US4686085A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
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Filing: 1984-02-23
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Granted: 1987-08-11
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Expires: 2004-02-23
Abstract
Abstract A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:18
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K9/0029; A61M; A61M3/00; A61M3/02; A61M3/0204; A61M3/0212; A61M25/00; A61M25/01; A61M25/02; A61M2025/028; A61M2202/00; A61M2202/04; A61M2202/0464; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653; A61M2210/00; A61M2210/06; A61M2210/0693
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
126 words
An oxygenation apparatus for use in treating hypoxic ischemic neurologic tissue comprising: (a) reservoir means for containing synthetic organic oxygenatable fluid which is physiologically acceptable to neurologic tissue; (b) oxygenator means connected in fluid communication with said fluid in said reservoir means for oxygenating said fluid; (c) first flow control means for establishing a circulation of said fluid between said oxygenator means and said reservoir means at a first preselected rate; (d) injection means connected in fluid communication with said fluid in said reservoir means for injecting said fluid into the extravascular cerebrospinal pathway; (e) second flow control means for establishing flow of said fluid through said injection means at a second preselected rate; and (f) withdrawal means for withdrawing of fluid from said cerebrospinal pathway.
Claim 2
Dependent Claim
126 words
An oxygenation apparatus for use in treating hypoxic ischemic neurologic tissue comprising: (a) reservoir means for containing synthetic organic oxygenatable fluid which is physiologically acceptable to neurologic tissue; (b) oxygenator means connected in fluid communication with said fluid in said reservoir means for oxygenating said fluid; (c) first flow control means for establishing a circulation of said fluid between said oxygenator means and said reservoir means at a first preselected rate; (d) injection means connected in fluid communication with said fluid in said reservoir means for injecting said fluid into the extravascular cerebrospinal pathway; (e) second flow control means for establishing flow of said fluid through said injection means at a second preselected rate; and (f) withdrawal means for withdrawing of fluid from said cerebrospinal pathway.
Claim 3
Dependent Claim
38 words
The apparatus of claim 2 whrein said first flow control means establishes said first preselected rate to achieve a pO 2 level of at least about 60% of the saturated maximum pO 2 value of said oxygenatable fluid.
Claim 4
Dependent Claim
35 words
The apparatus of claim 2 whrein said first flow control means establishes said first preselected rate to achieve an oxygenation of said oxygenatable fluid of at least 80% of its saturated maximum pO 2 value.
Claim 5
Dependent Claim
36 words
The apparatus of claim 1 wherein said first flow control means acts in combination with said oxygenator means to provide a fluid in said reservoir means which is oxygenated to a pO 2 value above 600.
Claim 6
Dependent Claim
28 words
The apparatus of claim 1 wherein said oxygenatable fluid comprises perfluorobutyltetrahydrofuran exhibiting a range of efficient oxygen exchange which is substantially linear between about 760 and 200 TORR.
Claim 7
Dependent Claim
18 words
The apparatus of claim 1 further comprising heat exchanger means 104 for adjusting the temperature of said fluid.
Claim 8
Dependent Claim
26 words
The apparatus of claim 6 further comprising third flow control means 105 for establishing a separate circulation between said reservoir means and said heat exchanger means.
Claim 9
Dependent Claim
17 words
The apparatus of claim 7 wherein said third flow control means establishes a third preselected flow rate.
Claim 10
Dependent Claim
21 words
The apparatus of claim 1 further comprising filtration means for filtering said fluid prior to its injection by said injection means.
Claim 11
Dependent Claim
13 words
The apparatus of claim 9 wherein said filtration means comprises a bacterial filter.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-10 | 1991-02-09 | 1991-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-10 | 1995-02-09 | 1995-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-10 | 1999-02-09 | 1999-08-11 | $7700.00 | Window Closed / Lapsed |