US4476301A
Expired / Lapsed
US
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Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
Assignee: Centre National de la Recherche Scientifique
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Filing: 1982-06-22
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Granted: 1984-10-09
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Expires: 2002-06-22
Abstract
Abstract The invention relates to new oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
Inventors
- 👤 Jean-Louis Imbach
- 👤 Gilles J. M. Gosselin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:00
CPC Classifications
C; C07; C07H; C07H21/00; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6515; C07F9/6518
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
55 words
Oligonucleotide comprising a chain containing in turn n identical or different nucleosidic units, n being higher than 1, preferably not higher than 10, among which at least one of the nucleosidic units is constituted by xyloadenosine, these nucleosidic units being linked by a 2'→5' bond, comprising a linking group containing at least one phosphorus atom.
Claim 2
Dependent Claim
55 words
Oligonucleotide comprising a chain containing in turn n identical or different nucleosidic units, n being higher than 1, preferably not higher than 10, among which at least one of the nucleosidic units is constituted by xyloadenosine, these nucleosidic units being linked by a 2'→5' bond, comprising a linking group containing at least one phosphorus atom.
Claim 3
Dependent Claim
38 words
Oligonucleotide according to claim 1, wherein the first nucleosidic unit and/or the last nucleosidic unit is linked to phosphate groups, preferably 1 to 3 phosphate groups, these phosphate groups being optionally separated by one to 3 methylene groups.
Claim 4
Dependent Claim
32 words
Oligonucleotide according to claims 1 or 2, wherein the 2'→5' bond comprising a linking group containing at least one phosphorous atom is a phosphodiester bond, a phosphotriester bond or an alkylphosphonate bond.
Claim 5
Dependent Claim
16 words
Oligonucleotide according to claims 1, 2 or 3, wherein all the nucleosidic units derive from adenine.
Claim 6
Dependent Claim
41 words
Oligonucleotide according to claims 1, 2 or 3, wherein all the nucleosidic units derive from adenine and the 2'→5' bond comprising a linking group containing at least one phosphorous atoms is a phosphodiester bond, a phosphotriester bond or an alkylphosphonate bond.
Claim 7
Dependent Claim
41 words
Oligonucleotide according to claims 1, 2, 3, 4 or 5, comprising one D-β-xylofurannosyl-9-adenine of formula: ##STR76## and the remaining (n-1) nucleosidic units derived from adenine are chosen from among: ribofurannosyl-adenine, arabinofurannosyl-adenine, xylofurannosyl-adenine, lyxofurannosyl-adenine, ribopyrannosyl-adenine, arabinopyrannosyl-adenine, xylopyrannosyl-adenine, lyxopyrannosyl-adenine, desoxy-3'-ribofurannosyl-adenine, desoxy-3'-arabinofurannosyl-adenine, desoxy-3'-ribopyrannosyl-adenine, desoxy-3'-arabinopyrannosyl-adenine,
Claim 8
Dependent Claim
32 words
Oligonucleotide according to claims 1, 2, 3, 4, 5 or 6, represented by the following formula: ##STR77## wherein A is adenine, its salt of quaternary ammonium, of triethyl-ammonium and its sodium salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-10-09 | 1988-04-09 | 1988-10-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-10-09 | 1992-04-09 | 1992-10-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-10-09 | 1996-04-09 | 1996-10-09 | $7700.00 | Window Closed / Lapsed |