2'modified nucleoside and nucleotide compounds

Claim 2

A monomer having the formula: ##STR7## wherein B is a purine or pyrimidine moiety; W 1 is H, (PO 3 ) m -2 wherein m is an integer of 1-3; a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); W 2 is H, PO 3 -2 a protecting group or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); X is O, S, NR, or CR 2 wherein each R is independently H or alkyl (1-6 C); Y is a drug moiety selected from the group consisting of netropsin, anthramycin, quinoxaline antibiotics, actinomycin, and pyrrolo (1-4) benzodiazepine.

Claim 3

The monomer of claim 1 wherein X is O or S.

Claim 4

The monomer of claim 1 wherein X is NR.

Claim 5

The monomer of claim 1 wherein X is CR 2 .

Claim 6

The monomer of claim 1 wherein W 2 is a phosphonate moiety or a salt thereof.

Claim 7

The monomer of claim 1 wherein W 1 is a protecting group.

Claim 8

The monomer of claim 5 wherein said salt is a triethylammonium salt.

Claim 9

A monomer having the formula: ##STR8## wherein B is a purine or pyrimidine moiety; W 1 is H, (PO 3 ) m -2 wherein m is an integer of 1-3; a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); W 2 is H, PO 3 -2 a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); X is O, S or CR 2 wherein each R is independently H or alkyl (1-6 C); Y is selected from the group consisting of substituted or unsubstituted alkyl (2-20 C), substituted or unsubstituted alkenyl (2-20 C), substituted or unsubstituted aryl (6-20 C), wherein the substituents are selected from the group consisting of a hydroxyl, an amino, a mercaptyl, a carboxy or a keto moiety, --CH 2 COOH, --CH 2 COONH 2 , --CH 2 COOEt, --CH 2 CONHCH 2 CH 2 NH 2 and SiR" 3 wherein R" is alkyl (2-6 C).

Claim 10

A monomer having the formula: ##STR8## wherein B is a purine or pyrimidine moiety; W 1 is H, (PO 3 ) m -2 wherein m is an integer of 1-3; a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); W 2 is H, PO 3 -2 a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z wherein Z is selected from the group consisting of P(O)O -- , P(O)S, P(O)NR 2 , P(O)R, P(O)OR', CO, and CNR 2 , wherein R is H or alkyl (1-6 C) and R' is alkyl (1-6 C); X is O, S or CR 2 wherein each R is independently H or alkyl (1-6 C); Y is selected from the group consisting of substituted or unsubstituted alkyl (2-20 C), substituted or unsubstituted alkenyl (2-20 C), substituted or unsubstituted aryl (6-20 C), wherein the substituents are selected from the group consisting of a hydroxyl, an amino, a mercaptyl, a carboxy or a keto moiety, --CH 2 COOH, --CH 2 COONH 2 , --CH 2 COOEt, --CH 2 CONHCH 2 CH 2 NH 2 and SiR" 3 wherein R" is alkyl (2-6 C).