US5451428A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for pretreating the surface of a medical device
Assignee: HP Inc
•
Filing: 1992-03-31
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Granted: 1995-09-19
•
Expires: 2012-03-31
Abstract
Abstract A method for pretreating the surface of a medical device, and of applying a biological coating in a further step, uses the plasma polymerization technique or the plasma grafting technique. A functional monomer, i.e. a monomer with a functional group, or a mixture of a pure monomer and a substance which can provide the required functional groups under spark discharge or under the influence of charge carriers, results in a polymer coating with free functional groups which may react with the biological coating to provide optimum adhesion of the biological coating. The process is carried out in a pressure-tight chamber with an inlet for the functional monomer under low pressure and electromagnetic radiation provided by a radiation source.
Inventors
- 👤 Lothar Rupp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:06
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0076; A61L33/0088; A61L33/0005; A61L33/0011; A61L33/0029
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
108 words
Method of coating the surface of a medical device with an anti-thrombogenic coating said method comprising the steps of: (a) exposing a medical device to a chemical agent which comprises a monomer; (b) irradiating electromagnetic waves within radio frequency range into said chemical agent toward the surface of said medical device so as to form an adhesive layer of a polymer with multiple functional groups on the surface of said medical device; and (c) applying the anti-thrombogenic coating to said adhesive layer of said polymer with multiple functional groups by a direct binding process selected from the group consisting of esterification, acid amide formation, amine formation and etherification.
Claim 2
Dependent Claim
108 words
Method of coating the surface of a medical device with an anti-thrombogenic coating said method comprising the steps of: (a) exposing a medical device to a chemical agent which comprises a monomer; (b) irradiating electromagnetic waves within radio frequency range into said chemical agent toward the surface of said medical device so as to form an adhesive layer of a polymer with multiple functional groups on the surface of said medical device; and (c) applying the anti-thrombogenic coating to said adhesive layer of said polymer with multiple functional groups by a direct binding process selected from the group consisting of esterification, acid amide formation, amine formation and etherification.
Claim 3
Dependent Claim
24 words
Method according to claim 1 wherein said monomer is chemically combined with multiple functional groups and is present at least in its gaseous state.
Claim 4
Dependent Claim
44 words
Method according to claim 1 wherein said monomer is mixed width a substance which, under the influence of said electromagnetic waves, forms said multiple functional groups which in turn bind chemically to said monomer, said monomer being present at least in its gaseous state.
Claim 5
Dependent Claim
39 words
Method according to claim 3 wherein said monomer and said substance form said multiple functional groups which bind chemically to said monomer so as to form said polymer with multiple functional groups on the surface of said medical device.
Claim 6
Dependent Claim
15 words
Method according to claim 1 wherein said method is conducted in a closed pressure-tight chamber.
Claim 7
Dependent Claim
25 words
Method according to claim 5 wherein a pressure below atmospheric pressure is applied to said chamber until the pressure in said chamber is substantially vacuum.
Claim 8
Dependent Claim
23 words
Method according to claim 6 wherein the pressure in said chamber is in the range of 10 -5 bar to 10 -2 bar.
Claim 9
Dependent Claim
16 words
Method according to claim 2 wherein said monomer comprises molecules comprising at least two carbon atoms.
Claim 10
Dependent Claim
14 words
Method according to claim 8 wherein said multiple functional groups include an amino group.
Claim 11
Dependent Claim
35 words
Method according to claim 9 wherein said monomer is selected from the group consisting of allylamine, 4-amino-1-butene, any other olefin with at least one additional amino group and a combination of olefin and ammonium hydroxide.
Claim 12
Dependent Claim
14 words
Method according to claim 8 wherein said multiple functional groups include a carboxyl group.
Claim 13
Dependent Claim
22 words
Method according to claim 11, wherein said monomer is selected from the group consisting of carboxylic acids, butenoic acid and pentenoic acid.
Claim 14
Dependent Claim
14 words
Method according to claim 8 wherein said multiple functional groups include an OH group.
Claim 15
Dependent Claim
11 words
Method according to claim 13 wherein said monomer is allyl alcohol.
Claim 16
Dependent Claim
65 words
Method according to claim 1, further comprising the additional steps of: exposing said medical device to a chemically active gas; and irradiating electromagnetic waves into said chemically active gas and onto the surface of said medical device until the surface of said medical device is substantially clean of impurities; wherein said additional steps are performed prior to exposing said medical device to said chemical agent.
Claim 17
Dependent Claim
15 words
Method according to claim 1 wherein said medical device is an intravascular blood gas sensor.
Claim 18
Dependent Claim
119 words
Method of coating the surface of a medical device with an anti-thrombogenic coating, said method comprising the steps of: (a) exposing a medical device to an inert gas; (b) irradiating electromagnetic waves within radio frequency range into said inert gas toward the surface of said medical device; (c) introducing a chemical agent which comprises a monomer towards the surface of said medical device so as to form an adhesive layer of a polymer with multiple functional groups the surface of said medical device; and (d) applying the anti-thrombogenic coating to said adhesive layer of said polymer with multiple functional groups by a direct binding process selected from the group consisting of esterification, acid amide formation, amine formation and etherification.
Claim 19
Dependent Claim
119 words
Method of coating the surface of a medical device with an anti-thrombogenic coating, said method comprising the steps of: (a) exposing a medical device to an inert gas; (b) irradiating electromagnetic waves within radio frequency range into said inert gas toward the surface of said medical device; (c) introducing a chemical agent which comprises a monomer towards the surface of said medical device so as to form an adhesive layer of a polymer with multiple functional groups the surface of said medical device; and (d) applying the anti-thrombogenic coating to said adhesive layer of said polymer with multiple functional groups by a direct binding process selected from the group consisting of esterification, acid amide formation, amine formation and etherification.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-09-18 | 1999-03-20 | 1999-09-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-09-18 | 2003-03-20 | 2003-09-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-09-18 | 2007-03-20 | 2007-09-19 | $7700.00 | Window Closed / Lapsed |