US5167625A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multiple vesicle implantable drug delivery system
Assignee: University of Utah Research Foundation Inc
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Filing: 1990-10-09
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Granted: 1992-12-01
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Expires: 2010-10-09
Abstract
Abstract An implantable drug delivery system includes a housing having a plurality of compartments each of which includes an opening on one side thereof and a floor generally opposite the opening. Also included are a plurality of flexible drug containment sacks, each having a mouth circumscribing an opening in the sack, with the sack being disposed in a respective compartment with the mouth affixed to the opening of that compartment to seal the inside of the sack from the inside of the compartment and to enable holding a drug formulation in the sack. A plurality of covers are disposed over a respective compartment opening for preventing the release of drug formulation contained in the sacks in the compartment covered, until ruptured or removed. A plurality of gas generating elements are disposed at the floor of a respective compartment under the sack in that compartment and are responsive to initiation signals for producing gas to force the sacks and drug formulations against the covers to thereby rupture or remove the covers and force the formulations out of the housing. An electrical circuit supplies initiation signals to the gas generating means to initiate production of the gas and thus discharge of the drug formulation.
Inventors
- 👤 Stephen C. Jacobsen
- 👤 Barry K. Hanover
- 👤 Eric M. Simon
- 👤 Tomasz Petelenz
- 👤 Michael G. Mladejovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:37
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
183 words
An implantable drug delivery system comprising a housing having at least one compartment which includes an opening on one side thereof and a floor generally opposite the opening, at least one flexible drug containment each having a mouth circumscribing an opening in the sack, said sack being disposed in the compartment with the mouth affixed to the opening of the compartment to seal the inside of the sack to the inside of the compartment for holding a drug formulation in the sack, and to allow the drug solution and sack to be fully emitted from the compartment, a drug formulation disposed in the sack, a cover means disposed over the compartment opening for preventing release of drug formulation contained in the sack, gas generating means disposed at the floor of the compartment under the sack and responsive to an initiation signal for producing gas to force the sack and drug formulation against the cover means, to open the cover means, and move the sack and drug formulation out of the compartment, and means for supplying an initiation signal to the gas generating means.
Claim 2
Dependent Claim
183 words
An implantable drug delivery system comprising a housing having at least one compartment which includes an opening on one side thereof and a floor generally opposite the opening, at least one flexible drug containment each having a mouth circumscribing an opening in the sack, said sack being disposed in the compartment with the mouth affixed to the opening of the compartment to seal the inside of the sack to the inside of the compartment for holding a drug formulation in the sack, and to allow the drug solution and sack to be fully emitted from the compartment, a drug formulation disposed in the sack, a cover means disposed over the compartment opening for preventing release of drug formulation contained in the sack, gas generating means disposed at the floor of the compartment under the sack and responsive to an initiation signal for producing gas to force the sack and drug formulation against the cover means, to open the cover means, and move the sack and drug formulation out of the compartment, and means for supplying an initiation signal to the gas generating means.
Claim 3
Dependent Claim
14 words
A system as in claim 1 wherein said cover means comprises a rupturable cover.
Claim 4
Dependent Claim
125 words
A system as in claim 1 wherein said housing has a plurality of compartments, each having a polygonal top cross-section, said compartments nesting together in the housing in a compact side-by-side relationship, said system further including a plurality of flexible drug containment sacks, each disposed in a different compartment, a plurality of rupturable cover means, each disposed over a different one of the compartments, and a plurality of gas generating means, each disposed at the floor of a different one of the compartments, wherein said housing has an additional utility compartment positioned beside the plurality of compartments, and wherein said initiation signal supplying means is disposed in the utility compartment to supply initiation signals to each of the gas generating means in a predetermined manner.
Claim 5
Dependent Claim
14 words
A system as in claim 3 wherein said housing comprises an integral unitary structure.
Claim 6
Dependent Claim
26 words
A system as in claim 4 wherein said housing further includes a common bottom substrate on which the compartments and initiation signal supplying means are carried.
Claim 7
Dependent Claim
20 words
A system as in claim 5 wherein said plurality of compartments are formed in a circle about the utility compartment.
Claim 8
Dependent Claim
41 words
A system as in claim 6 wherein the openings of the compartments are located on the circumferential outer side thereof, and wherein the gas generating means are each disposed on the circumferential wall of a respective compartment opposite the respective opening.
Claim 9
Dependent Claim
37 words
A system as in claim 6 wherein the openings of the compartments are located at the top of the housing, and wherein the gas generating means are each disposed on the bottom substrate in a respective compartment.
Claim 10
Dependent Claim
31 words
A system as in claim 5 wherein said plurality of compartments are formed in two or more rows, side-by-side, with the utility compartment being disposed at one end of the rows.
Claim 11
Dependent Claim
37 words
A system as in claim 9 wherein the openings of the compartments are located at the top of the housing, and wherein the gas generating means are each disposed on the bottom substrate in a respective compartment.
Claim 12
Dependent Claim
32 words
A system as in claim 2 wherein said covers include scoring at predetermined locations to weaken the covers and allow rupture at such locations when drug formulation is forced against the covers.
Claim 13
Dependent Claim
15 words
A system as in claim 11 wherein said covers are comprised of thin metal foil.
Claim 14
Dependent Claim
15 words
A system as in claim 11 wherein said covers are comprised of a polymeric sheet.
Claim 15
Dependent Claim
15 words
A system as in claim 1 wherein said housing is constructed of injection molded polycarbonate.
Claim 16
Dependent Claim
52 words
A system as in claim 1 wherein said gas generating means comprise pyrotechnic compositions of a gas generating material responsive to heat for further heating and producing gas, heating elements disposed in contact with the compositions for heating in response to an electrical signal, and wherein said initiation signals comprise electrical signals.
Claim 17
Dependent Claim
15 words
A system as in claim 15 wherein said heating elements comprises a nickel chromium alloy.
Claim 18
Dependent Claim
21 words
A system as in claim 15 wherein said heating elements comprise compositions of palladium and rethenium disposed in contact with aluminum.
Claim 19
Dependent Claim
37 words
A system as in claim 15 wherein said initiation signal supplying means comprises a power source, and a switching circuit for operating to selectively temporarily couple the power source to the heating elements in a predetermined sequence.
Claim 20
Dependent Claim
25 words
A system as in claim 18 wherein said signal supplying means comprises conductors for carrying electrical signals from the power source to the heating elements.
Claim 21
Dependent Claim
29 words
A system as in claim 18 wherein said initiation signal supplying means further comprises means for receiving an externally transmitted signal and for initiating operation of the switching circuit.
Claim 22
Dependent Claim
75 words
A system as in claim 1 further including a second plurality of gas generating means, each disposed at the floor of a different one of the compartments, and wherein said initiation signal supplying means comprises means for supplying initiation signals to each of the first plurality of gas generating means in a predetermined sequence, and for supplying initiation signals to the second plurality of gas generating means generally simultaneously following supply to the first plurality.
References Cited (Backward Citations)
US3923060A
Cited
US4299220A
Cited
US4530664A
Cited
US4457752A
Cited
US4564363A
Cited
US4652261A
Cited
US4969873A
Cited
US4911692A
Cited
US4892037A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-12-01 | 1996-06-01 | 1996-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-12-01 | 2000-06-01 | 2000-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-12-01 | 2004-06-01 | 2004-12-01 | $7700.00 | Window Closed / Lapsed |