US4897433A
Expired / Lapsed
US
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Process for producing an anti-thrombogenic material by graft polymerization
Assignee: Japan Atomic Energy Agency
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Filing: 1987-12-03
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Granted: 1990-01-30
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Expires: 2007-12-03
Abstract
Abstract A process for producing a medical material having high anti-thrombogenicity that is suitable for use in catheters and other medical devices in contact with blood flowing in circulatory organs and other tissues is disclosed. According to this process, an acrylamide or methacrylamide derivative having a tertiary amino group, or an unsaturated monomer having a hydrophihlic group and the ability to promote copolymerization, or a mixture thereof is graft polymerized onto a polyurethane elastomeric or polyolefinic high-molecular weight substrate with an ionizing radiation.
Inventors
- 👤 Takanobu Sugo
- 👤 Jiro Okamoto
- 👤 Seiryo Tasaki
- 👤 Tadayuki Onishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:39
CPC Classifications
C; C08; C08F; C08F255/00; C08F255/02; A; A61; A61L; A61L33/00; A61L33/0076; A61L33/0088; C08F283/00; C08F283/006; C08F291/00; C08F291/18; C08F291/185; C08J; C08J7/00; C08J7/12; C08J7/16; C08J7/18; Y; Y10; Y10T; Y10T428/00; Y10T428/13; Y10T428/1352
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
106 words
A process for producing an anti-thrombogenic material in which an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrlamide, and a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, and acrylamide and N-vinylpyrrolidone are graft polymerized with an ionizing radiation onto a high-molecular weight substrate comprising a polyurethane elastomeric polymer or a polyolefinic polymer.
Claim 2
Dependent Claim
106 words
A process for producing an anti-thrombogenic material in which an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrlamide, and a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, and acrylamide and N-vinylpyrrolidone are graft polymerized with an ionizing radiation onto a high-molecular weight substrate comprising a polyurethane elastomeric polymer or a polyolefinic polymer.
Claim 3
Dependent Claim
62 words
A process for producing an anti-thrombogenic material which comprises generating active sites on a polyurethane elastomeric or polyolefinic high-molecular weight substrate by treatment with an ionizing radiation, and immersing the treated substrate in a solution of an acrylamide or methacrylamide having a tertiary amino group selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethylaminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrylamide, so as to effect graft polymerization.
Claim 4
Dependent Claim
62 words
A process for producing an anti-thrombogenic material which comprises generating active sites on a polyurethane elastomeric or polyolefinic high-molecular weight substrate by treatment with an ionizing radiation, and immersing the treated substrate in a solution of an acrylamide or methacrylamide having a tertiary amino group selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethylaminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N-diethylaminopropylmethacrylamide, so as to effect graft polymerization.
Claim 5
Dependent Claim
107 words
A process for producing an anti-thrombogenic material which comprises immersing a polyurethane elastomeric high-molecular weight substrate in a mixed solution of an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N diethylaminopropylmethacrylamide, and a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, an acrylamide and N-vinylpyrrolidone, and applying an ionizing radiation to effect co-graft polymerization.
Claim 6
Dependent Claim
107 words
A process for producing an anti-thrombogenic material which comprises immersing a polyurethane elastomeric high-molecular weight substrate in a mixed solution of an acrylamide or methacrylamide selected from the group consisting of N,N-dimethylaminopropylacrylamide, N,N-diethyl aminopropylacrylamide, N,N-dimethylaminopropylmethacrylamide and N,N diethylaminopropylmethacrylamide, and a copolymerization promotor of at least one unsaturated monomer selected from the group consisting of an acrylate or methacrylate having an oligooxyethylene group whose degree of polymerization is 2-10, an acrylate or methacrylate having a hydrocarbon group with no more than 3 carbon atoms into which an alcoholic or glycolic hydroxyl group has been introduced, an acrylamide and N-vinylpyrrolidone, and applying an ionizing radiation to effect co-graft polymerization.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-01-29 | 1993-07-31 | 1994-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-29 | 1997-07-31 | 1998-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-29 | 2001-07-31 | 2002-01-30 | $7700.00 | Window Closed / Lapsed |