US5403893A — Interpenetrating-polymer network phase-transition…

Claim 1

Independent Claim 45 words

A composition of matter, comprising: a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel capable of undergoing a reversible, continuous or discontinuous phase transition in response to a change in a specific stimulus applied to the gel.

Claim 2

Dependent Claim 45 words

A composition of matter, comprising: a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel capable of undergoing a reversible, continuous or discontinuous phase transition in response to a change in a specific stimulus applied to the gel.

Claim 3

Dependent Claim 30 words

The composition of claim 1, wherein said phase-transition is initiated by a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

Claim 4

Dependent Claim 22 words

The composition of claim 1, wherein said gel undergoes a discontinuous phase-transition collapse in response to the change in the specific stimulus.

Claim 5

Dependent Claim 75 words

A composition of matter, comprising: an interpenetrating polymer network gel including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition in response to a change in a stimulus applied to the gel.

Claim 6

Dependent Claim 75 words

A composition of matter, comprising: an interpenetrating polymer network gel including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition in response to a change in a stimulus applied to the gel.

Claim 7

Dependent Claim 31 words

The composition of claim 4, wherein the at least one type of interaction is selected from the group consisting of van der Waals forces, hydrophobic interactions, hydrogen bonding, and ionic interactions.

Claim 8

Dependent Claim 43 words

The composition of claim 5, wherein the hydrogen bonding between said at least first and second polymers allows said polymers to form a polycomplex in which said polymers are aligned, polycomplex formation sufficient to induce said gel to undergo a discontinuous phase transition.

Claim 9

Dependent Claim 44 words

The composition of claim 4, wherein said change in stimulus is a change in temperature from a higher temperature to a lower temperature sufficient to cause the gel to undergo a phase-transition collapse in response to the change in temperature applied to the gel.

Claim 10

Dependent Claim 80 words

A gel network capable of undergoing a continuous or discontinuous phase-transition in response to a change in a stimulus, the gel comprising: an interpenetrating network of at least a first polymer and at least a second polymer, said polymers interpenetrating in a manner that results in an attractive interaction between the polymers of said network; wherein said attractive interaction is sufficient to cause the gel network to undergo phase-transition in response to a change in stimulus applied to the gel.

Claim 11

Dependent Claim 80 words

A gel network capable of undergoing a continuous or discontinuous phase-transition in response to a change in a stimulus, the gel comprising: an interpenetrating network of at least a first polymer and at least a second polymer, said polymers interpenetrating in a manner that results in an attractive interaction between the polymers of said network; wherein said attractive interaction is sufficient to cause the gel network to undergo phase-transition in response to a change in stimulus applied to the gel.

Claim 12

Dependent Claim 24 words

The gel of claim 8, wherein said interpenetrating polymers are arranged to result in hydrogen bonding between said at least first and second polymers.

Claim 13

Dependent Claim 13 words

The gel of claim 9, wherein at least said first polymer is ionized.

Claim 14

Dependent Claim 47 words

The gel of claim 10, wherein ionization of at least one of said first or second polymers is directly related to the phase transition, such that a larger degree of ionization effects a discontinuous phase transition, and a smaller degree of ionization effects a continuous phase transition.

Claim 15

Dependent Claim 20 words

The gel of claim 11, wherein said at least first polymer is polyacrylic acid and said second polymer is polyacrylamide.

Claim 16

Dependent Claim 28 words

The gel of claim 12, wherein said first polymer is not ionized and said gel undergoes a continuous phase transition collapse in response to a decrease in temperature.

Claim 17

Dependent Claim 33 words

The gel of claim 12, wherein said first polymer is ionized to greater than about 3 percent and said gel undergoes a discontinuous phase transition collapse in response to a decrease in temperature.

Claim 18

Dependent Claim 40 words

The gel of claim 8, further comprising a chemical incorporated into the gel network, said chemical capable of being released from the gel network upon a phase-transition collapse in response to a change in stimulus applied to the gel network.

Claim 19

Independent Claim 112 words

A method for incorporating a material into a gel, comprising the steps of: providing an interpenetrating polymer gel network including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition expansion in response to a change in a stimulus applied to the gel; contacting the gel network with the material; changing the specific stimulus such that the gel network undergoes phase-transition expansion, thereby incorporating the material into the gel network.

Claim 20

Independent Claim 112 words

A method for incorporating a material into a gel, comprising the steps of: providing an interpenetrating polymer gel network including at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition expansion in response to a change in a stimulus applied to the gel; contacting the gel network with the material; changing the specific stimulus such that the gel network undergoes phase-transition expansion, thereby incorporating the material into the gel network.

Claim 21

Independent Claim 108 words

A method for releasing a material from a gel, comprising the steps of: providing an interpenetrating polymer gel network including the material and at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition collapse in response to a change in a stimulus applied to the gel; changing the specific stimulus such that the gel network undergoes a phase-transition collapse, thereby releasing the material from the gel.

Claim 22

Independent Claim 108 words

A method for releasing a material from a gel, comprising the steps of: providing an interpenetrating polymer gel network including the material and at least a first polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase-transition collapse in response to a change in a stimulus applied to the gel; changing the specific stimulus such that the gel network undergoes a phase-transition collapse, thereby releasing the material from the gel.

Claim 23

Dependent Claim 74 words

In a polymer, wherein the improvement comprises: at least a first polymer and at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a continuous or discontinuous phase-transition in response to a change in a stimulus applied to the gel.

