Antiproliferative oligomers

Claim 1

A method of inhibiting proliferation of smooth muscle cells in a patient in need thereof which comprises administering to the patient an antiproliferative amount of an anionic polyamide or polyurea oligomer of formulae 1a and 1b, respectively, ##STR10## wherein X and X 3 each independently represent either a phenylene group of the formulae: ##STR11## or a biphenylene group of the formulae: ##STR12## with the proviso that in a compound of formula 1a at least one of X and X 3 must be a biphenylene moiety; X" is a group of the formulae: ##STR13## m is an integer 0 or 1, with the proviso that in a compound of formula 1b when m is 0, R is a hydrogen atom; X' can be selected from any of the phenyl or biphenyl groups of X and X 3 ; n is an integer of from 3 to 20; R represents a hydrogen atom, a C 1 -C 4 alkyl group, a phenyl group, or a phenyl group optionally substituted with 1 or 2 substituents selected from --SO 3 R 2 , --CO 2 R 2 , --PO 3 (R 2 ) 2 , or --OPO 3 R 2 and optionally substituted with from 1 to 3 substituents selected from chloro, bromo, or C 1 -C 4 alkyl; R 1 represents --SO 3 R 2 , --CO 2 R 2 , --PO 3 (R 2 ) 2 , or --OPO 3 R 2 ; R 2 represents a hydrogen atom or a pharmaceutically acceptable cation; R 3 represents --R or --X"--NH 2 , where R and X" are defined as before; R 6 represents H 2 N--X"--NH--, R 2 O--, RNH--, or R--C(═O)--NH--X"--NH--; and R 7 represents a hydrogen atom, R 2 O--C(═O)--X"--C(═O)--, R--C(═O)--, or RNH--C(═O)--X"--C(═O)--.

Claim 2

A method of inhibiting proliferation of smooth muscle cells in a patient in need thereof which comprises administering to the patient an antiproliferative amount of an anionic polyamide or polyurea oligomer of formulae 1a and 1b, respectively, ##STR10## wherein X and X 3 each independently represent either a phenylene group of the formulae: ##STR11## or a biphenylene group of the formulae: ##STR12## with the proviso that in a compound of formula 1a at least one of X and X 3 must be a biphenylene moiety; X" is a group of the formulae: ##STR13## m is an integer 0 or 1, with the proviso that in a compound of formula 1b when m is 0, R is a hydrogen atom; X' can be selected from any of the phenyl or biphenyl groups of X and X 3 ; n is an integer of from 3 to 20; R represents a hydrogen atom, a C 1 -C 4 alkyl group, a phenyl group, or a phenyl group optionally substituted with 1 or 2 substituents selected from --SO 3 R 2 , --CO 2 R 2 , --PO 3 (R 2 ) 2 , or --OPO 3 R 2 and optionally substituted with from 1 to 3 substituents selected from chloro, bromo, or C 1 -C 4 alkyl; R 1 represents --SO 3 R 2 , --CO 2 R 2 , --PO 3 (R 2 ) 2 , or --OPO 3 R 2 ; R 2 represents a hydrogen atom or a pharmaceutically acceptable cation; R 3 represents --R or --X"--NH 2 , where R and X" are defined as before; R 6 represents H 2 N--X"--NH--, R 2 O--, RNH--, or R--C(═O)--NH--X"--NH--; and R 7 represents a hydrogen atom, R 2 O--C(═O)--X"--C(═O)--, R--C(═O)--, or RNH--C(═O)--X"--C(═O)--.