Patent US5456679A successfully refreshed from Google Patents.
US5456679A
Expired / Lapsed
US
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Delivery devices with pulsatile effect
Assignee: Alza Corp
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Filing: 1994-12-07
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Granted: 1995-10-10
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Expires: 2014-12-07
Abstract
Abstract Delivery devices which include a beneficial agent and an activating mechanism in separate compartments separated by a moveable partition are designed to deliver the beneficial agent in a pulsatile manner through an orifice. The pulsatile delivery is achieved by a band of resilient material which is placed over the orifice. The resilient material is sufficiently tight to substantially seal the orifice when the pressure within the device is below a threshold level while at the same time being capable of being stretched when the internal pressure exceeds the threshold.
Inventors
- 👤 Stephen M. Balaban
- 👤 James B. Pike
- 👤 Jonathan P. Smith
- 👤 Clifton A. Baile
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0004; A61M; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M5/1452; A61M5/14526; A61M2005/14513; A61M2206/00; A61M2206/10
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
115 words
A delivery device for placement in an environment of use for the pulsatile delivery of a beneficial agent to said environment, the device comprising: an enclosure, the enclosure defining an orifice therein; activating means within said enclosure for generating a pressure within said enclosure; a beneficial agent contained within said enclosure; and resilient sealing means for sealing said orifice, said resilient means being displaced from a first position sealing said orifice to a second position opening said orifice when said pressure within said enclosure, generated by said activating means, exceeds a predetermined pressure, said resilient means returning to said first position sealing said orifice when said pressure within said enclosure fails below said threshold pressure.
Claim 2
Dependent Claim
115 words
A delivery device for placement in an environment of use for the pulsatile delivery of a beneficial agent to said environment, the device comprising: an enclosure, the enclosure defining an orifice therein; activating means within said enclosure for generating a pressure within said enclosure; a beneficial agent contained within said enclosure; and resilient sealing means for sealing said orifice, said resilient means being displaced from a first position sealing said orifice to a second position opening said orifice when said pressure within said enclosure, generated by said activating means, exceeds a predetermined pressure, said resilient means returning to said first position sealing said orifice when said pressure within said enclosure fails below said threshold pressure.
Claim 3
Dependent Claim
21 words
A delivery device in accordance with claim 1 wherein said resilient means for sealing said orifice is selected from elastomeric compounds.
Claim 4
Dependent Claim
22 words
A delivery device in accordance with claim 1 wherein said resilient means for sealing said orifice is selected from injection-moldable elastomeric compounds.
Claim 5
Dependent Claim
58 words
A delivery device in accordance with claim 1 wherein said activating means is selected from the group consisting of an osmotic engine, a thermal system, a mechanical system, a system dependent on vapor pressure of fluid, a system dependent on chemical or electrochemical reactions, an elastomeric system, a spring-loaded chamber or piston, and a system dependent on gravity.
Claim 6
Dependent Claim
51 words
A delivery device in accordance with claim 1 wherein said environment of use is an aqueous environment, at least a portion of said enclosure of said device is permeable to moisture, and said activating means includes an osmotic engine, said activating means within said portion of said enclosure permeable to moisture.
Claim 7
Dependent Claim
146 words
A delivery device in accordance with claim 5 which further comprises a partition, said partition movable from a first position to a second position within said interior, said partition dividing said interior into a first compartment and a second compartment, said beneficial agent in said first compartment and wherein said activating means includes at least one osmotically active agent in said second compartment, and in which said resilient means for sealing said orifice and said orifice are constructed such that continuous absorption of fluid from said aqueous environment causes said resilient means to be displaced from a first position sealing said orifice to a second position opening said orifice when said pressure within said enclosure, generated by said activating means, exceeds a predetermined pressure, said resilient means returning to said first position sealing said orifice when said pressure within said enclosure falls below said threshold pressure.
Claim 8
Dependent Claim
17 words
A delivery device in accordance with claim 1 which further comprises a capacitance means within said enclosure.
Claim 9
Dependent Claim
14 words
A delivery device in accordance with claim 1 which further comprises a density element.
Claim 10
Independent Claim
185 words
A device for providing delivery of a beneficial agent in a pulsatile manner to an environment of use, the device comprising: an enclosure having first and second ends and an orifice at or near said first end; a partition dividing the interior of said enclosure into a first compartment for containing a beneficial agent and a second compartment for containing an activating mechanism, said first and second compartments being adjacent to said first and second ends, respectively, said partition being capable of moving within said enclosure; a beneficial agent in said first compartment; and a band of resilient material sealing said orifice on the exterior of said enclosure and covering said orifice, said means for resiliently sealing said orifice being sufficiently tight to seal or substantially seal said orifice but capable of being displaced from a first position sealing said orifice to a second position opening said orifice when said pressure within said enclosure, generated by said activating means, exceeds a predetermined pressure, said resilient means returning to said first position sealing said orifice when said pressure within said enclosure falls below said threshold pressure.
Claim 11
Independent Claim
185 words
A device for providing delivery of a beneficial agent in a pulsatile manner to an environment of use, the device comprising: an enclosure having first and second ends and an orifice at or near said first end; a partition dividing the interior of said enclosure into a first compartment for containing a beneficial agent and a second compartment for containing an activating mechanism, said first and second compartments being adjacent to said first and second ends, respectively, said partition being capable of moving within said enclosure; a beneficial agent in said first compartment; and a band of resilient material sealing said orifice on the exterior of said enclosure and covering said orifice, said means for resiliently sealing said orifice being sufficiently tight to seal or substantially seal said orifice but capable of being displaced from a first position sealing said orifice to a second position opening said orifice when said pressure within said enclosure, generated by said activating means, exceeds a predetermined pressure, said resilient means returning to said first position sealing said orifice when said pressure within said enclosure falls below said threshold pressure.
Claim 12
Dependent Claim
20 words
A method in accordance with claim 9 wherein said means for resiliently sealing said orifice is selected from elastomeric compounds.
Claim 13
Dependent Claim
21 words
A method in accordance with claim 9 wherein said means for resiliently sealing said orifice is selected from injection-moldable elastomeric compounds.
Claim 14
Dependent Claim
57 words
A method in accordance with claim 9 wherein said activating mechanism is selected from the group consisting of an osmotic engine, a thermal system, a mechanical system, a system dependent on vapor pressure of fluid, a system dependent on chemical or electrochemical reactions, an elastomeric system, a spring-loaded chamber or piston, and a system dependent on gravity.
Claim 15
Dependent Claim
79 words
A method in accordance with claim 9 wherein said environment of use is an aqueous environment, at least a portion of said enclosure of said device adjacent to said second end is permeable to moisture, said activating mechanism is an osmotically active agent or a mixture of osmotically active agents, and said activating mechanism is activated by allowing said device to imbibe fluid from said aqueous environment through said moisture-permeable enclosure to activate said osmotically active agent or agents.
Claim 16
Dependent Claim
20 words
A method in accordance with claim 9 wherein said delivery device further comprises a capacitance means in said second compartment.
Claim 17
Dependent Claim
16 words
A method in accordance with claim 9 wherein said delivery device further comprises a density element.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1998-10-09 | 1999-04-10 | 1999-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-10-09 | 2003-04-10 | 2003-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-10-09 | 2007-04-10 | 2007-10-10 | $7700.00 | Window Closed / Lapsed |