US5059175A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Implantable drug delivery system with piston actuation
Assignee: University of Utah Research Foundation Inc
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Filing: 1990-10-09
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Granted: 1991-10-22
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Expires: 2010-10-09
Abstract
Abstract An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
Inventors
- 👤 Barry K. Hanover
- 👤 Stephen C. Jacobsen
- 👤 Eric M. Simon
- 👤 Tomasz Petelenz
- 👤 Michael G. Mladejovsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
191 words
An implantable drug delivery system comprising an elongate housing having a plurality of elongate, generally parallel vesicles formed therein, said vesicles having an opening at one end and a bottom wall at the other end, a plurality of plungers, each disposed in a different one of the vesicles and shaped to fit and slide snugly in the corresponding vesicle, said plungers initially positioned near the bottom walls of the vesicles to allow reception and holding of drug formulation in the vesicles above the plungers, a plurality of caps, each removably positioned over a respective opening of a vesicle to prevent release of drug formulation from the vesicles, said caps being releasable to release drug formulation when formulation is forced against the caps by the upward movement of the plungers, a plurality of gas generating means, each disposed at the bottom wall of a different one of the vesicles and each being responsive to an ignition signal for igniting to generate gas and force a corresponding plunger upwardly to push drug formulation against a corresponding cap and out the vesicle, and means for selectively supplying ignition signals to said gas generating means.
Claim 2
Dependent Claim
191 words
An implantable drug delivery system comprising an elongate housing having a plurality of elongate, generally parallel vesicles formed therein, said vesicles having an opening at one end and a bottom wall at the other end, a plurality of plungers, each disposed in a different one of the vesicles and shaped to fit and slide snugly in the corresponding vesicle, said plungers initially positioned near the bottom walls of the vesicles to allow reception and holding of drug formulation in the vesicles above the plungers, a plurality of caps, each removably positioned over a respective opening of a vesicle to prevent release of drug formulation from the vesicles, said caps being releasable to release drug formulation when formulation is forced against the caps by the upward movement of the plungers, a plurality of gas generating means, each disposed at the bottom wall of a different one of the vesicles and each being responsive to an ignition signal for igniting to generate gas and force a corresponding plunger upwardly to push drug formulation against a corresponding cap and out the vesicle, and means for selectively supplying ignition signals to said gas generating means.
Claim 3
Dependent Claim
24 words
A system as in claim 1 wherein said ignition signal supplying means is disposed in the housing below the bottom walls of the vesicles.
Claim 4
Dependent Claim
24 words
A system as in claim 2 wherein one of said vesicles is positioned centrally with the other vesicles positioned circumferentially about the one vesicle.
Claim 5
Dependent Claim
24 words
A system as in claim 2 wherein said plungers are composed of material selected from the group consisting of polyurethane, synthetic rubber, and paraffin.
Claim 6
Dependent Claim
15 words
A system as in claim 2 wherein said caps are made of thin metallic foil.
Claim 7
Dependent Claim
15 words
A system as in claim 2 wherein said caps are made of a polymeric sheet.
Claim 8
Dependent Claim
14 words
A system as in claim 2 wherein said housing comprises an integral, unitary structure.
Claim 9
Dependent Claim
15 words
A system as in claim 6 wherein said housing is constructed of injection molded polycarbonate.
Claim 10
Dependent Claim
56 words
A system as in claim 2 wherein each of said gas generating means comprises a pyrotechnic composition of a gas generating material responsive to heat for further heating and producing gas, a heating element disposed in contact with the composition for heating in response to an electrical signal, and wherein said ignition signals comprise electrical signals.
Claim 11
Dependent Claim
25 words
A system as in claim 9 wherein said heating element comprises a strip of nickel chromium, and wherein said composition is disposed over the strip.
Claim 12
Dependent Claim
22 words
A system as in claim 9 wherein said heating element comprises a composition of palladium and rethenium disposed in contact with aluminum.
Claim 13
Dependent Claim
37 words
A system as in claim 9 wherein said ignition signal supplying means comprises a power source, and a switching circuit for operating to selectively temporarily couple the power source to the heating elements in a predetermined sequence.
Claim 14
Dependent Claim
25 words
A system as in claim 12 wherein said signal supplying means comprises conductors for carrying electrical signals from the power source to the heating elements.
Claim 15
Dependent Claim
28 words
A system as in claim 12 wherein said ignition signal supplying means further comprises means for receiving an externally transmitted signal for initiating operation of the switching circuit.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-10-21 | 1995-04-22 | 1995-10-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-10-21 | 1999-04-22 | 1999-10-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-10-21 | 2003-04-22 | 2003-10-22 | $7700.00 | Window Closed / Lapsed |