Claim 24

Dependent Claim 74 words

In a polymer, wherein the improvement comprises: at least a first polymer and at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a continuous or discontinuous phase-transition in response to a change in a stimulus applied to the gel.

Claim 25

Dependent Claim 30 words

The polymer of claim 18, wherein said phase-transition is initiated by a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

Claim 26

Dependent Claim 59 words

The polymer of claim 18, wherein the interaction is hydrogen bonding between said at least first and second polymers, said hydrogen bonding allowing said polymers to form a polycomplex in which said polymers are aligned, polycomplex formation sufficient to induce said gel to undergo a discontinuous phase transition in response to a change in stimulus applied to the gel.

Claim 27

Dependent Claim 15 words

The polymer of claim 20, wherein said change in stimulus is a change in temperature.

Claim 28

Dependent Claim 20 words

The polymer of claim 20, wherein said at least first polymer is polyacrylic acid and said second polymer is polyacrylamide.

Claim 29

Independent Claim 78 words

A method of releasing a material in response to a change in stimulus comprising the steps of: introducing the material into a medium; coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition in response to the change in stimulus applied to the gel; and changing the stimulus such that the gel coating expands and the material is released.

Claim 30

Independent Claim 78 words

A method of releasing a material in response to a change in stimulus comprising the steps of: introducing the material into a medium; coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition in response to the change in stimulus applied to the gel; and changing the stimulus such that the gel coating expands and the material is released.

Claim 31

Dependent Claim 15 words

The method of claim 23, wherein the step of changing the stimulus comprises increasing pH.

Claim 32

Dependent Claim 15 words

The method of claim 23, wherein the step of introducing the material comprises introducing insulin.

Claim 33

Dependent Claim 20 words

The method of claim 24, wherein the step of changing the stimulus comprises exposing the coated medium to an intestine.

Claim 34

Independent Claim 57 words

A method of absorbing a compound comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound; and contacting the gel with the compound such that the gel expands and absorbs the compound.

Claim 35

Independent Claim 57 words

A method of absorbing a compound comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound; and contacting the gel with the compound such that the gel expands and absorbs the compound.

Claim 36

Dependent Claim 19 words

The method of claim 27, wherein the step of contacting the gel with the compound comprises contacting with cholesterol.

Claim 37

Independent Claim 68 words

A method of separating a compound from a liquid medium comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound; contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.

Claim 38

Independent Claim 68 words

A method of separating a compound from a liquid medium comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, the gel being capable of undergoing a reversible phase transition when contacted with the compound; contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.

Claim 39

Dependent Claim 30 words

The composition of claim 4, wherein said change in stimulus is a change in at least one of temperature, pH, solvent concentration, light irradiation, electric field strength and ion concentration.

Claim 40

Dependent Claim 25 words

The composition of claim 4, wherein said interpenetrating polymer network gel undergoes a discontinuous phase-transition collapse in response to the change in the specific stimulus.

Claim 41

Dependent Claim 22 words

The gel of claim 9, wherein said hydrogen bonding interaction between the first and second polymers increases hydrophobicity of said polymer network.

Claim 42

Independent Claim 111 words

A method of releasing a material in response to a change in stimulus comprising the steps of: introducing the material into a medium; coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition in response to the change in stimulus applied to the gel; and changing the stimulus such that the gel coating expands and the material is released.

Claim 43

Independent Claim 111 words

A method of releasing a material in response to a change in stimulus comprising the steps of: introducing the material into a medium; coating the medium with a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition in response to the change in stimulus applied to the gel; and changing the stimulus such that the gel coating expands and the material is released.

Claim 44

Dependent Claim 15 words

The method of claim 33, wherein the step of introducing the material comprises increasing pH.

Claim 45

Dependent Claim 15 words

The method of claim 33, wherein the step of introducing the material comprises introducing insulin.

Claim 46

Dependent Claim 20 words

The method of claim 34, wherein the step of changing the stimulus comprises exposing the coated medium to an intestine.

Claim 47

Independent Claim 89 words

A method of absorbing a compound comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase transition when contacted with the compound; and contacting the gel with the compound such that the gel expands and absorbs the compound.

Claim 48

Independent Claim 89 words

A method of absorbing a compound comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction sufficient to cause the gel to undergo a phase transition when contacted with the compound; and contacting the gel with the compound such that the gel expands and absorbs the compound.

Claim 49

Dependent Claim 19 words

The method of claim 36, wherein the step of contacting the gel with the compound comprises contacting with cholesterol.

Claim 50

Independent Claim 101 words

A method of separating a compound from a liquid medium comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition when contacted with the compound; contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.

Claim 51

Independent Claim 101 words

A method of separating a compound from a liquid medium comprising the steps of: providing a polymer gel that includes at least one polymer interpenetrating at least a second polymer, said polymers arranged with respect to each other so that at least one type of interaction develops between at least the first and second polymers, the at least one type of interaction being sufficient to cause the gel to undergo a phase transition when contacted with the compound; contacting the gel with a liquid solution containing the compound such that the gel contracts and the compound is retained within the gel.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1998-04-03	1998-10-03	1999-04-04	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	2002-04-03	2002-10-03	2003-04-04	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2006-04-03	2006-10-03	2007-04-04	$7700.00	Window Closed / Lapsed

Interpenetrating-polymer network phase-transition gels

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