EP0347145A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Heterogeneous interpenetrating polymer networks for the controlled release of drugs
Assignee: University of Utah Research Foundation Inc
•
Filing: 1989-06-12
•
Granted: —
•
Expires: 2009-06-12
Abstract
Abstract A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N′-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains" can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.
Inventors
- 👤 You Han Bae
- 👤 Teruo Okano
- 👤 Sung Wan Kim
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-03 13:15
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2031; A61K9/2027
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
58 words
A drug-containing three-dimensional interpenetrating polymer network (IPN), comprising: (a) a matrix of a first polymeric material; (b) a second polymeric material dispersed throughout said matrix, wherein one of said polymeric materials is hydrophilic and the other of said materials is hydrophobic; and (c) a drug either dissolved or or dispersed in one or both of said polymeric materials.
Claim 2
Dependent Claim
58 words
A drug-containing three-dimensional interpenetrating polymer network (IPN), comprising: (a) a matrix of a first polymeric material; (b) a second polymeric material dispersed throughout said matrix, wherein one of said polymeric materials is hydrophilic and the other of said materials is hydrophobic; and (c) a drug either dissolved or or dispersed in one or both of said polymeric materials.
Claim 3
Dependent Claim
17 words
The IPN of claim 1, wherein said first material is hydrophilic and said second material is hydrophobic.
Claim 4
Dependent Claim
17 words
The IPN of claim 1, wherein said first material is hydrophobic and said second material is hydrophilic.
Claim 5
Dependent Claim
29 words
The IPN of claim 1, wherein the diffusivity D₁ of the drug in said first material is different than the diffusivity D₂ of the drug in said second material.
Claim 6
Dependent Claim
29 words
The IPN of claim 1, wherein the solubility S₁ of the drug in said first material is different than the solubility S₂ of the drug in said second material.
Claim 7
Dependent Claim
27 words
The IPN of claim 1, wherein the weight ratio of said first material to said second material is in the range of about 9:1 to about 1:4.
Claim 8
Dependent Claim
19 words
The IPN of claim 1, wherein said weight ratio is in the range of about 6:4 to about 4:6.
Claim 9
Dependent Claim
18 words
The IPN of claim 1, wherein only one of said first and said second materials contain a drug.
Claim 10
Dependent Claim
15 words
The IPN of claim 1, wherein both of said first and second materials contain drug.
Claim 11
Dependent Claim
21 words
The IPN of claim 9, wherein said first material contains a first drug and said second material contains a second drug.
Claim 12
Dependent Claim
30 words
The IPN of claim 1, wherein the hydrophilic material is polyethylene oxide crosslinked with a triisocyanate and the hydrophobic material is polystyrene or poly(butyl methacrylate) crosslinked with ethylene glycol dimethacrylate.
Claim 13
Dependent Claim
21 words
The IPN of claim 1, wherein the hydrophilic material is poly(N,N′-dimethyl acrylamide co-styrene) and the hydrophobic material is polytetramethylene ether glycol.
Claim 14
Independent Claim
68 words
A method for making a drug-containing IPN, comprising: polymerizing a first component to give a matrix of a first polymeric material; polymerizing a second component to give an IPN having a second polymeric material within said matrix, wherein one of said first and said second materials is hydrophilic and the other of said materials is hydrophobic; and incorporating drug in the IPN by immersion in a drug solution.
Claim 15
Independent Claim
68 words
A method for making a drug-containing IPN, comprising: polymerizing a first component to give a matrix of a first polymeric material; polymerizing a second component to give an IPN having a second polymeric material within said matrix, wherein one of said first and said second materials is hydrophilic and the other of said materials is hydrophobic; and incorporating drug in the IPN by immersion in a drug solution.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.