Patent US934672A successfully refreshed from Google Patents.
Patent US5437633A successfully refreshed from Google Patents.
US5437633A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Selective aortic arch perfusion
Assignee: University of North Carolina at Chapel Hill
•
Filing: 1994-03-30
•
Granted: 1995-08-01
•
Expires: 2014-03-30
Abstract
Abstract A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such-as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored. In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.
Inventors
- 👤 James E. Manning
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:21
CPC Classifications
A; A61; A61M; A61M31/00; A61M2202/00; A61M2202/04; A61M2210/00; A61M2210/12; A61M2210/125
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
91 words
A method of treating a subject in cardiac arrest, comprising: blocking the descending aorta of said subject; and then perfusing the aortic arch of said subject with an oxygen-carrying protective solution in an amount effective to deliver oxygen to the heart of said subject, and concurrently administering said subject an alpha adrenergic receptor agonist in an amount effective to enhance coronary perfusion with said protective solution; and wherein said perfusing step is carried out by infusing an initial bolus of protective solution, followed by a less rapid infusion of protective solution.
Claim 2
Independent Claim
91 words
A method of treating a subject in cardiac arrest, comprising: blocking the descending aorta of said subject; and then perfusing the aortic arch of said subject with an oxygen-carrying protective solution in an amount effective to deliver oxygen to the heart of said subject, and concurrently administering said subject an alpha adrenergic receptor agonist in an amount effective to enhance coronary perfusion with said protective solution; and wherein said perfusing step is carried out by infusing an initial bolus of protective solution, followed by a less rapid infusion of protective solution.
Claim 3
Dependent Claim
16 words
A method according to claim 1, wherein said administering step is carried out by parenteral injection.
Claim 4
Dependent Claim
28 words
A method according to claim 1, wherein said administering step is carried out by including said alpha adrenergic receptor agonist in said protective solution during said prefusing step.
Claim 5
Dependent Claim
13 words
A method according to claim 1, wherein said perfluorochemical solution comprises an emulsion.
Claim 6
Dependent Claim
24 words
A method according to claim 1, wherein said alpha adrenergic receptor agonist is selected from the group consisting of epinephrine, norepinephrine, methoxamine, and phenylephrine.
Claim 7
Dependent Claim
22 words
A method according to claim 1, wherein said perfusing step is followed by the step of: restoring spontaneous circulation in said subject.
Claim 8
Dependent Claim
16 words
A method according to claim 6, wherein said restoring step is carried out by electric shock.
Claim 9
Dependent Claim
31 words
A method according to claim 1, wherein said perfusing step is carried out by perfusing the aortic arch of said subject with from 250 to 2000 milliliters of said protective solution.
Claim 10
Dependent Claim
22 words
A method according to claim 1, wherein said perfusing step is carried out for a time of not more than five minutes.
Claim 11
Dependent Claim
36 words
A method according to claim 1, wherein said blocking step is carried out with a balloon catheter, and wherein said perfusing step is carried out by administering said protective solution through the lumen of said catheter.
Claim 12
Independent Claim
92 words
A method of treating a subject in cardiac arrest, comprising: blocking the descending aorta of said subject; and then perfusing the aortic arch of said subject with a perfluorochemical oxygen-carrying protective solution in an amount effective to deliver oxygen to the heart of said subject, and concurrently administering said subject an alpha adrenergic receptor agonist in an amount effective to enhance coronary perfusion with said protective solution; and wherein said perfusing step is carried out by infusing an initial bolus of protective solution, followed by a less rapid infusion of protective solution.
Claim 13
Independent Claim
92 words
A method of treating a subject in cardiac arrest, comprising: blocking the descending aorta of said subject; and then perfusing the aortic arch of said subject with a perfluorochemical oxygen-carrying protective solution in an amount effective to deliver oxygen to the heart of said subject, and concurrently administering said subject an alpha adrenergic receptor agonist in an amount effective to enhance coronary perfusion with said protective solution; and wherein said perfusing step is carried out by infusing an initial bolus of protective solution, followed by a less rapid infusion of protective solution.
Claim 14
Dependent Claim
16 words
A method according to claim 11, wherein said administering step is carried out by parenteral injection.
Claim 15
Dependent Claim
28 words
A method according to claim 11, wherein said administering step is carried out by including said alpha adrenergic receptor agonist in said protective solution during said prefusing step.
Claim 16
Dependent Claim
13 words
A method according to claim 11, wherein said perfluorochemical solution comprises an emulsion.
Claim 17
Dependent Claim
24 words
A method according to claim 11, wherein said alpha adrenergic receptor agonist is selected from the group consisting of epinephrine, norepinephrine, methoxamine, and phenylephrine.
Claim 18
Dependent Claim
22 words
A method according to claim 11, wherein said perfusing step is followed by the step of: restoring spontaneous circulation in said subject.
Claim 19
Dependent Claim
16 words
A method according to claim 16, wherein said restoring step is carried out by electric shock.
Claim 20
Dependent Claim
31 words
A method according to claim 11, wherein said perfusing step is carried out by perfusing the aortic arch of said subject with from 250 to 2000 milliliters of said protective solution.
Claim 21
Dependent Claim
22 words
A method according to claim 11, wherein said perfusing step is carried out for a time of not more than five minutes.
Claim 22
Dependent Claim
36 words
A method according to claim 11, wherein said blocking step is carried out with a balloon catheter, and wherein said perfusing step is carried out by administering said protective solution through the lumen of said catheter.
References Cited (Backward Citations)
US3962439A
Cited
US4686085A
Cited
US5085630A
Cited
SU1076119A1
Cited
US5334142A
Cited
US5216032A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-07-31 | 1999-01-30 | 1999-08-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-07-31 | 2003-01-30 | 2003-08-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-07-31 | 2007-01-30 | 2007-08-01 | $7700.00 | Window Closed / Lapsed |