤 William J. Parsons
- 👤 Claude A. Piantadosi
- 👤 Benjamin J. Comfort
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:12
CPC Classifications
A; A61; A61K; A61K49/00; A61B; A61B5/00; A61B5/0059; A61B5/0082; A61B5/0084; A61B5/0086; A61B5/02; A61B5/145; A61B5/1455; A61B5/14551
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
230 words
A method of measuring oxygen availability and utilization in internal body organs such as the heart, brain, liver and kidneys or selected body tissue, comprising the steps of: providing a tube containing a plurality of optical fibers and comprising at least one light-transmitting optical fiber having a proximal and distal end and at least one light-receiving optical fiber having a proximal and distal end wherein said distal ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are divergently oriented relative to each other; inserting said tube through at least a portion of the length of a body conduit and into contact with an organ or tissue of interest; directing light into the proximal end of said at least one light-transmitting optical fiber so as to transmit said light therethrough and out of the distal end thereof into said organ or tissue of interest in a direction divergent from the distal end of said at least one light-receiving optical fiber; receiving reflected light which has traversed a portion of said organ or tissue of interest in the distal end of said at least one light-receiving optical fiber so as to transmit said reflected light therethrough and back to the proximal end thereof; and analyzing said reflected light to obtain measurements of oxidative metabolism and/or related data for the organ or tissue of interest.
Claim 2
Independent Claim
230 words
A method of measuring oxygen availability and utilization in internal body organs such as the heart, brain, liver and kidneys or selected body tissue, comprising the steps of: providing a tube containing a plurality of optical fibers and comprising at least one light-transmitting optical fiber having a proximal and distal end and at least one light-receiving optical fiber having a proximal and distal end wherein said distal ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are divergently oriented relative to each other; inserting said tube through at least a portion of the length of a body conduit and into contact with an organ or tissue of interest; directing light into the proximal end of said at least one light-transmitting optical fiber so as to transmit said light therethrough and out of the distal end thereof into said organ or tissue of interest in a direction divergent from the distal end of said at least one light-receiving optical fiber; receiving reflected light which has traversed a portion of said organ or tissue of interest in the distal end of said at least one light-receiving optical fiber so as to transmit said reflected light therethrough and back to the proximal end thereof; and analyzing said reflected light to obtain measurements of oxidative metabolism and/or related data for the organ or tissue of interest.
Claim 3
Dependent Claim
15 words
A method as defined in claim 1 wherein said light is near infrared (NIR) light.
Claim 4
Dependent Claim
13 words
A method as defined in claim 1 wherein said light is visible light.
Claim 5
Dependent Claim
14 words
A method as defined in claim 1 wherein said light is near ultraviolet light.
Claim 6
Dependent Claim
35 words
A method as defined in claim 1 wherein oxygen availability and utilization in the heart is measured by inserting said tube via a percutaneous, intravascular route to an endocardial point of contact within the heart.
Claim 7
Dependent Claim
38 words
A method as defined in claim 5 wherein said measurements of oxidative metabolism and related data include changes in the oxidation level of cytochrome a, a 3 copper, oxygenation of tissue hemoglobin and myoglobin, and tissue blood volume.
Claim 8
Independent Claim
234 words
A method for measuring oxygen availability and utilization in internal body organs such as the heart, brain, liver and kidneys or selected body tissue, comprising the steps of: providing a tube containing a plurality of optical fibers and comprising at least one light-transmitting optical fiber having a proximal and distal end and at least one light-receiving optical fiber having a proximal and distal end wherein said distal ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are adapted to transmit and receive light, respectively, along divergent pathways; inserting said tube through at least a portion of the length of a body conduit and into contact with an organ or tissue of interest; directing light into the proximal end of said at least one light-transmitting optical fiber so as to transmit said light therethrough and out of the distal end thereof into said organ or tissue of interest in a direction divergent from the distal end of said at least one light-receiving optical fiber; receiving reflected light which has traversed a portion of said organ or tissue of interest in the distal end of said at least one light-receiving optical fiber so as to transmit said reflected light therethrough and back to the proximal end thereof; and analyzing said reflected light to obtain measurements of oxidative metabolism and/or related data for the organ or tissue of interest.
Claim 9
Independent Claim
234 words
A method for measuring oxygen availability and utilization in internal body organs such as the heart, brain, liver and kidneys or selected body tissue, comprising the steps of: providing a tube containing a plurality of optical fibers and comprising at least one light-transmitting optical fiber having a proximal and distal end and at least one light-receiving optical fiber having a proximal and distal end wherein said distal ends of said at least one light-transmitting optical fiber and said at least one light-receiving optical fiber are adapted to transmit and receive light, respectively, along divergent pathways; inserting said tube through at least a portion of the length of a body conduit and into contact with an organ or tissue of interest; directing light into the proximal end of said at least one light-transmitting optical fiber so as to transmit said light therethrough and out of the distal end thereof into said organ or tissue of interest in a direction divergent from the distal end of said at least one light-receiving optical fiber; receiving reflected light which has traversed a portion of said organ or tissue of interest in the distal end of said at least one light-receiving optical fiber so as to transmit said reflected light therethrough and back to the proximal end thereof; and analyzing said reflected light to obtain measurements of oxidative metabolism and/or related data for the organ or tissue of interest.
Claim 10
Dependent Claim
15 words
A method as defined in claim 7 wherein said light is near infrared (NIR) light.
Claim 11
Dependent Claim
13 words
A method as defined in claim 7 wherein said light is visible light.
Claim 12
Dependent Claim
14 words
A method as defined in claim 7 wherein said light is near ultraviolet light.
Claim 13
Dependent Claim
35 words
A method as defined in claim 7 wherein oxygen availability and utilization in the heart is measured by inserting said tube via a percutaneous, intravascular route to an endocardial point of contact within the heart.
Claim 14
Dependent Claim
38 words
A method as defined in claim 11 wherein said measurements of oxidative metabolism and related data include changes in the oxidation level of cytochrome a, a 3 copper, oxygenation of tissue hemoglobin and myoglobin, and tissue blood volume.
References Cited (Backward Citations)
US4803992A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-10 | 1996-05-11 | 1996-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-10 | 2000-05-11 | 2000-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-10 | 2004-05-11 | 2004-11-10 | $7700.00 | Window Closed / Lapsed |